Succinylsulfathiazole

Succinylsulfathiazole (also known as sulfasuxidine) is a sulfonamide. It is also spelled as succinylsulphathiazole. It is a white or yellow-white crystalline powder. It dissolves in aqueous solutions of alkali hydroxides and carbonates but is very slightly soluble in water.

Succinylsulfathiazole
Clinical data
ATC code
Identifiers
IUPAC name
  • 4-oxo-4-({4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}amino)butanoic acid
CAS Number
PubChem CID
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.003.765
Chemical and physical data
FormulaC13H13N3O5S2
Molar mass355.38 g·mol−1
3D model (JSmol)
SMILES
  • OC(=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2nccs2
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It is classified as ultra long acting drug. About 95% of the drug remains in the intestine and only 5% is hydrolyzed, slowly, to Sulfathiazole and is absorbed.

The drug is used for its antibacterial activity in the GIT. The dose is 10g - 20g daily in divided doses.

The Succinyl group is attached to form a Prodrug for Controlled release of drug Sulphathiazole.


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