Renal chloride reabsorption

Renal reabsorption of chloride (Cl⁻) is a part of renal physiology, in order not to lose too much chloride in the urine.

Overview table

Characteristics of Cl⁻ reabsorption
Characteristic	proximal tubule			loop of Henle			Distal convoluted tubule	Collecting duct system
Characteristic	S1	S2	S3	descending limb	thin ascending limb	thick ascending limb	Distal convoluted tubule	connecting tubule	initial collecting tubule	cortical collecting ducts	medullary collecting ducts
reabsorption (%)
reabsorption (mmoles/day)
Concentration (mM)	115[1]		135[1]
electrical driving force (mV)	−3[2]		+3[2]			+15[2]	−5 to +5[2]			−40[2]
chemical driving force (mV)
electrochemical driving force (mV)	(positive) [3]
apical transport proteins	(passively)[3]		Cl-formate exchanger Cl-oxalate exchanger Cl⁻-OH⁻ exchanger			Na-K-2Cl cotransporter[1]	Na-Cl cotransporter[1]			principal cells: paracellularily[1]
basolateral transport proteins			chloride channels[1] Cl-K cotransporter[1] Cl⁻/HCO₃⁻ exchanger			chloride channels[1]	chloride channels[1]			chloride channels β intercalated cells: Cl⁻HCO₃⁻ exchanger[1]
Other reabsorption features

Walter F., PhD. Boron (2005). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 780
Walter F., PhD. Boron (2005). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 777
Walter F., PhD. Boron (2005). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 779

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