Small nuclear ribonucleoprotein polypeptide E

SNRPE
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3CW1, 3PGW, 3S6N, 4F7U, 4PJO, 4V98, 4WZJ, 3JCR
Identifiers
Aliases	SNRPE, B-raf, HYPT11, SME, Sm-E, Small nuclear ribonucleoprotein polypeptide E, snRNP-E
External IDs	OMIM: 128260 MGI: 3650419 HomoloGene: 136765 GeneCards: SNRPE
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	203,871,152 bp[1]
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; body of pancreas; ; canal of the cervix; ; right adrenal gland; ; islet of Langerhans; ; appendix; ; left uterine tube; ; Achilles tendon; ; body of stomach; ; stromal cell of endometrium;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	cytoplasm; SMN-Sm protein complex; cytosol; catalytic step 2 spliceosome; U12-type spliceosomal complex; nucleoplasm; methylosome; U7 snRNP; small nuclear ribonucleoprotein complex; pICln-Sm protein complex; telomerase holoenzyme complex; spliceosomal complex; U4 snRNP; nucleus; U5 snRNP; U2 snRNP; U4/U6 x U5 tri-snRNP complex; precatalytic spliceosome; U1 snRNP; U2-type catalytic step 2 spliceosome; U2-type precatalytic spliceosome;
Biological process	hair cycle; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA processing; spliceosomal snRNP assembly; spliceosomal complex assembly; histone mRNA metabolic process; import into nucleus; RNA splicing;
	Sources:Amigo / QuickGO
Orthologs
	6635
	102632439
	ENSG00000182004
	n/a
	P62304
	n/a
	NM_001304464; NM_003094; NM_001328637; NM_001328638
	n/a
	NP_001291393; NP_001315566; NP_001315567; NP_003085
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Small nuclear ribonucleoprotein E is a protein that in humans is encoded by the SNRPE gene.[4][5][6]

Interactions

Small nuclear ribonucleoprotein polypeptide E has been shown to interact with DDX20[7] and Small nuclear ribonucleoprotein polypeptide F.[8]

References

GRCh38: Ensembl release 89: ENSG00000182004 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Fautsch MP, Wieben ED (December 1991). "Transcriptional regulation of the small nuclear ribonucleoprotein E protein gene. Identification of cis-acting sequences with homology to genes encoding ribosomal proteins". The Journal of Biological Chemistry. 266 (34): 23288–95. doi:10.1016/S0021-9258(18)54495-1. PMID 1835977.
Neiswanger K, Stanford DR, Sparkes RS, Nishimura D, Mohandas T, Klisak I, Heinzmann C, Wieben ED (August 1990). "Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43". Genomics. 7 (4): 503–8. doi:10.1016/0888-7543(90)90192-W. PMID 2143747.
"Entrez Gene: SNRPE small nuclear ribonucleoprotein polypeptide E".
Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.

Sauterer RA, Goyal A, Zieve GW (January 1990). "Cytoplasmic assembly of small nuclear ribonucleoprotein particles from 6 S and 20 S RNA-free intermediates in L929 mouse fibroblasts". The Journal of Biological Chemistry. 265 (2): 1048–58. doi:10.1016/S0021-9258(19)40157-9. PMID 1688550.
Stanford DR, Rohleder A, Neiswanger K, Wieben ED (July 1987). "DNA sequence of a human Sm autoimmune antigen. The multigene family contains a processed pseudogene". The Journal of Biological Chemistry. 262 (21): 9931–4. doi:10.1016/S0021-9258(18)61052-X. PMID 2440864.
Feeney RJ, Sauterer RA, Feeney JL, Zieve GW (April 1989). "Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles". The Journal of Biological Chemistry. 264 (10): 5776–83. doi:10.1016/S0021-9258(18)83617-1. PMID 2522439.
Stanford DR, Perry CA, Holicky EL, Rohleder AM, Wieben ED (November 1988). "The small nuclear ribonucleoprotein E protein gene contains four introns and has upstream similarities to genes for ribosomal proteins". The Journal of Biological Chemistry. 263 (33): 17772–9. doi:10.1016/S0021-9258(19)77902-2. PMID 2972723.
Stanford DR, Kehl M, Perry CA, Holicky EL, Harvey SE, Rohleder AM, Rehder K, Luhrmann R, Wieben ED (November 1988). "The complete primary structure of the human snRNP E protein". Nucleic Acids Research. 16 (22): 10593–605. doi:10.1093/nar/16.22.10593. PMC 338926. PMID 2974536.
Woppmann A, Rinke J, Lührmann R (December 1988). "Direct cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiation in situ". Nucleic Acids Research. 16 (23): 10985–1004. doi:10.1093/nar/16.23.10985. PMC 338992. PMID 2974540.
Kamiyama T, Aoki N, Yuasa Y (March 1993). "B-raf oncogene: activation by rearrangements and assignment to human chromosome 7". Japanese Journal of Cancer Research. 84 (3): 250–6. doi:10.1111/j.1349-7006.1993.tb02864.x. PMC 5919149. PMID 8098025.
Plessel G, Lührmann R, Kastner B (January 1997). "Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core". Journal of Molecular Biology. 265 (2): 87–94. doi:10.1006/jmbi.1996.0713. PMID 9020971.
Liu Q, Fischer U, Wang F, Dreyfuss G (September 1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129. S2CID 10855404.
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (February 1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403. S2CID 17379935.
Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (March 2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". The Journal of Cell Biology. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
Urlaub H, Raker VA, Kostka S, Lührmann R (January 2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". The EMBO Journal. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169.
Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (February 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". The Journal of Biological Chemistry. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (March 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (March 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". The Journal of Biological Chemistry. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (April 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182004 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1835977-4] Fautsch MP, Wieben ED (December 1991). "Transcriptional regulation of the small nuclear ribonucleoprotein E protein gene. Identification of cis-acting sequences with homology to genes encoding ribosomal proteins". The Journal of Biological Chemistry. 266 (34): 23288–95. doi:10.1016/S0021-9258(18)54495-1. PMID 1835977.

[pmid2143747-5] Neiswanger K, Stanford DR, Sparkes RS, Nishimura D, Mohandas T, Klisak I, Heinzmann C, Wieben ED (August 1990). "Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43". Genomics. 7 (4): 503–8. doi:10.1016/0888-7543(90)90192-W. PMID 2143747.

[entrez-6] "Entrez Gene: SNRPE small nuclear ribonucleoprotein polypeptide E".

[pmid10601333-7] Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.

[pmid9417867-8] Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.

RNA-binding protein: Ribonucleoproteins
snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200
hnRNP	A0 C L R
Other transcription	Telomerase
Translation	Ribosome
Vault ribonucleoprotein particles	Major vault protein
Other	Signal recognition particle

Small nuclear ribonucleoprotein polypeptide E

Interactions

References

Further reading