Haplogroup H (mtDNA)

Projected spatial frequency distribution of haplogroup H1

H1 encompasses an important fraction of Western European mtDNA lineages, reaching its local peak among contemporary Basques (27.8%). The clade also occurs at high frequencies elsewhere in the Iberian Peninsula, as well as in the Maghreb (Tamazgha). The haplogroup frequency is above 10% in many other parts of Europe (France, Sardinia, parts of the British Isles, Alps, large portions of Eastern Europe), and surpasses 5% in nearly all of the continent.[1] Its H1b subclade is most common in eastern Europe and NW Siberia.[20]

As of 2010, the highest frequency of the H1 subclade has been found among the Tuareg inhabiting the Fezzan region in Libya (61%).[21] The basal H1* haplogroup is found among the Tuareg inhabiting the Gossi area in Mali (4.76%).[22]

The rare H1cb subclade is concentrated among Fulani groups inhabiting the Sahel.[23]

Haplogroup H has been found in various fossils that were analysed for ancient DNA, including specimens associated with the Linearbandkeramik culture (H1e, Halberstadt-Sonntagsfeld, 1/22 or ~5%; H1 or H1au1b, Karsdorf, 1/2 or 50%), Germany Middle Neolithic (H1e1a, Esperstedt, 1/1 or 100%), Iberia Early Neolithic (H1, El Prado de Pancorbo, 1/2 or 50%), Iberia Middle Neolithic (H1, La Mina, 1/4 or 25%), and Iberia Chalcolithic (H1t, El Mirador Cave, 1/12 or ~8%).[24] Haplogroup H has been observed in ancient Guanche fossils excavated in Gran Canaria and Tenerife on the Canary Islands, which have been radiocarbon-dated to between the 7th and 11th centuries CE. At the Tenerife site, these clade-bearing individuals were found to belong to the H1cf subclade (1/7; ~14%); at the Gran Canaria site, the specimens carried the H2a subhaplogroup (1/4; 25%).[25] Additionally, ancient Guanche (Bimbaches) individuals excavated in Punta Azul, El Hierro, Canary Islands were all found to belong to the H1 maternal subclade. These locally born individuals were dated to the 10th century and carried the H1-16260 haplotype, which is exclusive to the Canary Islands and Algeria.[26]

Frequencies of haplogroup H1 in the world (Ottoni et al. 2010)

H3 is found throughout the whole of Europe and in the Maghreb but does not exist in the Far East ,[1] and is believed to have originated among Mesolithic hunter-gatherers in south-western Europe between 9 000 and 11 000 years ago. H3 represents the second largest fraction of the H genome after H1 and has a somewhat similar distribution, with peaks in Portugal, Spain, Scandinavia and Finland. It is common in Portugal (12%), Sardinia (11%), Galicia (10%), the Basque country (10%), Ireland (6%), Norway (6%), Hungary (6%) and southwestern France (5%).[1][27][28] Studies have suggested haplogroup H3 is highly protective against AIDS progression.[29]

Example of H3 sub-groups are:[28]

• H3a and H3g, found in north-west Europe;
• H3b and H3k, found in the British Isles and Catalonia;
• H3c, found in Western Europe, including among the Basques;
• H3h, found throughout northern Europe, including the remains of Cerdic (519 to 534), King of Wessex;[30]
• H3i found in Ireland and Scotland;
• H3j found in Italy;
• H3v found especially in Germanic countries and;
• H3z found in Atlantic Europe.

The basal H3* haplogroup is found among the Tuareg inhabiting the Gossi area in Mali (4.76%).[22]

H5 may have evolved in West Asia, where it is most frequent and diverse in the Western Caucasus. However, its H5a subclade has a stronger representation in Europe, though at low levels.[31]

The H2, H6 and H8 haplogroups are somewhat common in Eastern Europe and the Caucasus.[19] They may be the most common H subclades among Central Asians and have also been found in West Asia.[20] H2a5 has been found in the Basque Country, [32] and in Norway, Ireland and Slovakia.[3] H6a1a1a is common among Ashkenazi Jews.[33]

H4 is often found in the Iberian peninsula,[32] Britain and Ireland at levels between 1-5% of the population. It is associated with Neolithic migrations.

H4 and H13, along with H2 account for 42% of the hg H lineages in Egypt.[34]

The H7 subhaplogroup is present in both Europe and West Asia. Its subclade H7c1 is present in Druze people and in Saudi Arabia.[35] H7c2 is present in such peoples as Ashkenazi Jews, Sardinians, and Dutch people.[36] H7e is present in Ashkenazi Jews, Germans, Sardinians, and others.[37] H7a1b is found today in Scotland, England, Denmark, Finland and Sardinia.[38]

H9 is present in Yemenis.[39] The subclade H9a exists in Welsh people,[40] Calabrians[41] and Crimean Karaites.[42][43] H9a samples were recovered from two ancient people in Lebanon.[44]

Haplogroup H10 is subclade which came into existence between 6,300 and 10,900 years ago. Its descendant branches are H10a, H10b, H10c, H10d, H10e, H10f, H10g, and H10h.[45]

Haplogroup H10e has been found at a neolithic site, namely the Bom Santo cave near Lisbon. This is the oldest sample of H10 which has ever been found and it has been dated to 3735 BCE (+- 45 years).[46]

H11 is commonly found in Central Europe.[32]

Italians are notable carriers of H12 and its two branches. H12a has been detected in such regions as Sicily[47] and Calabria.[48]

The H13 subhaplogroup is present in both Europe and West Asia. H13 is also found in the Caucasus; H13c was found in a 9,700 year old sample in Mesolithic Georgia[49] and H13a2a and H13a2b are found in Armenians in Armenia.[50][51]

The root level of H14 is found in northwestern Europeans, such as in Ireland.[52]

Its subclade H14a is encountered among such populations as Armenians from Turkey,[53] Sardinians from Italy,[54] and Persian Jews and Iraqi Jews.[55] The branch H14a2 is present among Romani people from Spain[56] and Croats[57] and is common in Iran.[52]

Its subclade H14b has a presence in many European and West Asian populations including Assyrian people,[58] Persians[59] and Armenians from Iran,[60] and people in Tuscany (central Italy),[61] Switzerland, Germany, Ireland, Spain, and Qatar.[52] The branch H14b1 is especially prevalent in France but also found in neighboring Monaco and in Scotland.[52] The branch H14b3 has been found in Armenians from Artsakh[62] and people from Armenia, Turkey, Saudi Arabia, Italy, and Scotland.[52] H14b4 is in Italy and Germany.[52]

H15 includes the base level and the branches H15a and H15b. H15a1b is present in Greeks.[63] H15b is present in Armenians, Druze, Ashkenazi Jews, Danes, and other peoples of Europe and the Near East.[64]

H16 is encountered in numerous European populations, such as Norway and England.[52] Its subclade H16a is found in Czechs[65] and in Germany, Scotland, and the Netherlands.[52] H16a1 is similarly found in Europe, including in Denmark.[66] H16b is another common branch and among other places is present in Sardinia.[67] H16c was found in archaeological human remains from Iron Age cemetery in Lejasbitēni, Latvia,[68] it is currently found in Sweden, Great Britain, Lithuania, Poland, Germany, Latvia and elsewhere.[52] H16d is found in Italy, France, Ireland, England, and other parts of Europe.[52] H16e is especially commmon in Sweden.[52]

In July 2008 ancient mtDNA from an individual called Paglicci 23, whose remains were dated to 28,000 years ago and excavated from Paglicci Cave (Apulia, Italy), were found to be identical to the Cambridge Reference Sequence in HVR1.[5]

H17 is especially prevalent in Ireland but also found in England, Scotland, Wales, Sweden, and Germany.[52] H17a is similarly found across Europe, such as in Sardinia[69] and Lithuania.[52]

H18 occurs on the Arabian Peninsula. [70]

These haplogroups are both found in the Caucasus region.[31] H20 also appears at low levels in the Iberian Peninsula (less than 1%), Arabian Peninsula (1%) and Near East (2%).[70]

These subclades are found mostly in Europe, South-West Asia and Central Asia.

H24 is found in Romance-speaking countries' populations (France, Spain, and Romani people from Spain)[71] as well as in Germany, Ireland, Scotland, and England.[52]

H45 is found in Ireland and Spain.[52] Its subclade H45a is especially found in Finland[72] but also found in Sweden.[52] H45b exists among multiple kinds of western Europeans, including people in Ireland,[73] Scotland, England, and Germany.[52]

H47 has been found in Syria, Italy, and Armenians and infrequently in Ashkenazi Jews.[74] Its subclade H47a is exclusively European, being found in such countries as England, Ireland, Czechia, and Bulgaria.[52]

H53 is encountered in such countries as Spain (including among Basques)[75] and Poland[76] and as far east as Xinjiang in western China (among Uyghurs).[77]

H69 is a European branch found in Finns,[78] Irish people,[79] and inhabitants of Sweden, Germany, and Switzerland.[52]

H91a is associated with the Uyghur ethnic minority of western China.[80]

These were the most recently discovered and named major branches of H.

H105 is found in Italy and Hungary.[52]

H106 is found in Italy, France, Austria, England, and Germany.[52]

H107 is encountered in Russia.[81]