Complement factor B

Complement factor B is a protein that in humans is encoded by the CFB gene.[5]

CFB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCFB, Cfb, AI195813, AI255840, Bf, C2, Fb, H2-Bf, AHUS4, ARMD14, BFD, CFAB, CFBD, FBI12, GBG, PBF2, complement factor B
External IDsOMIM: 138470 MGI: 105975 HomoloGene: 1292 GeneCards: CFB
Orthologs
SpeciesHumanMouse
Entrez

629

14962

Ensembl

ENSMUSG00000090231

UniProt

P00751

P04186

RefSeq (mRNA)

NM_001710

NM_001142706
NM_008198

RefSeq (protein)

NP_001701

NP_001136178
NP_032224
NP_001389804

Location (UCSC)Chr 6: 31.95 – 31.95 MbChr 17: 35.08 – 35.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC class III) region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.[5]

Alternative pathway. (Some labels are in Polish.)
Complement tests
C4 (C) FB (A) C3 CH50 Conditions
 · PSG, C3 NeF AA
 ·  · HAE, C4D
 ·  ·  · TCPD
 · /↓ SLE
inflammation

References

Further reading


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