beta-Melanocyte-stimulating hormone

β-Melanocyte-stimulating hormone (β-MSH) is an endogenous peptide hormone and neuropeptide.[1] It is a melanocortin, specifically, one of the three types of melanocyte-stimulating hormone (MSH), and is produced from proopiomelanocortin (POMC).[1] It is an agonist of the MC1, MC3, MC4, and MC5 receptors.[1]

Beta-Melanocyte-stimulating hormone
Names
Other names
beta-MSH, β-melanotropin, β-melanocortin, β-intermedin
Identifiers
CAS Number
3D model (JSmol)
PubChem CID
SMILES
  • CC(C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NC(CC3=CNC=N3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC5=CNC6=CC=CC=C65)C(=O)NCC(=O)NC(CO)C(=O)N7CCCC7C(=O)N8CCCC8C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)O)N
Properties
Chemical formula
 C118H174N34O35S
Molar mass 2660.91596 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

B-melanocyte-stimulating hormone is artificially generated because it does not exist in humans naturally.[2]

β-MSH is also to decrease food intake in animals such as rats, chicken due to the effect of proopiomelanocortin (POMC).[3] Research was performed to see the effect β-MSH has on chicks, and it has been found that chicks responded with a decrease in food and water intake when treated with β-MSH. The experiment showed that β-MSH causes anorexigenic effects in chicks.[4]

See also

References
  1. Abba Kastin (26 January 2013). Handbook of Biologically Active Peptides. Academic Press. pp. 838–844. ISBN 978-0-12-385096-6.
  2. Bertagna, X; Lenne, F; Comar, D; Massias, J F; Wajcman, H; Baudin, V; Luton, J P; Girard, F (December 1986). "Human beta-melanocyte-stimulating hormone revisited". Proceedings of the National Academy of Sciences of the United States of America. 83 (24): 9719–9723. Bibcode:1986PNAS...83.9719B. doi:10.1073/pnas.83.24.9719. ISSN 0027-8424. PMC 387212. PMID 2432601.
  3. Kamisoyama, Hiroshi; Honda, Kazuhisa; Saneyasu, Takaoki; Sugahara, Kunio; Hasegawa, Shin (2009-07-24). "Corticotropin-releasing factor is a downstream mediator of the beta-melanocyte-stimulating hormone-induced anorexigenic pathway in chicks". Neuroscience Letters. 458 (3): 102–105. doi:10.1016/j.neulet.2009.04.041. ISSN 0304-3940. PMID 19393716. S2CID 42981014.
  4. Smith, M. L.; Prall, B.; Nandar, W.; Cline, M. A. (February 2008). "Beta-melanocyte-stimulating hormone potently reduces appetite via the hypothalamus in chicks". Journal of Neuroendocrinology. 20 (2): 220–226. doi:10.1111/j.1365-2826.2007.01639.x. ISSN 1365-2826. PMID 18088360. S2CID 19661927.


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