Granuloma faciale

Granuloma faciale is an uncommon benign chronic skin disease of unknown origin characterized by single or multiple cutaneous nodules, usually occurring over the face.[1]^: 836 Occasionally, extrafacial involvement is noted, most often on sun-exposed areas.

Granuloma faciale
Other names	GF
Specialty	Dermatology

Diagnosis

Skin biopsy for histopathology: Focal LCV, diffuse dermal neutrophilia with leukocytoclasia, tissue eosinophilia & perivascular fibrosis.

Differential diagnosis

The disease mimics many other dermatoses and can be confused with conditions, such as sarcoidosis, discoid lupus erythematosus, mycosis fungoides, and fixed drug eruption.

Treatment

Topical corticosteroid, Intralesional corticosteroid, Dapsone, Colchicine, Antimalarial, Pulse dye laser, Carbon dioxide laser.

History

GF was first described in 1945 by John Edwin Mackonochie Wigley (1892–1962).[2]

References

James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.
Wigley, J. E. (1945). "Eosinophilic Granuloma. ? Sarcoid of Boeck". Proceedings of the Royal Society of Medicine. 38 (3): 125–126. PMC 2181658. PMID 19992999.

External links

Cutaneous keratosis, ulcer, atrophy, and necrobiosis

Epidermal thickening

Necrobiosis/granuloma

Necrobiotic/palisading	Granuloma annulare Perforating Generalized Subcutaneous Granuloma annulare in HIV disease Localized granuloma annulare Patch-type granuloma annulare Necrobiosis lipoidica Annular elastolytic giant-cell granuloma Granuloma multiforme Necrobiotic xanthogranuloma Palisaded neutrophilic and granulomatous dermatitis Rheumatoid nodulosis Interstitial granulomatous dermatitis/Interstitial granulomatous drug reaction
Foreign body granuloma	Beryllium granuloma Mercury granuloma Silica granuloma Silicone granuloma Zirconium granuloma Soot tattoo Tattoo Carbon stain
Other/ungrouped	eosinophilic dermatosis Granuloma faciale

Dermis/
localized CTD

Cutaneous lupus erythematosus	chronic: Discoid Panniculitis subacute: Neonatal ungrouped: Chilblain Lupus erythematosus–lichen planus overlap syndrome Tumid Verrucous Rowell's syndrome
Scleroderma/ Morphea	Localized scleroderma Localized morphea Morphea–lichen sclerosus et atrophicus overlap Generalized morphea Atrophoderma of Pasini and Pierini Pansclerotic morphea Morphea profunda Linear scleroderma
Atrophic/ atrophoderma	Lichen sclerosus Anetoderma Schweninger–Buzzi anetoderma Jadassohn–Pellizzari anetoderma Atrophoderma of Pasini and Pierini Acrodermatitis chronica atrophicans Semicircular lipoatrophy Follicular atrophoderma Linear atrophoderma of Moulin
Perforating	Kyrle disease Reactive perforating collagenosis Elastosis perforans serpiginosa Perforating folliculitis Acquired perforating dermatosis
Skin ulcer	Pyoderma gangrenosum
Other	Calcinosis cutis Sclerodactyly Poikiloderma vasculare atrophicans Ainhum/Pseudo-ainhum

Neutrophilic and eosinophilic dermatoses

Eosinophilic dermatosis

With vasculitis	Eosinophilic vasculitis Eosinophilic granulomatosis with polyangiitis
Without vasculitis	Arthropod assault Eosinophilic cellulitis Hypereosinophilic syndrome Papuloerythroderma of Ofuji Granuloma faciale Eosinophilic folliculitis
Ungrouped	Angiolymphoid hyperplasia with eosinophilia/Kimura's disease Annular erythema of infancy Eosinophilic fasciitis Eosinophilic granuloma Eosinophilic ulcer of the oral mucosa Erythema toxicum neonatorum Incontinentia pigmenti Itchy red bump disease Juvenile xanthogranuloma Pachydermatous eosinophilic dermatitis Papular eruption of blacks Pruritic papular eruption of HIV disease

Reactive neutrophilic dermatoses

Epidermis

Dermis

without vasculitis:	Sweet's syndrome Pyoderma gangrenosum Bowel-associated dermatosis–arthritis syndrome
with vasculitis:	Neutrophilic dermatosis of the dorsal hands

Ungrouped

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Classification	D ICD-10: L92.2 ICD-9-CM: 701.8 DiseasesDB: 33779
External resources	eMedicine: derm/170