HLA-A30

HLA-A30 (A30) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α30 subset of HLA-A α-chains. For A30, the alpha "A" chain are encoded by the HLA-A*30 allele group and the β-chain are encoded by B2M locus.[1] A30 and A*30 are almost synonymous in meaning. A30 is a split antigen of the broad antigen serotype A19. A30 is a sister serotype of A29, A31, A32, A33, and A74.

HLA-A30
(MHC Class I, A cell surface antigen)
HLA-A30
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-A*30--, β2-microglobulin
Older namesA19
Subtypes
Subtype
allele
Available structures
A30.3 *3001
A30.2 *3002
{{{cNick3}}} *30{{{cAllele3}}}
{{{cNick4}}} *30{{{cAllele4}}}
Rare alleles
Subtype
allele
Available structures
A30.4 *3004
{{{rnick2}}} *30{{{rallele2}}}
{{{rnick3}}} *30{{{rallele3}}}
Alleles link-out to IMGT/HLA database at EBI


Serotype

A30 recognition of some HLA A*30 gene products[2]
A*30 A30 A19A31 Sample
allele % % % size (N)
*300189133517
*300293122124
*30049400  85



Alleles

HLA A*3001 frequencies
Study populationFreq.
 (in %)[3]
India West Coast Parsis16.0
Mali Bandiagara14.1
Zambia Lusaka14.0
South African Natal Zulu9.5
Jordan Amman9.3
Pakistan Kalash9.2
Zimbabwe Harare Shona9.1
China Beijing9.0
Kenya8.4
Sudanese6.8
Kenya Luo6.4
India Khandesh Pawra6.0
Pakistan Pathan5.6
Cameroon Yaounde5.5
USA African America5.0
Kenya Nandi4.8
Tunisia4.1
Cameroon Beti4.0
China Inner Mongolia3.9
Cameroon Sawa3.8
China North Han3.8
Guinea Bissau3.8
Senegal Niokholo Mandenka3.8
South Korea (3)3.5
India North Delhi3.3
Cameroon Bamileke3.2
Pakistan Baloch3.2
Uganda Kampala3.1
Israel Arab Druse3.0
China Qinghai Hui2.7
USA Hispanic2.6
Brazil2.5
France South East2.3
Iran Baloch2.2
Saudi Arabia Guraiat and …2.1
USA North American Native…2.1
Portugal Centre2.0
Romanian2.0
Czech Republic1.9
Taiwan Hakka1.8
USA Asian1.8
Brazil Terena1.7
Georgia Tbilisi Kurds1.7
USA Caucasians (3)1.7
China South Han1.6
Morocco Nador Metalsa Cla…1.4
Croatia1.3
Macedonia (4)1.2
Mexico Mestizos1.2
India Andhra Pradesh Goll…1.1
Ireland Northern1.1
Mexico Chihuahua State Ta…1.1
Mongolia Buriat1.1
Pakistan Brahui1.1
Portugal North1.1
Thailand1.1
Allele frequencies presented, only
HLA A*3002 frequencies
Study populationFreq.
 (in %)[3]
Zambia Lusaka23.3
Zimbabwe Harare Shona14.7
Senegal Niokholo Mandenka12.4
Cameroon Beti9.5
Morocco 'Berber' Nador Me…8.9
South African Natal Zulu8.5
Cameroon Sawa7.7
Cameroon Bamileke7.1
Cameroon Yaounde6.0
Kenya Luo5.9
USA African Americans (3)5.8
Tunisia5.6
Cameroon Pygmy Baka5.0
Mexico Guadalajara Mestiz…4.9
Oman4.2
Pakistan Baloch4.0
Uganda Kampala4.0
Kenya Nandi3.7
Mali Bandiagara3.4
Pakistan Brahui3.4
USA Hispanic3.4
Guinea Bissau3.1
USA South Texas Hispanics3.0
Iran Baloch2.8
Sudanese2.8
Brazil2.5
Portugal Centre2.0
Saudi Arabia Guraiat and …1.9
USA North American Native…1.9
Georgia Tbilisi Kurds1.7
Belgium1.6
France South East1.2
Ireland Northern1.2
Macedonia1.2
Pakistan Burusho1.1
USA Caucasian Bethesda1.1
Allele frequencies presented, only

Disease association

A*3002 alters Type 1 diabetes risk[4]

References

  1. Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. Allele Query Form IMGT/HLA - European Bioinformatics Institute
  3. Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
  4. Noble J, Valdes A, Bugawan T, Apple R, Thomson G, Erlich H (2002). "The HLA class I A locus affects susceptibility to type 1 diabetes". Hum Immunol. 63 (8): 657–64. doi:10.1016/S0198-8859(02)00421-4. PMC 4049513. PMID 12121673.
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