NLRC3

NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system.[5] It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells.[6] NLRC3 also inhibits the mTOR signalling pathway to block cellular proliferation.[7]

NLRC3
Identifiers
AliasesNLRC3, CLR16.2, NOD3, NLR family, CARD domain containing 3, NLR family CARD domain containing 3
External IDsOMIM: 615648 MGI: 2444070 HomoloGene: 18720 GeneCards: NLRC3
Orthologs
SpeciesHumanMouse
Entrez

197358

268857

Ensembl

ENSG00000167984

ENSMUSG00000049871

UniProt

Q7RTR2

Q5DU56

RefSeq (mRNA)

NM_178844

NM_001081280
NM_175547

RefSeq (protein)

NP_849172

NP_001074749
NP_780756

Location (UCSC)Chr 16: 3.54 – 3.58 MbChr 16: 3.76 – 3.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000167984 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000049871 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ting JP, Lovering RC, Alnemri ES, et al. (March 2008). "The NLR gene family: a standard nomenclature". Immunity. 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772. PMID 18341998.
  6. Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (May 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.
  7. Karki, Rajendra; Man, Si Ming; Malireddi, R. K. Subbarao; Kesavardhana, Sannula; Zhu, Qifan; Burton, Amanda R.; Sharma, Bhesh Raj; Qi, Xiaopeng; Pelletier, Stephane; Vogel, Peter; Rosenstiel, Philip (December 2016). "NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer". Nature. 540 (7634): 583–587. doi:10.1038/nature20597. ISSN 1476-4687. PMC 5468516. PMID 27951586.


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