Nitrofuran

Nitrofurans are a class of drugs typically used as antibiotics or antimicrobials.[1] The defining structural component is a furan ring with a nitro group.[2]

Nitrofural (nitrofurazone)

Drugs

Members of this class of drugs include:

  • Antibacterials (antibiotics)
  • Antimicrobials
    • Furaltadone — an antiprotozoal
    • Furazidine — an antibacterial and antiprotozoal
      • Furaginum — an antibacterial
    • Furylfuramide — a formerly used food preservative
    • Nifuratel — an antiprotozoal and antifungal
    • Nifurtimox — an antiprotozoal
  • FANFT, a potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria.

Regulation

The European Union has banned the use of Nitrofurans in food-producing animals. In the 2000s, a number of meat imports were destroyed after nitrofurans were found, including chicken imported from Portugal,[4] and chicken imported from Thailand and Brazil.[5]

References

  1. Chu, Pak-Sin; Lopez, Mayda I; Abraham, Ann; El Said, Kathleen R; Plakas, Steven M (2008). "Residue Depletion of Nitrofuran Drugs and Their Tissue-Bound Metabolites in Channel Catfish (Ictalurus punctatus) after Oral Dosing". Journal of Agricultural and Food Chemistry. 56 (17): 8030–8034. doi:10.1021/jf801398p. PMID 18698789.
  2. Vass, M; Hruska, K; Franek, M (2008). "Nitrofuran antibiotics: a review on the application, prohibition and residual analysis". Veterinarni Medicina. 53: 469–500. doi:10.17221/1979-VETMED.
  3. Huttner, Angela; Verhaegh, Els M; Harbarth, Stephan; Muller, Anouk E; Theuretzbacher, Ursula; Mouton, Johan W (2015). "Nitrofurantoin revisited: a systematic review and meta-analysis of controlled trials". Journal of Antimicrobial Chemotherapy. 70 (9): 2456–2464. doi:10.1093/jac/dkv147. PMID 26066581.
  4. "UK Food Law News (03-18)". www.reading.ac.uk.
  5. "UK Food Law News (02-35)". www.reading.ac.uk.
  • Nitrofurans at the US National Library of Medicine Medical Subject Headings (MeSH)
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