Bentracimab

Bentracimab is a monoclonal antibody medication which has been shown in phase one and two clinical trials to function as a reversal agent for the anti–blood clotting drug ticagrelor (which acts as a P2Y12 inhibitor and is sold under the brand name Brilinta among others).[2] It is under investigation for use in major, life-threatening bleeding in patients being treated with ticagrelor.[3][4] It is not commercially available.

Bentracimab
Monoclonal antibody
TypeFab fragment
SourceHuman
TargetTicagrelor, AR-C124910XX (the active metabolite)[1]
Clinical data
Other namesPB2452, MEDI2452
Routes of
administration		Intravenous infusion
ATC code
  • None
Legal status
Legal status
  • Investigational
Identifiers
CAS Number
PubChem SID
DrugBank
UNII
KEGG
Chemical and physical data
FormulaC2095H3240N560O674S12
Molar mass47440.93 g·mol−1

See also

References
  1. "Specialist Pharmacy Service: Bentracimab". National Health Service. 10 January 2021.
  2. "EU patients enrolled in REVERSE-IT trial of bentracimab for reversal of antiplatelet effects of ticagrelor". Cardiovascular News. 2021-01-29.
  3. Clinical trial number NCT04286438 for "A Phase 3, Multicenter, Open-Label, Single-Arm Study of Bentracimab (PB2452) in Ticagrelor-Treated Patients With Uncontrolled Major or Life-Threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure (REVERSE-IT Trial)" at ClinicalTrials.gov
  4. Makhdoum A, Dhingra NK, Kirubaharan A, Eikelboom R, Luc J, Dagher O, et al. (August 2021). "Ticagrelor use and practice patterns among Canadian cardiac surgeons". Journal of Cardiac Surgery. 36 (8): 2793–2801. doi:10.1111/jocs.15636. PMID 34028081.


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