Peter Keightley

Peter D. Keightley FRS[1] is Professor of Evolutionary Genetics at the Institute of Evolutionary Biology in School of Biological Sciences at the University of Edinburgh.[2]

Peter Keightley
Peter Keightley at the Royal Society admissions day in London, July 2014
Born
Peter D. Keightley
Alma materUniversity of Edinburgh (PhD)
AwardsFRS (2014)[1]
Scientific career
Fields
InstitutionsUniversity of Edinburgh
ThesisStudies of quantitative genetic variation (1989)
Doctoral advisorWilliam G. Hill, also influenced by Henrik Kacser
Websitewww.homepages.ed.ac.uk/pkeightl

Education

Keightley was educated at the University of Edinburgh where he was awarded a PhD in 1989 for research on genetic variation[3] supervised by William G. Hill.[3] During his doctoral work he collaborated with Henrik Kacser on a highly cited paper on genetic dominance.[4]

Research

Keightley leads a laboratory which works on evolutionary genetics and the evolutionary impact of new mutations on molecular genetic and quantitative trait variation and fitness. His research investigates genetic variation and adaptation through the analysis of nucleotide variation within natural populations and between different species.[5][6][7][8][9][10][11][12]

Keightley's research has been funded by the Biotechnology and Biological Sciences Research Council (BBSRC).[13]

Awards and honours

Keightley was elected a Fellow of the Royal Society in 2014. His nomination reads:

Peter Keightley is a leading evolutionary geneticist. He has made seminal contributions to the genetics and evolution of quantitative traits, and to molecular evolution and variation. His work combines theoretical modelling, genetic experimentation and bioinformatic studies of DNA sequences, in an unusually productive and innovative way. His work has shed light on several fundamental questions in genetics and evolution. He is especially well known for his work on the effects on fitness and rate of occurrence of spontaneous mutations. This has led to a much improved estimate of the deleterious mutation rate for the genome as a whole.[1]


References
  1. Anon (2014). "Professor Peter Keightley FRS". royalsociety.org. London: Royal Society.
  2. Peter Keightley publications indexed by the Scopus bibliographic database. (subscription required)
  3. Keightley, Peter (1988). Studies of quantitative genetic variation (PhD thesis). University of Edinburgh. hdl:1842/12340. open access
  4. Keightley, P D; Kacser, H (1987). "Dominance, pleiotropy and metabolic structure". Genetics. 117 (2): 319–329. doi:10.1093/genetics/117.2.319. PMC 1203207. PMID 3666444.
  5. Drosophila 12 Genomes, Consortium; Clark, A. G.; Eisen, M. B.; Smith, D. R.; Bergman, C. M.; Oliver, B; Markow, T. A.; Kaufman, T. C.; Kellis, M; Gelbart, W; Iyer, V. N.; Pollard, D. A.; Sackton, T. B.; Larracuente, A. M.; Singh, N. D.; Abad, J. P.; Abt, D. N.; Adryan, B; Aguade, M; Akashi, H; Anderson, W. W.; Aquadro, C. F.; Ardell, D. H.; Arguello, R; Artieri, C. G.; Barbash, D. A.; Barker, D; Barsanti, P; Batterham, P; et al. (2007). "Evolution of genes and genomes on the Drosophila phylogeny". Nature. 450 (7167): 203–18. Bibcode:2007Natur.450..203C. doi:10.1038/nature06341. PMID 17994087.
  6. Barton, N. H.; Keightley, P. D. (2002). "Understanding quantitative genetic variation". Nature Reviews Genetics. 3 (1): 11–21. doi:10.1038/nrg700. PMID 11823787. S2CID 8934412.
  7. Eyre-Walker, A.; Keightley, P. (August 2007). "The distribution of fitness effects of new mutations". Nature Reviews Genetics. 8 (8): 610–618. doi:10.1038/nrg2146. ISSN 1471-0056. PMID 17637733. S2CID 10868777.
  8. Eyre-Walker, A; Keightley, P. D. (1999). "High genomic deleterious mutation rates in hominids". Nature. 397 (6717): 344–7. Bibcode:1999Natur.397..344E. doi:10.1038/16915. PMID 9950425. S2CID 4314159.
  9. Millar, C. B.; Guy, J; Sansom, O. J.; Selfridge, J; MacDougall, E; Hendrich, B; Keightley, P. D.; Bishop, S. M.; Clarke, A. R.; Bird, A (2002). "Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice". Science. 297 (5580): 403–5. Bibcode:2002Sci...297..403M. doi:10.1126/science.1073354. hdl:1842/462. PMID 12130785. S2CID 40023026.
  10. Haag-Liautard, C; Dorris, M; Maside, X; MacAskill, S; Halligan, D. L.; Houle, D; Charlesworth, B; Keightley, P. D. (2007). "Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila". Nature. 445 (7123): 82–5. Bibcode:2007Natur.445...82H. doi:10.1038/nature05388. PMID 17203060. S2CID 4406612.
  11. Keightley, P. D. (1994). "The distribution of mutation effects on viability in Drosophila melanogaster". Genetics. 138 (4): 1315–22. doi:10.1093/genetics/138.4.1315. PMC 1206267. PMID 7896110.
  12. Keightley, Peter D.; Otto, Sarah P. (2006). "Interference among deleterious mutations favours sex and recombination in finite populations". Nature. 443 (7107): 89–92. Bibcode:2006Natur.443...89K. doi:10.1038/nature05049. PMID 16957730. S2CID 4422532.
  13. UK Government research grants awarded to Peter Keightley Archived 27 July 2014 at the Wayback Machine, via Research Councils UK


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