Imidapril
Imidapril (trade name Tanatril) is an ACE inhibitor used as an antihypertensive drug and for the treatment of chronic heart failure.[1]
 | |
| Clinical data | |
|---|---|
| Trade names | Tanatril |
| AHFS/Drugs.com | UK Drug Information |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | 42% (imidaprilat) |
| Protein binding | 85% (imidapril), 53% (imidaprilat) |
| Metabolites | Imidaprilat (active metabolite) |
| Elimination half-life | 2 hrs (imidapril), 24 hrs (imidaprilat) |
| Excretion | 40% renal, 50% biliary |
| Identifiers | |
IUPAC name
| |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C20H27N3O6 |
| Molar mass | 405.451 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 139 to 140 °C (282 to 284 °F) |
SMILES
| |
InChI
| |
  (what is this?) (verify) | |
It was patented in 1982 and approved for medical use in 1993.[2]
Contraindications
Contraindications are hypersensitivity against ACE inhibitors, especially if it has resulted in angioedema; idiopathic or hereditary angioedema; kidney failure; the second and third trimesters in pregnancy; and combination with the drug aliskiren in people with diabetes.[3][4]
Adverse effects
Common adverse effects are similar to other antihypertensive drugs and include headache, vertigo, and drowsiness. A dry cough is common as with all ACE inhibitors.[3][4] Other possible adverse effects are described at ACE inhibitor#Adverse effects.
Interactions
No interaction studies have been conducted except with digoxin, which slightly decreases imidapril levels, possibly because it reduces its absorption from the gut. Other potential interactions are not well studied: Rifampicin reduces the activation of imidapril to its active metabolite imidaprilat. Like other ACE inhibitors, imidapril increases potassium levels in the blood and can therefore cause hyperkalaemia, especially when combined with potassium-sparing diuretics or potassium substitution. Other diuretics, vasodilators, tricyclic antidepressants and antipsychotics can add to the antihypertensive effect of imidapril. Lithium can reach toxic levels when combined with imidapril. The effect of antidiabetic drugs can be increased, potentially causing hypoglycaemia (low blood glucose levels).[3][4]
Pharmacology
Mechanism of action
Pharmacokinetics
About 70% of the ingested imidapril is absorbed quickly from the gut; this percentage is reduced significantly when taken with a fatty meal. It reaches highest blood plasma concentrations after two hours and has a biological half-life of two hours. The substance is a prodrug and is activated to imidaprilat, which reaches highest plasma concentrations after 7 hours, has an initial half-life of 7 to 9 hours and a terminal half-life of more than 24 hours. The absolute bioavailability of imidaprilat is 42%.[3][4]
About 40% of the drug is excreted via the urine and 50% via the bile and faeces.[3][4]
References
- Robinson DM, Curran MP, Lyseng-Williamson KA (2007). "Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure". Drugs. 67 (9): 1359–78. doi:10.2165/00003495-200767090-00008. PMID 17547476. S2CID 241327668.
- Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 469. ISBN 9783527607495.
- Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. 2019. Tanatril 10 mg-Tabletten.
- Dinnendahl V, Fricke U, eds. (2003). Arzneistoff-Profile (in German). Vol. 5 (18 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.