Citiolone

Citiolone is a drug used in liver therapy.

Citiolone
Clinical data
ATC code
Identifiers
IUPAC name
  • (RS)-N-(2-Oxothiolan-3-yl)acetamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.013.449
Chemical and physical data
FormulaC6H9NO2S
Molar mass159.20 g·mol−1
InChI
  • InChI=1S/C6H9NO2S/c1-4(8)7-5-2-3-10-6(5)9/h5H,2-3H2,1H3,(H,7,8) Y
  • Key:NRFJZTXWLKPZAV-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

It is a derivative of the amino acid cysteine.[1] Citilone has also been studied with regards to hypothermia due to it being a hydroxyl free radical scavenger. The drug has been shown to protect hamster cells subjected to temperature conditions of 8-25 °C.[2]

References
  1. de Barrio M, Tornero P, Prieto A, Sainza T, Zubeldia JM, Herrero T (1997). "Recurrent fixed drug eruption caused by citiolone". Journal of Investigational Allergology & Clinical Immunology. 7 (3): 193–4. PMID 9252880.
  2. Kruuv, J.; Glofcheski, D.J. (1993). "Further Evidence for Two Modes of Hypothermia Damage". Cryobiology. 30 (3): 313–321. doi:10.1006/cryo.1993.1030. PMID 8370318.


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