NLRP4

NACHT, LRR and PYD domains-containing protein 4 is a protein that in humans is encoded by the NLRP4 gene.[5][6][7]

NLRP4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNLRP4, CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2, NLR family, pyrin domain containing 4, NLR family pyrin domain containing 4
External IDsOMIM: 609645 MGI: 1890518 HomoloGene: 75315 GeneCards: NLRP4
Orthologs
SpeciesHumanMouse
Entrez

147945

83564

Ensembl

ENSG00000160505

ENSMUSG00000034690

UniProt

Q96MN2

Q3TKR3

RefSeq (mRNA)

NM_134444

NM_031389

RefSeq (protein)

NP_604393

NP_113566

Location (UCSC)Chr 19: 55.84 – 55.88 MbChr 7: 6.05 – 6.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region.

The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000160505 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034690 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.
  6. Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J Biol Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.
  7. "Entrez Gene: NLRP4 NLR family, pyrin domain containing 4".

Further reading


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