Integrin alpha X

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c .[5][6]

ITGAX
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesITGAX, CD11C, SLEB6, integrin subunit alpha X
External IDsOMIM: 151510 MGI: 96609 HomoloGene: 55493 GeneCards: ITGAX
Orthologs
SpeciesHumanMouse
Entrez

3687

16411

Ensembl

ENSG00000140678

ENSMUSG00000030789

UniProt

P20702

Q9QXH4

RefSeq (mRNA)

NM_000887
NM_001286375

NM_021334
NM_001363984
NM_001363985

RefSeq (protein)

NP_000878
NP_001273304

NP_067309
NP_001350913
NP_001350914

Location (UCSC)Chr 16: 31.36 – 31.38 MbChr 7: 127.73 – 127.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.[5]

CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000140678 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030789 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)".
  6. Dyer KD, Garcia-Crespo KE, Killoran KE, Rosenberg HF (2011). "Antigen profiles for the quantitative assessment of eosinophils in mouse tissues by flow cytometry". Journal of Immunological Methods. 369 (1–2): 91–7. doi:10.1016/j.jim.2011.04.009. PMC 3116057. PMID 21565196.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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