Ornithine oxoglutarate

Ornithine oxoglutarate (OGO) or ornithine α-ketoglutarate (OKG) is a drug used in liver therapy. It is the salt formed from ornithine and alpha-ketoglutaric acid. It is also used to improve nutritional health in elderly patients.[1][2]

Ornithine oxoglutarate
Ornithine (top) and ketoglutaric acid (bottom)
Clinical data
ATC code
Identifiers
IUPAC name
  • 2-Oxopentanedioic acid - L-ornithine (1:1)
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
ECHA InfoCard100.047.261 100.023.615, 100.047.261
Chemical and physical data
FormulaC10H18N2O7
Molar mass278.261 g·mol−1
3D model (JSmol)
SMILES
  • C(C[C@@H](C(=O)O)N)CN.C(CC(=O)O)C(=O)C(=O)O
InChI
  • InChI=1S/C5H12N2O2.C5H6O5/c6-3-1-2-4(7)5(8)9;6-3(5(9)10)1-2-4(7)8/h4H,1-3,6-7H2,(H,8,9);1-2H2,(H,7,8)(H,9,10)/t4-;/m0./s1
  • Key:SLPUVFBNQHVEEU-WCCKRBBISA-N
  (verify)

References
  1. Blonde-Cynober F, Aussel C, Cynober L (January 2003). "Use of ornithine alpha-ketoglutarate in clinical nutrition of elderly patients". Nutrition. 19 (1): 73–5. doi:10.1016/S0899-9007(02)00849-3. PMID 12507647.
  2. Brocker P, Vellas B, Albarede JL, Poynard T (July 1994). "A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects". Age and Ageing. 23 (4): 303–6. doi:10.1093/ageing/23.4.303. PMID 7976777.
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