Debrisoquine

Debrisoquine is a derivative of guanidine. It is an antihypertensive drug similar to guanethidine. Debrisoquine is frequently used for phenotyping the CYP2D6 enzyme, a drug-metabolizing enzyme.[2]

Debrisoquine[1]
Names
Preferred IUPAC name
3,4-Dihydroisoquinoline-2(1H)-carboximidamide
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.013.155
KEGG
MeSH Debrisoquine
PubChem CID
UNII
InChI
  • InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12) Y
    Key: JWPGJSVJDAJRLW-UHFFFAOYSA-N Y
  • InChI=1/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12)
    Key: JWPGJSVJDAJRLW-UHFFFAOYAE
SMILES
  • [N@H]=C(N)N2Cc1c(cccc1)CC2
Properties
Chemical formula
 C10H13N3
Molar mass 175.23032
Pharmacology
C02CC04 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is YN ?)
Infobox references

See also
  • Isoquinoline#Applications of derivatives

The guanidine part of the molecule also appears in guanoxan and guanadrel.

  • The 7-bromo analog of Debrisoquine is called Guanisoquin.

References
  1. Debrisoquine – Compound Summary, PubChem.
  2. Fuhr, U.; Jetter, A.; Kirchheiner, J. (2007). "Appropriate Phenotyping Procedures for Drug Metabolizing Enzymes and Transporters in Humans and Their Simultaneous Use in the "Cocktail" Approach". Clinical Pharmacology & Therapeutics. 81 (2): 270–283. doi:10.1038/sj.clpt.6100050.


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