C8 complex
Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC).
High Resolution Crystal Structure of Human Complement Component 8[1]
A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.
Membrane attack complex. Some labels are in Polish.
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Structure
C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.
References
- PDB: 3OJY; Lovelace LL, Cooper CL, Sodetz JM, Lebioda L (May 2011). "Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement". The Journal of Biological Chemistry. 286 (20): 17585–92. doi:10.1074/jbc.M111.219766. PMC 3093833. PMID 21454577.
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