Meenakshi Ponnunga

• Mokshitha Pai (2022)[4] / Soundarya Reddy (2022–present)[5] as Shakthi – Meenakshi and Needhimani's second daughter; Yamuna's younger sister; Durga's elder sister; Vetri's love interest and wife; Ranganayagi's daughter-in-law
• Archana (2022–2023)[6] / Sriranjani (2023–present)[7] as Meenakshi – Needhimani's first wife; Yamuna, Shakthi and Durga's mother; Karthik and Vetri's mother-in-law
• Aryan [8] as Vetri – Ranganayaki's son; Saranya's brother; Pooja's ex-fiancé; Shakthi's husband

• Gayathri Yuvraaj[9] / Kavya Bellu as Yamuna – Meenakshi and Needhimani's first daughter; Shakthi and Durga's elder sister; Karthik's love interest and wife
• Pranika Dhakshu as Durga – Meenakshi and Needhimani's last daughter; Shakthi and Yamuna's younger sister
• Sasilaya as Ranganayagi – Vetri and Saranya's mother; Shakthi and Ashok's mother-in-law
• Anandmouli as Singaraja - Ranganayagi's husband
• Subathira as Pushpa − Needhimani's second wife; Shanmugam's mother (Main Antagonist)
• Ram Sundar as Sangili - Pushpa's brother, who wants to marry one of Meenakshi's daughters, with the intention of making their life hell.
• Prabhakaran as Needhimani – Meenakshi and Pushpa's husband; Yamuna, Shakthi, Durga and Shanmugam's father; Karthik and Vetri's father-in-law
• Suganya as Saranya – Ranganayagi's daughter; Vetri's sister; Ashok's wife
• Hema Dayal as Pooja – Vetri's ex-fiancée
• Sudharsanam / Vishnukanth as Karthik – Kokila's son; Yamuna's husband
• Aarthi Ramkumar as Kokila – Karthik's mother
• Singaraja as Kokila's husband and Karthik's father
• Deepa Shankar as Shantha – Meenakshi's friend and maid
• Vigneshwaran as Ashok – Saranya's husband
• Thidiyan as Thidiyan – Vetri's friend
• Tom Frank as Giri -Vetri's friend
• Sanjay as Shanmugam – Needhimani and Pushpa's son
• Siddharth Kapilavayi as Rohit – Pooja's ex-fianceè

After the ending of the longest running Zee Tamil TV drama Sembaruthi, its Production Company Insidues Media decide to produce Meenakshi Ponnunga. The series was directed by Neethane Enthan Ponvasantham fame L. Muthukumaraswamy.

Actress Archana was signed to portray the title role of Meenakshi in her first television debut. She quit the serial in April 2023 due to being unsatisfied with the storyline and in June 2023, she was replaced by Sriranjani.[11] Mokshitha Pai was initially selected to play the role Shakthi, by marking her debut in Tamil television but later was replaced by Soundarya Reddy in November 2022 who also made her debut in Tamil television as Mokshitha Pai quit the serial.[12][13] Aryan was selected to play the character Vetri, whilst Tamil motivational speaker Sasilaya was chosen to play the role of Renganayagi, Vetri's mother.[14][15]

Actress Gayathri Yuvaraj was initially played the role as Yamuna.[16] Later due to her pregnancy situations she need to stay in home, so she quit the series in September 2023, she was replaced by Kavya Bellu.[17]

Zee Tamil was promoted their new three fictions Maari, Amudhavum Annalakshmiyum and including this series by making advertisement with actress Sneha, Saranya Ponvannan and Sangeetha with the slogan "Vanga Paarkalaam Ithu Namma Time" and this promo released on 26 June 2022.[18]