Treasure Coast

• Port St. Lucie (principal city) pop. 217,523[7] C

• Fort Pierce pop. 43,601 C
• Sebastian pop. 23,344 C
• Stuart pop. 16,197 C
• Vero Beach pop. 16,017 C

• Fellsmere pop. 5,439 C
• Indiantown pop. 6,083 V

• Indian River Shores pop. 4,075 T
• Sewall's Point pop. 2,100 T

• St. Lucie Village pop. 604 T

• Palm City pop. 23,120
• Vero Beach South pop. 23,092
• Jensen Beach pop. 11,707
• Hobe Sound pop. 11,521
• Lakewood Park pop. 10,458
• Port Salerno pop. 10,091
• Gifford pop. 9,590
• Fort Pierce North pop. 6,474
• Indian River Estates pop. 6,220
• River Park pop. 5,222
• Fort Pierce South pop. 5,062
• White City pop. 3,719
• North River Shores pop. 3,101
• Roseland pop. 1,472

Vero Beach Regional Airport offers commercial passenger service on Breeze Airways. Other commercial airports nearby include Melbourne's Melbourne Orlando International Airport to the north (40 miles from Vero Beach), and West Palm Beach's Palm Beach International Airport to the south (30 miles from Hobe Sound). Other small regional airports in the area include Treasure Coast International Airport in Fort Pierce, and Witham Field in Stuart.

The Port of Fort Pierce, in Ft. Pierce, located along the Indian River across from the Fort Pierce Inlet, is one of Florida’s 14 deepwater ports and a locally significant port for imports and exports. The Intracoastal Waterway follows the Indian River as it passes through the Treasure Coast. The Okeechobee Waterway connects Stuart with Ft. Myers on the west coast, passing through Lake Okeechobee about halfway along the route.

Despite its large population, the Treasure Coast has only two major north–south highways running through the area: Florida's Turnpike (a toll road) and Interstate 95. In the southern half of the Treasure Coast, both routes run generally parallel to each other (twice crossing each other), but are mostly located along the extreme western edges of the cities lining the coast. North of Ft. Pierce, the turnpike leaves the Treasure Coast, heading northwest towards Orlando, leaving 95 as the only north-west highway in the northern half of the area.

Much closer to the coast, U.S. 1 is the only main north–south roadway passing through the cities. Along the western banks of the Indian River, and often on the barrier island for the region (Hutchinson Island and Orchid Island), is Florida State Road A1A.

Beginning in Stuart, Florida State Road 76 runs west out of Stuart, passing Indiantown around halfway through before ending at an intersection with U.S. 98/441 in Port Mayaca. Shortly after leaving Stuart, the road parallels the St. Lucie Canal along its southern edge until both terminate along the eastern shore of Lake Okeechobee.

Florida State Road 70 runs east-west, beginning in Ft. Pierce, passing through Okeechobee before terminating in Bradenton, 148 miles (238 km) from Ft. Pierce.

Florida State Road 60 connects Vero Beach in the east with Clearwater to the west, 161 miles (259 km) away.

The Florida East Coast Railway (FEC) operates freight service along the coast throughout the region. It also operates a rail yard just south of downtown Fort Pierce.

U.S. Sugar's South Central Florida Express, Inc. (SCXF) leases tracks between Pahokee and Fort Pierce from the FEC, known as the Lake Harbor Branch (K Branch). Along with trackage rights into FEC's Fort Pierce Yard, they also have a car haulage arrangement with FEC to Jacksonville to interchange with CSX and Norfolk Southern.

Up until 1963, long-distance passenger trains operated along the route. Among the most notable passenger trains were (main sponsors and destinations) the East Coast Champion (Atlantic Coast Line, New York City); City of Miami (Illinois Central, Chicago); Dixie Flyer (Louisville & Nashville, Chicago); Florida Special (winter season only; Florida East Coast Railway, New York City); Havana Special (Florida East Coast Railway, New York City); South Wind (Louisville & Nashville, Chicago).[8][9] The Southern Railway's Royal Palm from Cincinnati ended its service south of Jacksonville, along the Florida East Coast by 1958.[10]

Amtrak and the Florida Department of Transportation had been discussing returning passenger service to the coast.[11] In 2018, Brightline, an inter-city rail route that now currently runs between Miami and Orlando, announced that it was looking for sites for a new station between Fort Pierce and Miami.[12][13] As of September 2023, both Stuart and Fort Pierce are the candidates to receive the Brightline station.[14]