SNRPB

Small nuclear ribonucleoprotein-associated proteins B and B' is a protein that in humans is encoded by the SNRPB gene.[5][6]

SNRPB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSNRPB, COD, SNRPB1, Sm-B/B', SmB/B', SmB/SmB', snRNP-B, CCMS, small nuclear ribonucleoprotein polypeptides B and B1
External IDsOMIM: 182282 MGI: 98342 HomoloGene: 134543 GeneCards: SNRPB
Orthologs
SpeciesHumanMouse
Entrez

6628

20638

Ensembl

ENSG00000125835

ENSMUSG00000027404

UniProt

P14678

P27048

RefSeq (mRNA)

NM_198216
NM_003091

NM_009225

RefSeq (protein)

NP_003082
NP_937859

NP_033251

Location (UCSC)Chr 20: 2.46 – 2.47 MbChr 2: 130.01 – 130.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene.[6]

Interactions

SNRPB has been shown to interact with DDX20[7] and Coilin.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000125835 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027404 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Griffith AJ, Schmauss C, Craft J (July 1992). "The murine gene encoding the highly conserved Sm B protein contains a nonfunctional alternative 3' splice site". Gene. 114 (2): 195–201. doi:10.1016/0378-1119(92)90574-9. PMID 1376292.
  6. "Entrez Gene: SNRPB small nuclear ribonucleoprotein polypeptides B and B1".
  7. Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (Dec 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
  8. Hebert MD, Szymczyk PW, Shpargel KB, Matera AG (October 2001). "Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein". Genes Dev. 15 (20): 2720–9. doi:10.1101/gad.908401. PMC 312817. PMID 11641277.

Further reading


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