Transient hypogammaglobulinemia of infancy

Transient hypogammaglobulinemia of infancy is a form of hypogammaglobulinemia appearing after birth, leading to a reduction in the level of IgG, and also sometimes IgA[1][2] and IgM.[3] (The ratios of immunoglobulins vary rapidly in all infants, and the term dysgammaglobulinemia, although theoretically applicable, is not usually used in this context.)

Transient hypogammaglobulinemia of infancy
SpecialtyImmunology 

It can result in increased infections, but it can also present without symptoms.[4]

Pathophysiology

Normally, a newborn's immunoglobulins come from the mother during pregnancy and wane after birth until 3-6 months of age, when the infant begins to start to produce their own IgG. However, in transient hypogammaglobulinemia of infancy, the IgG synthesis is delayed, and the hypogammaglobulinemia is prolonged beyond age 6 months.[5]

See also

References
  1. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 818. ISBN 978-1-4160-2999-1.
  2. "Transient Hypogammaglobulinemia of Infancy: Immunodeficiency Disorders: Merck Manual Professional". Retrieved 2008-03-01.
  3. Kiliç SS, Tezcan I, Sanal O, Metin A, Ersoy F (2000). "Transient hypogammaglobulinemia of infancy: clinical and immunologic features of 40 new cases". Pediatr Int. 42 (6): 647–50. doi:10.1046/j.1442-200x.2000.01301.x. PMID 11192522. S2CID 25895833.
  4. Hsueh KC, Chiu HH, Lin HC, Hsu CH, Tsai FJ (2005). "Transient hypogammaglobulinemia of infancy presenting as Staphylococcus aureus sepsis with deep neck infection". J Microbiol Immunol Infect. 38 (2): 141–4. PMID 15843860.
  5. Justiz Vaillant, AA; Wilson, AM (January 2021). "Transient Hypogammaglobulinemia of Infancy". PMID 31335076. {{cite journal}}: Cite journal requires |journal= (help)


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