CD98

CD98 is a glycoprotein[1][2] that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine, phenylalanine) amino acids.[3] LAT is highly expressed in brain capillaries (which form the blood–brain barrier) relative to other tissues.[3]

solute carrier family 3 member 2 (activators of dibasic and neutral amino acid transport)
Identifiers
SymbolSLC3A2
Alt. symbolsMDU1, 4T2HC, 4F2, NACAE, CD98
NCBI gene6520
HGNC11026
OMIM158070
RefSeqNM_001013251
UniProtP08195
Other data
LocusChr. 11 q12-q22
Search for
StructuresSwiss-model
DomainsInterPro
solute carrier family 7 member 5 (cationic amino acid transporter, y+ system)
Identifiers
SymbolSLC7A5
Alt. symbolsLAT1, E16, D16S469E, MPE16, CD98
NCBI gene8140
HGNC11063
OMIM600182
RefSeqNM_003486
UniProtQ01650
Other data
LocusChr. 16 q24.3
Search for
StructuresSwiss-model
DomainsInterPro

A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:

  • 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene [4]
  • CD98 light subunit protein encoded by the SLC7A5 gene[5]

See also

References
  1. Kucharzik T, Lugering A, Yan Y, Driss A, Charrier L, Sitaraman S, Merlin D (2005). "Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation". Lab. Invest. 85 (7): 932–41. doi:10.1038/labinvest.3700289. PMID 15880135.
  2. Lemaître G, Gonnet F, Vaigot P, Gidrol X, Martin MT, Tortajada J, Waksman G (2005). "CD98, a novel marker of transient amplifying human keratinocytes". Proteomics. 5 (14): 3637–45. doi:10.1002/pmic.200401224. PMID 16097038. S2CID 31954787.
  3. Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM (1999). "Selective expression of the large neutral amino acid transporter at the blood–brain barrier". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 12079–84. Bibcode:1999PNAS...9612079B. doi:10.1073/pnas.96.21.12079. PMC 18415. PMID 10518579.
  4. Palacin M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflügers Arch. 447 (5): 490–494. doi:10.1007/s00424-003-1062-7. PMID 14770309. S2CID 25808108.
  5. Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters" (PDF). Pflügers Arch. 447 (5): 532–542. doi:10.1007/s00424-003-1086-z. PMID 14770310. S2CID 11670040.


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