Secnidazole

Secnidazole (trade names Flagentyl, Sindose, Secnil, Solosec) is a nitroimidazole anti-infective. Effectiveness in the treatment of dientamoebiasis has been reported.[1] It has also been tested against Atopobium vaginae.[2]

Secnidazole
Clinical data
Trade namesSolosec
Other namesPM 185184, RP 14539
AHFS/Drugs.comInternational Drug Names
License data
Routes of
administration		Oral
ATC code
Legal status
Legal status
Identifiers
IUPAC name
  • 1-(2-Methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.020.123
Chemical and physical data
FormulaC7H11N3O3
Molar mass185.183 g·mol−1
3D model (JSmol)
SMILES
  • [O-][N+](=O)c1cnc(n1CC(O)C)C
InChI
  • InChI=1S/C7H11N3O3/c1-5(11)4-9-6(2)8-3-7(9)10(12)13/h3,5,11H,4H2,1-2H3 Y
  • Key:KPQZUUQMTUIKBP-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

In the United States, secnidazole is approved for the treatment of bacterial vaginosis and trichomoniasis in adult women.[3]

References
  1. Girginkardeşler N, Coşkun S, Cüneyt Balcioğlu I, Ertan P, Ok UZ (February 2003). "Dientamoeba fragilis, a neglected cause of diarrhea, successfully treated with secnidazole". Clinical Microbiology and Infection. 9 (2): 110–3. doi:10.1046/j.1469-0691.2003.00504.x. PMID 12588330.
  2. De Backer E, Dubreuil L, Brauman M, Acar J, Vaneechoutte M (May 2010). "In vitro activity of secnidazole against Atopobium vaginae, an anaerobic pathogen involved in bacterial vaginosis". Clinical Microbiology and Infection. 16 (5): 470–2. doi:10.1111/j.1469-0691.2009.02852.x. PMID 19548924.
  3. "FDA Approves Symbiomix Therapeutics' Solosec (secnidazole) Oral Granules for the Treatment of Bacterial Vaginosis in Adult Women" (Press release). Symbiomix Therapeutics.

Further reading
  • Gillis JC, Wiseman LR (April 1996). "Secnidazole. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis". Drugs. 51 (4): 621–38. doi:10.2165/00003495-199651040-00007. PMID 8706597.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.