NLRP6

NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors. As with several other NOD-like receptors, NLRP6's role in immunity is related to its ability to regulate caspase-1 and NF-κB activity.[5]

NLRP6
Identifiers
AliasesNLRP6, AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5, NLR family, pyrin domain containing 6, NLR family pyrin domain containing 6
External IDsOMIM: 609650 MGI: 2141990 HomoloGene: 15881 GeneCards: NLRP6
Orthologs
SpeciesHumanMouse
Entrez

171389

101613

Ensembl

ENSG00000174885

ENSMUSG00000038745

UniProt

P59044

Q91WS2

RefSeq (mRNA)

NM_001276700
NM_138329

NM_001081389
NM_133946

RefSeq (protein)

NP_001263629
NP_612202

NP_598707

Location (UCSC)Chr 11: 0.28 – 0.29 MbChr 7: 140.5 – 140.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000174885 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038745 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Grenier JM, Wang L, Manji GA, et al. (October 2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1–3): 73–8. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869. S2CID 25023390.

Further reading


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