CCL3

Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.[3]

CCL3
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3, C-C motif chemokine ligand 3
External IDsOMIM: 182283 HomoloGene: 88430 GeneCards: CCL3
Orthologs
SpeciesHumanMouse
Entrez

6348

n/a

Ensembl

ENSG00000278567
ENSG00000277632
ENSG00000274221

n/a

UniProt

P10147

n/a

RefSeq (mRNA)

NM_002983

n/a

RefSeq (protein)

NP_002974

n/a

Location (UCSC)Chr 17: 36.09 – 36.09 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes[4] through binding to the receptors CCR1, CCR4 and CCR5.[3]

Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4).[5][3]

CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.[6]

Interactions

CCL3 has been shown to interact with CCL4.[7] Attracts macrophages, monocytes and neutrophils.

See also

References

  1. ENSG00000277632, ENSG00000274221 GRCh38: Ensembl release 89: ENSG00000278567, ENSG00000277632, ENSG00000274221 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3".
  4. Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A (1988). "Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties". The Journal of Experimental Medicine. 167 (2): 570–81. doi:10.1084/jem.167.2.570. PMC 2188834. PMID 3279154.
  5. Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A (1988). "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta". The Journal of Experimental Medicine. 168 (6): 2251–9. doi:10.1084/jem.168.6.2251. PMC 2189160. PMID 3058856.
  6. Davatelis G, Wolpe SD, Sherry B, Dayer JM, Chicheportiche R, Cerami A (1989). "Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen". Science. 243 (4894 Pt 1): 1066–8. Bibcode:1989Sci...243.1066D. doi:10.1126/science.2646711. PMID 2646711.
  7. Guan E, Wang J, Norcross MA (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry. 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.

Further reading


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