Effective renal plasma flow
Effective renal plasma flow (eRPF) is a measure used in renal physiology[1] to calculate renal plasma flow (RPF) and hence estimate renal function. The eRPF can be calculated with
| Parameter | Value |
|---|---|
| renal blood flow | RBF = 1000 mL/min |
| hematocrit | HCT = 40% |
| glomerular filtration rate | GFR = 120 mL/min |
| renal plasma flow | RPF = 600 mL/min |
| filtration fraction | FF = 20% |
| urine flow rate | V = 1 mL/min |
| Sodium | Inulin | Creatinine | PAH |
|---|---|---|---|
| SNa = 150 mEq/L | SIn = 1 mg/mL | SCr = 0.01 mg/mL | SPAH = |
| UNa = 710 mEq/L | UIn = 150 mg/mL | UCr = 1.25 mg/mL | UPAH = |
| CNa = 5 mL/min | CIn = 150 mL/min | CCr = 125 mL/min | CPAH = 420 mL/min |
| ER = 90% | |||
| ERPF = 540 mL/min |
where extraction ratio is the ratio of compound entering the kidney that is excreted into the final urine.[2]
When using a compound with an extraction ratio near 1, such as para-aminohippurate (PAH), eRPF approximates RPF. Therefore, PAH clearance can be used to estimate RPF.[3]
References
- "Hubio562: Clearance Lab Answers". Archived from the original on September 12, 2006. Retrieved 2009-04-29.
- Barrett, Kim E.; Brooks, Heddwen L.; Boitano, Scott; Barman, Susan M. (2010). Ganong's Review of Medical Physiology (23rd ed.). McGraw-Hill Medical. pp. 643–644. ISBN 978-0-07-160568-7. OCLC 430823856.
- Costanzo, Linda (2012). Physiology Cases and Problems. Lippincott Williams & Wilkins. p. 165. ISBN 9781451120615. Retrieved 1 November 2018.
External links
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