Pfiesteria

Pfiesteria is a genus of heterotrophic dinoflagellates that has been associated with harmful algal blooms and fish kills. Pfiesteria complex organisms (PCOs) were claimed to be responsible for large fish kills in the 1980s and 1990s on the coast of North Carolina and in tributaries of the Chesapeake Bay. In reaction to the toxic outbreaks, six states along the US east coast have initiated a monitoring program to allow for rapid response in the case of new outbreaks and to better understand the factors involved in Pfiesteria toxicity and outbreaks.[1] New molecular detection methods have revealed that Pfiesteria has a worldwide distribution.[2]

Pfiesteria
Scientific classification Edit this classification
Domain: Eukaryota
Clade: Diaphoretickes
Clade: SAR
Clade: Alveolata
Phylum: Myzozoa
Superclass: Dinoflagellata
Class: Dinophyceae
Order: Thoracosphaerales
Family: Pfiesteriaceae
Genus: Pfiesteria
Species

Pfiesteria piscicida
Pfiesteria shumwayae

Discovery and naming

Pfiesteria was discovered in 1988 by North Carolina State University researchers JoAnn Burkholder and Ed Noga. The genus was named after Lois Ann Pfiester (1936–1992), a biologist who did much of the early research on dinoflagellates.[3]

Species

There are two species described, Pfiesteria piscicida (from Latin Pisces, fish; cida, killer.[3]), which has a complex life cycle[4] and the species Pfiesteria shumwayae, also with a complex life cycle.[5] The type locality of Pfiesteria piscicida is Pamlico River Estuary, North Carolina, U.S.A.

Feeding strategy

Early research resulted in the hypothesis that Pfiesteria is a predatory dinoflagellate that acts as an ambush predator, utilizing a "hit and run" feeding strategy. Release of a toxin paralyzes the respiratory systems of susceptible fish, such as menhaden, causing death by suffocation. Pfiesteria then consumes the tissue sloughed off its dead prey.[6]

Controversy

Pfiesteria biology and the role of PCOs in killing fish and sickening humans have been subject to several controversies and conflicting research results over the last few years.[7][8]

  • Life cycle: Early research suggested a complex lifecycle of Pfiesteria piscicida, but this has become controversial over the past few years due to conflicting research results. Especially contested is the question of whether toxic amoeboid forms exist.[9]
  • Toxicity to fish: The hypothesis of Pfiesteria killing fish via releasing a toxin in the water has been questioned as no toxin could be isolated and no toxicity was observed in some experiments. Toxicity appears to depend on the strains and assays used.[10] The lesions observed on fish presumed killed by Pfiesteria have been attributed to water molds by some researchers. However, it has also been established that Pfiesteria shumwayae kills fish by feeding on their skin through myzocytosis.[11] In early 2007, a highly unstable toxin produced by the toxic form of Pfiesteria piscicida was identified.[12]
  • Human illness: The effects of PCOs on humans have been questioned, leading to the "Pfiesteria hysteria hypothesis." A critical review of this hypothesis in the late 1990s concluded that Pfiesteria-related illness was unlikely to be caused by mass hysteria.[13] Concluding that there was no evidence to support the existence of Pfiesteria-associated human illness, the National Institutes of Health discontinued funding for research into the effects of Pfiesteria toxin on humans shortly after a CDC sponsored Pfiesteria conference in 2000.[14] A subsequent evaluation, however, concluded that PCOs can cause human illness.[15] The controversy about the risk of Pfiesteria exposure to human health is still ongoing.[16][17]

In fiction
  • A fictional Pfiesteria species dangerous to humans featured in James Powlik's 1999 environmental thriller Sea Change.
  • The fictional species Pfiesteria homicida was one of the antagonists in Frank Schätzing's 2004 novel The Swarm. They are a biological weapon created by the yrr, the main antagonists of the novel.

References
  1. Magnien RE (2001). "State monitoring activities related to Pfiesteria-like organisms". Environ. Health Perspect. 109 (Suppl 5): 711–4. doi:10.2307/3454918. JSTOR 3454918. PMC 1240602. PMID 11677180.
  2. Rublee PA, Remington DL, Schaefer EF, Marshall MM (2005). "Detection of the Dinozoans Pfiesteria piscicida and P. shumwayae: a review of detection methods and geographic distribution" (PDF). J. Eukaryot. Microbiol. 52 (2): 83–9. doi:10.1111/j.1550-7408.2005.05202007.x. PMID 15817112. S2CID 15838304.
  3. Steidinger, K.A.; Burkholder, J.M.; Glasgow, H.B. Jr.; Hobbs, C.W.; Garrett, J.K.; Truby, E.W.; Noga, E.J.; Smith, S.A. (1996). "Pfiesteria piscicida gen. et sp. nov. (Pfiesteriaceae fam. nov.), a new toxic dinoflagellate with a complex life cycle and behavior". J. Phycol. 32: 157–164. doi:10.1111/j.0022-3646.1996.00157.x. S2CID 85246132.
  4. Parrow, M.W.; Burkholder, J.M. (2004). "The sexual life cycles of Pfiesteria piscicida and cryptoperidiniopsoids (dinophyceae)". J. Phycol. 40 (4): 664–673. doi:10.1111/j.1529-8817.2004.03202.x. S2CID 83695348.
  5. Parrow, M.W.; Burkholder, J.M. (2003). "Reproduction and sexuality in Pfiesteria shumwayae (Dinophyceae)". J. Phycol. 39 (4): 697–711. doi:10.1046/j.1529-8817.2003.03057.x. S2CID 86061227.
  6. Eichhorn, Susan E.; Raven, Peter H.; Evert, Ray Franklin (2005). Biology of plants. New York: W.H. Freeman and Company. pp. 205. ISBN 978-0-7167-1007-3.
  7. "Pfiesteria: Frequently Asked Questions". Archived from the original on 2007-09-28. Retrieved 2008-01-06.
  8. Miller TR, Belas R (2003). "Pfiesteria piscicida, P. shumwayae, and other Pfiesteria-like dinoflagellates". Res. Microbiol. 154 (2): 85–90. doi:10.1016/S0923-2508(03)00027-5. PMID 12648722.
  9. Peglar MT, Nerad TA, Anderson OR, Gillevet PM (2004). "Identification of amoebae implicated in the life cycle of Pfiesteria and Pfiesteria-like dinoflagellates". J. Eukaryot. Microbiol. 51 (5): 542–52. doi:10.1111/j.1550-7408.2004.tb00290.x. PMID 15537089. S2CID 43191086.
  10. Burkholder JM, Gordon AS, Moeller PD, et al. (2005). "Demonstration of toxicity to fish and to mammalian cells by Pfiesteria species: comparison of assay methods and strains". Proc. Natl. Acad. Sci. U.S.A. 102 (9): 3471–6. doi:10.1073/pnas.0500168102. PMC 552923. PMID 15728353.
  11. Vogelbein WK, Lovko VJ, Shields JD, et al. (2002). "Pfiesteria shumwayae kills fish by micropredation not exotoxin secretion". Nature. 418 (6901): 967–70. doi:10.1038/nature01008. PMID 12198545. S2CID 4388577.
  12. Moeller PD, Beauchesne KR, Huncik KM, Davis WC, Christopher SJ, Riggs-Gelasco P, Gelasco AK (2007). "Metal complexes and free radical toxins produced by Pfiesteria piscicida". Environ. Sci. Technol. 41 (4): 1166–72. doi:10.1021/es0617993. PMID 17598275.
  13. Greenberg DR, Tracy JK, Grattan LM (1998). "A critical review of the Pfiesteria hysteria hypothesis". Md Med J. 47 (3): 133–6. PMID 9601200.
  14. CDC National Conference on Pfiesteria: From Biology to Public Health October 18–20, 2000, Atlanta GA
  15. Collier DN, Burke WA (2002). "Pfiesteria complex organisms and human illness". South. Med. J. 95 (7): 720–6. doi:10.1097/00007611-200295070-00012. PMID 12144078. S2CID 38879446.
  16. Morris JG, Grattan LM, Wilson LA, et al. (2006). "Occupational exposure to pfiesteria species in estuarine waters is not a risk factor for illness". Environ. Health Perspect. 114 (7): 1038–43. doi:10.1289/ehp.8627. PMC 1513342. PMID 16835056.
  17. Shoemaker RC, Lawson W (2007). "Pfiesteria in estuarine waters: the question of health risks". Environ. Health Perspect. 115 (3): A126–7. doi:10.1289/ehp.115-a126. PMC 1849899. PMID 17431460.

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