Epoetin beta

Epoetin beta (rINN) /ɛˈpoʊ.ɪtɪn/ is a synthetic, recombinant[2] form of erythropoietin, a protein that promotes the production of red blood cells. It is an erythropoiesis-stimulating agent (ESA) that is used to treat anemia, commonly associated with chronic kidney failure and cancer chemotherapy.

Epoetin beta
Clinical data
Trade namesNeoRecormon, Betapoietin, others[1]
AHFS/Drugs.comInternational Drug Names
License data
Routes of
administration		Intravenous, subcutaneous
ATC code
Legal status
Legal status
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
 NY (what is this?)  (verify)

Epoetin beta is sold under the brand name NeoRecormon, among others.[3] It is on the World Health Organization's List of Essential Medicines.[4]

Chemistry

Epoetin beta is a recombinant form of human erythropoietin which is produced in Chinese hamster ovary cells. It has the same protein sequence as natural human erythropoietin, being composed of 165 amino acids with about 30 KDa molecular weight.[5]

History

Erythropoietin (EPO) is a hormone produced in the kidneys. The existence of this hormone has been known since 1906, when scientists first started isolating it, and since the 1980s, a recombinant version of the hormone has been available for use in medical treatment.

See also

References
  1. Centers for Medicare and Medicaid Services: Erythrocyte Stimulating Agents. Accessed 15 February 2017.
  2. Dunn CJ, Markham A (February 1996). "Epoetin beta. A review of its pharmacological properties and clinical use in the management of anaemia associated with chronic renal failure". Drugs. 51 (2): 299–318. doi:10.2165/00003495-199651020-00008. PMID 8808169. S2CID 46985336.
  3. Amgen - Products. URL: http://www.amgen.com/patients/prca.html Archived 2007-10-28 at the Wayback Machine. Accessed 21 October 2007.
  4. World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  5. Medsafe: NeoRecormon Datasheet

Further reading
  • "Epoetin beta". Drug Information Portal. U.S. National Library of Medicine.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.