HNRNPL

Heterogeneous nuclear ribonucleoprotein L is a protein that in humans is encoded by the HNRNPL gene.[5][6]

HNRNPL
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHNRNPL, HNRPL, hnRNP-L, P/OKcl.14, heterogeneous nuclear ribonucleoprotein L
External IDsOMIM: 603083 MGI: 104816 HomoloGene: 1174 GeneCards: HNRNPL
Orthologs
SpeciesHumanMouse
Entrez

3191

15388

Ensembl

ENSG00000104824
ENSG00000282947

ENSMUSG00000015165

UniProt

P14866

Q8R081

RefSeq (mRNA)

NM_001005335
NM_001533

NM_177301

RefSeq (protein)

NP_001005335
NP_001524

Location (UCSC)Chr 19: 38.84 – 38.85 MbChr 7: 28.51 – 28.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogeneous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.[6]

Interactions

HNRNPL has been shown to interact with:

References

  1. ENSG00000282947 GRCh38: Ensembl release 89: ENSG00000104824, ENSG00000282947 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000015165 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pinol-Roma S, Swanson MS, Gall JG, Dreyfuss G (January 1990). "A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts". J Cell Biol. 109 (6 Pt 1): 2575–87. doi:10.1083/jcb.109.6.2575. PMC 2115934. PMID 2687284.
  6. "Entrez Gene: HNRPL heterogeneous nuclear ribonucleoprotein L".
  7. Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A (Aug 2008). "Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL". Science. 321 (5889): 686–91. Bibcode:2008Sci...321..686O. doi:10.1126/science.1157610. PMC 2791692. PMID 18669861.
  8. Kim JH, Hahm B, Kim YK, Choi M, Jang SK (May 2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm". J. Mol. Biol. 298 (3): 395–405. doi:10.1006/jmbi.2000.3687. PMID 10772858.
  9. Hahm B, Cho OH, Kim JE, Kim YK, Kim JH, Oh YL, Jang SK (April 1998). "Polypyrimidine tract-binding protein interacts with HnRNP L". FEBS Lett. 425 (3): 401–6. doi:10.1016/S0014-5793(98)00269-5. PMID 9563502. S2CID 4980318.

Further reading


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