Rajesh Thakker

Rajesh Vasantlal Thakker FRS FMedSci FRCPath FRCPE FRCP[3] (born 1954) is May Professor of Medicine in the Nuffield Department of Clinical Medicine at the University of Oxford and a fellow of Somerville College, Oxford.[4] Thakker is also a Consultant physician at the Churchill Hospital and the John Radcliffe Hospital, Principal investigator (PI) at the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) and was Chairman of the NIHR/MRC Efficacy and Mechanism Evaluation (EME) Board until Spring 2016.[5][6][7][8][9][10][11][12]

Rajesh Thakker

FRS FMedSci FRCPath FRCPE FRCP
Professor Rajesh Thakker in 2014, portrait via the Royal Society
Born
Rajesh Vasantlal Thakker

(1954-08-27) 27 August 1954[1]
Alma materUniversity of Cambridge (MA, MB BChir, MD, ScD)
SpouseJulie Clare Magee[1]
AwardsRaymond Horton-Smith Prize (1994)[2]
Scientific career
Fields
Institutions
Websiteocdem.ox.ac.uk/rajesh-thakker

Education

Thakker was educated at Pembroke College, Cambridge, where he was awarded his Master of Arts (MA), Bachelor of Medicine, Bachelor of Surgery (MB BChir), Doctor of Medicine (MD) and Doctor of Science (ScD) degrees. He completed his clinical training at Middlesex Hospital Medical School.[1]

Research and career

Thakker's research investigates neuroendocrine tumours such as multiple endocrine neoplasia type 1 (MEN1)[3][11][13][14] and the molecular basis of disorders of calcium homeostasis.[7] He has supervised nine successful Doctor of Philosophy students[15][16][17][18][19][20][21][22][23] and his research has been funded by the Medical Research Council (MRC).[24]

Thakker has edited several books including Genetic and Molecular Biological Aspects of Endocrine Disease,[25] Molecular Genetics of Endocrine Disorders,[26] and Genetics of Bone Biology and Skeletal Disease.[27]

Awards and honours

Thakker was elected a Fellow of the Royal Society (FRS) in 2014. His nomination reads:

Thakker has made a sustained series of major contributions to endocrinology, particularly parathyroid and renal disorders affecting calcium homeostasis. His research at the basic-science and clinical interface has resulted in seminal gene discoveries and insights into molecular, cellular and physiological mechanisms. These include: identification of functional pathways of calcium-sensing, through characterisation of mutations of the calcium-sensing-receptor, a G-protein-coupled- receptor (GPCR), and its signalling pathway through G-protein-alpha-11-subunit (Gα11) and adaptor-protein-2-sigma-subunit (AP2σ), which regulates GPCR endocytosis; and defining a molecular-based taxonomy of syndromic and non-syndromic hyperparathyroid and hypoparathyroid disorders that has resulted in new pathophysiological insights and advances in diagnosis and treatment.[28]

Personal life

Thakker is married to Julie Clare Magee and has one daughter, Clare Thakker, who has qualified as a doctor from Clare College, Cambridge.[1] He is a school governor at Oxford High School, Oxford.[29]

References
  1. Anon (2014). "Thakker, Prof. Rajesh Vasantlal". Who's Who (online edition via Oxford University Press ed.). A & C Black. doi:10.1093/ww/9780199540884.013.U37302. (Subscription or UK public library membership required.)
  2. ORCID 0000-0002-1438-3220
  3. "Professor Rajesh Thakker FRS FMedSci". acmedsci.ac.uk. Academy of Medical Sciences.
  4. Professor Rajesh Thakker, Somerville College, University of Oxford
  5. "EME Programme appoint new Chair of Funding Board". www.nihr.ac.uk. Archived from the original on 17 September 2016.
  6. Prof Rajesh V Thakker, Oxford Centre for Diabetes, Endocrinology and Metabolism OCDEM
  7. Rajesh Thakker publications indexed by the Scopus bibliographic database. (subscription required)
  8. Holmes, David (2013). "Rajesh Thakker: A man of hidden depths". The Lancet Diabetes & Endocrinology. 1 (4): 274. doi:10.1016/S2213-8587(13)70196-7. PMID 24622412.
  9. Lloyd, S. E.; Pearce, S. H.; Fisher, S. E.; Steinmeyer, K; Schwappach, B; Scheinman, S. J.; Harding, B; Bolino, A; Devoto, M; Goodyer, P; Rigden, S. P.; Wrong, O; Jentsch, T. J.; Craig, I. W.; Thakker, R. V. (1996). "A common molecular basis for three inherited kidney stone diseases". Nature. 379 (6564): 445–9. Bibcode:1996Natur.379..445L. doi:10.1038/379445a0. hdl:11858/00-001M-0000-0012-CBFE-2. PMID 8559248. S2CID 4364656.
  10. Modlin, I. M.; Oberg, K.; Chung, D. C.; Jensen, R. T.; De Herder, W. W.; Thakker, R. V.; Caplin, M.; Delle Fave, G.; Kaltsas, G. A.; Krenning, E. P.; Moss, S. F.; Nilsson, O.; Rindi, G.; Salazar, R.; Ruszniewski, P.; Sundin, A. (2008). "Gastroenteropancreatic neuroendocrine tumours". The Lancet Oncology. 9 (1): 61–72. doi:10.1016/S1470-2045(07)70410-2. PMID 18177818. S2CID 46127116.
  11. Pearce, S. H.; Williamson, C; Kifor, O; Bai, M; Coulthard, M. G.; Davies, M; Lewis-Barned, N; McCredie, D; Powell, H; Kendall-Taylor, P; Brown, E. M.; Thakker, R. V. (1996). "A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor". The New England Journal of Medicine. 335 (15): 1115–22. doi:10.1056/NEJM199610103351505. PMID 8813042.
  12. Carpten, J. D.; Robbins, C. M.; Villablanca, A; Forsberg, L; Presciuttini, S; Bailey-Wilson, J; Simonds, W. F.; Gillanders, E. M.; Kennedy, A. M.; Chen, J. D.; Agarwal, S. K.; Sood, R; Jones, M. P.; Moses, T. Y.; Haven, C; Petillo, D; Leotlela, P. D.; Harding, B; Cameron, D; Pannett, A. A.; Höög, A; Heath h, 3rd; James-Newton, L. A.; Robinson, B; Zarbo, R. J.; Cavaco, B. M.; Wassif, W; Perrier, N. D.; Rosen, I. B.; et al. (2002). "HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome". Nature Genetics. 32 (4): 676–80. doi:10.1038/ng1048. PMID 12434154. S2CID 23713328.
  13. Brandi, M. L.; Gagel, R. F.; Angeli, A; Bilezikian, J. P.; Beck-Peccoz, P; Bordi, C; Conte-Devolx, B; Falchetti, A; Gheri, R. G.; Libroia, A; Lips, C. J.; Lombardi, G; Mannelli, M; Pacini, F; Ponder, B. A.; Raue, F; Skogseid, B; Tamburrano, G; Thakker, R. V.; Thompson, N. W.; Tomassetti, P; Tonelli, F; Wells Jr, S. A.; Marx, S. J. (2001). "Guidelines for diagnosis and therapy of MEN type 1 and type 2". The Journal of Clinical Endocrinology and Metabolism. 86 (12): 5658–71. doi:10.1210/jcem.86.12.8070. PMID 11739416.
  14. Lemmens, I; Van De Ven, W. J.; Kas, K; Zhang, C. X.; Giraud, S; Wautot, V; Buisson, N; De Witte, K; Salandre, J; Lenoir, G; Pugeat, M; Calender, A; Parente, F; Quincey, D; Gaudray, P; De Wit, M. J.; Lips, C. J.; Höppener, J. W.; Khodaei, S; Grant, A. L.; Weber, G; Kytölä, S; Teh, B. T.; Farnebo, F; Thakker, R. V. (1997). "Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1". Human Molecular Genetics. 6 (7): 1177–83. doi:10.1093/hmg/6.7.1177. PMID 9215690.
  15. Bowl, Michael Richard (2003). Molecular genetics of hypoparathyroid disorders (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.275359.
  16. Bradley, Karin J. (2006). Molecular genetics of the hyperparathyroidism-jaw tumour syndrome (DPhil thesis). University of Oxford.
  17. Gaynor, Katherine Ursula (2011). The role of the transcription factor GATA3 in calcium homeostasis and tumourigenesis (DPhil thesis). University of Oxford.
  18. Leotlela, Poloko D. (2003). Molecular genetics of multiple endocrine neoplasia type 1 and related disorders (DPhil thesis). University of Oxford.
  19. Loureiro de Lemos, Manuel C. (2007). Genetic and phenotypic studies of the multiple endocrine neoplasia type 1 syndrome (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.445777.
  20. Javid, Mahsa (2012). Gene modifiers and novel therapies for multiple endocrine neoplasia type 1 (DPhil thesis). University of Oxford.
  21. Jeyabalan, Jeshmi (2008). Role of sedlin in spondyloepiphyseal dysplasia tarda (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.496979.
  22. Turner, Jeremy James Osborne (2003). Molecular genetics of renal tubular disorders affecting urate transport (DPhil thesis). University of Oxford.
  23. Wu, Fiona (2014). Dent's disease and the chloride channel, CLC-5 (DPhil thesis). University of Oxford.
  24. UK Government research grants awarded to Rajesh Thakker, via Research Councils UK
  25. Thakker, R. V (1995). Genetic and Molecular Biological Aspects of Endocrine Disease. ISBN 9780702019456.
  26. Thakker, R. (4 September 1998). Molecular Genetics of Endocrine Disorders. ISBN 9780412589706.
  27. Thakker, R. V; Whyte, Michael P; Eisman, John; Igarashi, Takashi (2013). Genetics of Bone Biology and Skeletal Disease. ISBN 9780123878298.
  28. "Professor Rajesh Thakker FMedSci FRS". London: The Royal Society. Archived from the original on 5 August 2014.
  29. "Oxford High School GDST School Governors". Archived from the original on 4 July 2014.
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