Ethambutol/isoniazid/pyrazinamide/rifampicin

Ethambutol/isoniazid/pyrazinamide/rifampicin
Combination of
Ethambutol	Anti-tuberculosis medication
Isoniazid	Anti-tuberculosis medication
Pyrazinamide	Anti-tuberculosis medication
Rifampicin	Anti-tuberculosis medication
Clinical data
Trade names	Voractiv, Rimstar, others
Routes of; administration	By mouth
ATC code	J04AM06 (WHO) ;
Identifiers
CAS Number	357397-87-6;
ChemSpider	none;

Ethambutol/isoniazid/pyrazinamide/rifampicin, also known as ethambutol/isoniazid/pyrazinamide/rifampin, is a medication used for tuberculosis.[1] It is a fixed dose combination of ethambutol, isoniazid, pyrazinamide, and rifampicin.[1] It is used either alone or with other antituberculosis medication.[1] It is taken by mouth.[1]

Side effects are those of the underlying medications.[1] Pyridoxine may be used to decrease the risk of numbness.[2] It is not recommended in people with liver problems or severe kidney problems.[3] Use may not be suitable in children.[1] It is unclear if use during pregnancy is safe.[3]

It is on the World Health Organization's List of Essential Medicines.[4] It is sold under the brand names Voractiv and Rimstar in the UK.[3]

References

World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 142. hdl:10665/44053. ISBN 9789241547659.
British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 403. ISBN 9780857111562.
"Rimstar Film-coated Tablet / Voractiv Film-coated Tablet - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. February 2016. Archived from the original on 20 December 2016. Retrieved 18 December 2016.
World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

External links

"Ethambutol mixture with Isoniazid". Drug Information Portal. U.S. National Library of Medicine.
"Isoniazid mixture with Rifampin". Drug Information Portal. U.S. National Library of Medicine.
"Pyrazinamide". Drug Information Portal. U.S. National Library of Medicine.

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[WHO2008-1] World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 142. hdl:10665/44053. ISBN 9789241547659.

[BNF69-2] British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 403. ISBN 9780857111562.

[UK2016-3] "Rimstar Film-coated Tablet / Voractiv Film-coated Tablet - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. February 2016. Archived from the original on 20 December 2016. Retrieved 18 December 2016.

[WHO21st-4] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.