Patrik Rorsman

Patrik Rorsman (born 1959)[2] FRS FMedSci is Professor of Diabetic Medicine at the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), in the Radcliffe Department of Medicine at the University of Oxford[3][6][7] and a fellow of Harris Manchester College, Oxford.[8][9]

Patrik Rorsman
Patrik Rorsman at the Royal Society admissions day in London, July 2014
Born (1959-05-14) 14 May 1959[1][2]
Lund, Sweden[1]
NationalitySwedish[3]
Alma materUppsala University (PhD)
Awards
Scientific career
Fields
Institutions
ThesisPatch-clamp studies on pancreatic glucagon- and insulin-secreting cells (1986)
Doctoral advisorBert Sakmann
Websiteocdem.ox.ac.uk/patrik-rorsman

Education

Rorsman was educated at Uppsala University in Sweden where he was awarded a PhD under the supervision of Nobel laureate Bert Sakmann in 1986 for patch clamp studies of pancreatic cells and their secretion of glucagon and insulin.[10]

Career

Rorsman was for short time the Canadian Excellence in Research Chair (CERC) in Diabetes[3][11][12] at the University of Alberta in Edmonton, before being reappointed a Professor at the University of Oxford in 2011.[3]

Research

Rorsman's research investigates exocytosis, ion channels and diabetes mellitus type 2.[5][13][14][15][16][17][18][19][20][21] His research been funded by the Medical Research Council (MRC),[22] the Royal Society, the Wolfson Foundation, the Knut and Alice Wallenberg Foundation,[1] the Wellcome Trust and the Government of Canada.[9]

Awards and honours

Rorsman was elected a Fellow of the Royal Society (FRS) in 2014. His nomination reads:

Patrik Rorsman is an outstanding cell physiologist who has made distinguished contributions to our understanding of how the insulin- and glucagon-producing cells of the pancreatic islets regulate the plasma glucose concentration. His pioneering work is a shining example of post-genomic experimental diabetes research that integrates an unusual breadth of sophisticated methods and has clinical implications. It has led to the identification of key processes that become disrupted in type 2 diabetes, and shed light on the causal relationship between obesity and diabetes. He has also trained a school of excellent young investigators.[4]

Rorsman was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2010. His nomination reads:

Patrik Rorsman is Professor of Diabetic Medicine at the University of Oxford. He has been at the forefront of pancreatic islets research for more than 20 years. His work integrates an unusual variety and breadth of sophisticated high-resolution methods including the whole-islet patch-clamp technique which has helped to bridge the gap between patch-clamp measurements on isolated cultured cells and hormone release by whole islets. Patrik's work also covers human islet cells, which has revealed important differences between ß-cells in man and experimental animals that are likely to be highly relevant to the understanding of the causes and treatment of human diabetes.[23]

Rorsman was awarded the Minkowski Prize in 1996, the Göran Gustafsson Prize in 2003 and the Albert Renold Prize in 2013.

References
  1. Wallenberg researcher aiming to solve the riddle of diabetes, akademimiliv.se
  2. "RORSMAN, Prof. Patrik". Who's Who. Vol. 2017 (online Oxford University Press ed.). Oxford: A & C Black. (Subscription or UK public library membership required.)
  3. Gewin, V. (2012). "Turning point: Patrik Rorsman". Nature. 492 (7428): 301. doi:10.1038/nj7428-301a.
  4. "Professor Patrik Rorsman FMedSci FRS". London: The Royal Society. Archived from the original on 4 November 2014.
  5. Professor Patrik Rorsman (OXION Member), University of Oxford
  6. Patrik Rorsman's publications indexed by the Scopus bibliographic database. (subscription required)
  7. Patrik Rorsman publications indexed by Microsoft Academic
  8. Professor Patrik Rorsman, Harris Manchester College, University of Oxford
  9. Patrik Rorsman leaves $10M Edmonton research grant behind, returns to England, National Post, 2012-11-14
  10. Rorsman, Patrik (1986). Patch-clamp studies on pancreatic glucagon- and insulin-secreting cells (PhD thesis). Uppsala University.
  11. The value of the Canada Excellence Research Chairs (CERC) program, The Lab and Field
  12. Patrik Rorsman is the new Canada Excellence Research Chair in Diabetes on YouTube, University of Alberta
  13. Ashcroft, F. M.; Rorsman, P. (1989). "Electrophysiology of the pancreatic β-cell". Progress in Biophysics and Molecular Biology. 54 (2): 87–143. doi:10.1016/0079-6107(89)90013-8. PMID 2484976.
  14. Poy, M. N.; Eliasson, L.; Krutzfeldt, J.; Kuwajima, S.; Ma, X.; MacDonald, P. E.; Pfeffer, S. B.; Tuschl, T.; Rajewsky, N.; Rorsman, P.; Stoffel, M. (2004). "A pancreatic islet-specific microRNA regulates insulin secretion". Nature. 432 (7014): 226–30. Bibcode:2004Natur.432..226P. doi:10.1038/nature03076. PMID 15538371. S2CID 4415988.
  15. Rorsman, P.; Renstrom, E. (2003). "Insulin granule dynamics in pancreatic beta cells". Diabetologia. 46 (8): 1029–45. doi:10.1007/s00125-003-1153-1. PMID 12879249.
  16. Ämmälä, C.; Ashcroft, F. M.; Rorsman, P. (1993). "Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells". Nature. 363 (6427): 356–358. Bibcode:1993Natur.363..356A. doi:10.1038/363356a0. PMID 7684514. S2CID 4341009.
  17. Rorsman, P.; Berggren, P. O.; Bokvist, K.; Ericson, H.; Möhler, H.; Östenson, C. G. R.; Smith, P. A. (1989). "Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels". Nature. 341 (6239): 233–6. Bibcode:1989Natur.341..233R. doi:10.1038/341233a0. PMID 2550826. S2CID 699135.
  18. MacDonald, P. E.; Joseph, J. W.; Rorsman, P. (2005). "Glucose-sensing mechanisms in pancreatic -cells". Philosophical Transactions of the Royal Society B: Biological Sciences. 360 (1464): 2211–25. doi:10.1098/rstb.2005.1762. PMC 1569593. PMID 16321791.
  19. Gerken, T.; Girard, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, C. P.; Ashcroft, F. M.; O'Rahilly, S.; Schofield, C. J. (2007). "The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. Bibcode:2007Sci...318.1469G. doi:10.1126/science.1151710. PMC 2668859. PMID 17991826.
  20. Patrik Rorsman: Diabetes and Insulin Secretion on YouTube, University of Oxford
  21. Interview with Patrik Rorsman on YouTube, Scandinavian Physiological Society
  22. UK Government research grants awarded to Patrik Rorsman, via Research Councils UK
  23. "Professor Patrik Rorsman FRS FMedSci". London: The Academy of Medical Sciences. Archived from the original on 4 November 2014.
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