HLA-A43

HLA-A43
HLA-A43
(MHC Class I, A cell surface antigen)
	HLA-A43
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*4301, β2-microglobulin
Older names	A10
Subtypes
Subtype
Subtype	allele
A43	*4301
{{{cNick2}}}	*43{{{cAllele2}}}
{{{cNick3}}}	*43{{{cAllele3}}}
{{{cNick4}}}	*43{{{cAllele4}}}
	Alleles link-out to IMGT/HLA database at EBI

HLA-A43 (A43) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁴³ subset of HLA-A α-chains. For A43, the alpha "A" chain are encoded by the HLA-A*43 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*4301. A43 and A*43 are almost synonymous in meaning. A43 is a split antigen of the broad antigen serotype A10. A43 is a sister serotype of A25, A26, A34, and A66.

A43 is more common in Africa and SouthWest Asia. A43 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[2].

Serotype

A43 recognition of some HLA A*43 gene products[3]
A*43	A43	A26	Sample
allele	%	%	size (N)
*4301	0	35	9

A43 serotyping is poor.

Distribution

HLA A*4301 frequencies
		freq
ref.	Population	(%)
[4]	South Africa Tswana	4.9
[4]	South African Natal Zulu	3.0
[4]	China Yunnan Han	1.2
[4]	Zambia Lusaka	1.2
[4]	Pakistan Karachi Parsi	0.6
[4]	India North Delhi	0.5
[4]	Zimbabwe Harare Shona	0.4
[4]	Italy	0.01
[4]	China Shanghai	0.002

References

Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. doi:10.1111/j.1399-0039.1993.tb01982.x. PMID 8475492.
Allele Query Form IMGT/HLA - European Bioinformatics Institute
Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. {{cite journal}}: External link in |title= (help)

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[pmid77067-1] Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.

[pmid8475492-2] Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. doi:10.1111/j.1399-0039.1993.tb01982.x. PMID 8475492.

[3] Allele Query Form IMGT/HLA - European Bioinformatics Institute

[pmid12753660-4] Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. {{cite journal}}: External link in |title= (help)