Lactic acid/citric acid/potassium bitartrate

Lactic acid/citric acid/potassium bitartrate, sold under the brand name Phexxi, is a non-hormonal combination medication used as a method of birth control.[1][2] It contains lactic acid, citric acid, and potassium bitartrate.[1][2] It is a gel inserted into the vagina.[2][3]

Lactic acid/citric acid/potassium bitartrate
Combination of
Lactic acidAlpha hydroxy acid
Citric acidTricarboxylic acid
Potassium bitartrateSugar acid salt
Clinical data
Trade namesPhexxi
AHFS/Drugs.comMultum Consumer Information
License data
Routes of
administration		Intravaginal
ATC code
  • None
Legal status
Legal status

The most common adverse reactions include vulvovaginal burning sensation, vulvovaginal pruritus, vulvovaginal mycotic infection, urinary tract infection, vulvovaginal discomfort, bacterial vaginosis, vaginal discharge, genital discomfort, dysuria, and vulvovaginal pain.[2]

Medical uses

The combination is indicated for the prevention of pregnancy in females of reproductive potential for use as an on-demand method of contraception.[2]

History

The combination was approved for medical use in the United States in May 2020.[2][4][5]

References
  1. "Phexxi- lactic acid, l-, citric acid monohydrate, and potassium bitartrate gel". DailyMed. Retrieved 13 February 2022.
  2. "U.S. FDA Approves Evofem Biosciences' Phexxi (lactic acid, citric acid and potassium bitartrate), the First and Only Non-Hormonal Prescription Gel for the Prevention of Pregnancy". Evofem Biosciences (Press release). 22 May 2020. Retrieved 22 May 2020 – via PR Newswire.
  3. Steinberg J, Lynch SE (May 2021). "Lactic Acid, Citric Acid, and Potassium Bitartrate (Phexxi) Vaginal Gel for Contraception". American Family Physician. 103 (10): 628–629. PMID 33982994.
  4. "Phexxi: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 23 May 2020.
  5. "Drug Approval Package: Phexxi". U.S. Food and Drug Administration (FDA). 3 November 2020. Retrieved 13 February 2022.


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