HLA-A80

HLA-A80 (A80) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α80 subset of HLA-A α-chains. For A80, the alpha "A" chain are encoded by the HLA-A*80 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*8001. A80 and A*80 are almost synonymous in meaning.

Further information: History and naming of human leukocyte antigens
HLA-A80
(MHC Class I, A cell surface antigen)
HLA-A80
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-A*8001, β2-microglobulin
Older namesAX"BG"
Subtypes
Subtype
allele
Available structures
A*80 *8001
{{{cNick2}}} *80{{{cAllele2}}}
{{{cNick3}}} *80{{{cAllele3}}}
{{{cNick4}}} *80{{{cAllele4}}}
Alleles link-out to IMGT/HLA database at EBI

A80 is more common in West Central Africa. A80 is the least common HLA-A allele group.

Serotype
A80 recognition of some HLA A*80 gene products[2]
A*80 A80 A10 Sample
allele % % size (N)
*80013610505

A80 HLA-A80 typing is poor. Most typing is done with SSP-PCR. Most of 8001 are detected with "Blank" serotype..

Distribution
HLA A*8001 frequencies
Study populationFreq.
 (in %)[3]
Senegal Niokholo Mandenka3.8
Zambia Lusaka2.3
Cameroon Bamileke1.9
Mali Bandiagara1.5
South Africa Tswana1.2
Spain Menorca1.1
Cameroon Bakola Pygmy1.0
Burkina Faso Fulani1.0
Trinidad Africans1.0
Tunisia1.0
Bulgaria0.9
Cape Verde Southeastern I…0.8
Guinea Bissau0.8
USA African Americans0.8
Peru Arequipa0.7
Turkey class I0.7
Cameroon Beti0.6
Spain Catalonia Girona0.6
USA Caucasians (3)0.6
Brazil0.5
Brazil Belo Horizonte0.5
Brazil Pernambuco State0.5
Croatia pop20.5
Guatemala Mayans0.4
Mongolia Buriat0.4
Allele frequencies presented, only

Further reading
  • Torimiro JN, Carr JK, Wolfe ND, et al. (2006). "HLA class I diversity among rural rainforest inhabitants in Cameroon: identification of A*2612-B*4407 haplotype". Tissue Antigens. 67 (1): 30–7. doi:10.1111/j.1399-0039.2005.00527.x. PMID 16451198.
  • Sanchez-Mazas A, Steiner QG, Grundschober C, Tiercy JM (October 2000). "The molecular determination of HLA-Cw alleles in the Mandenka (West Africa) reveals a close genetic relationship between Africans and Europeans". Tissue Antigens. 56 (4): 303–12. doi:10.1034/j.1399-0039.2000.560402.x. PMID 11098930.
  • Cao K, Moormann AM, Lyke KE, et al. (April 2004). "Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci". Tissue Antigens. 63 (4): 293–325. doi:10.1111/j.0001-2815.2004.00192.x. PMID 15009803.
  • Torimiro JN, Carr JK, Wolfe ND, et al. (January 2006). "HLA class I diversity among rural rainforest inhabitants in Cameroon: identification of A*2612-B*4407 haplotype". Tissue Antigens. 67 (1): 30–7. doi:10.1111/j.1399-0039.2005.00527.x. PMID 16451198.
  • Crespí C, Milà J, Martínez-Pomar N, et al. (October 2002). "HLA polymorphism in a Majorcan population of Jewish descent: comparison with Majorca, Minorca, Ibiza (Balearic Islands) and other Jewish communities". Tissue Antigens. 60 (4): 282–91. doi:10.1034/j.1399-0039.2002.600402.x. PMID 12472657.

References
  1. Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. Allele Query Form IMGT/HLA - European Bioinformatics Institute
  3. Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
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