Allopurinol hypersensitivity syndrome
Allopurinol hypersensitivity syndrome typically occurs in persons with preexisting kidney failure.[1]: 119 Weeks to months after allopurinol is begun, the patient develops a morbilliform eruption[1]: 119 or, less commonly, develops one of the far more serious and potentially lethal severe cutaneous adverse reactions viz., the DRESS syndrome, Stevens Johnson syndrome, or toxic epidermal necrolysis.[2]
| Allopurinol hypersensitivity syndrome | |
|---|---|
 | |
| Allopurinol | |
| Symptoms | Fever, Cutaneous Reaction, Eosinophilia, Acute Renal Failure |
| Treatment | Systematic Corticosteroids |
| Frequency | Rare |
See also
References
- James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
- Wang CW, Dao RL, Chung WH (August 2016). "Immunopathogenesis and risk factors for allopurinol severe cutaneous adverse reactions". Current Opinion in Allergy and Clinical Immunology. 16 (4): 339–45. doi:10.1097/ACI.0000000000000286. PMID 27362322. S2CID 9183824.
External links
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