Urine

Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excreted from the body through the urethra.

Sample of human urine

Cellular metabolism generates many by-products that are rich in nitrogen and must be cleared from the bloodstream, such as urea, uric acid, and creatinine. These by-products are expelled from the body during urination, which is the primary method for excreting water-soluble chemicals from the body. A urinalysis can detect nitrogenous wastes of the mammalian body.

Urine plays an important role in the earth's nitrogen cycle. In balanced ecosystems, urine fertilizes the soil and thus helps plants to grow. Therefore, urine can be used as a fertilizer. Some animals use it to mark their territories. Historically, aged or fermented urine (known as lant) was also used for gunpowder production, household cleaning, tanning of leather and dyeing of textiles.

Human urine and feces are collectively referred to as human waste or human excreta, and are managed via sanitation systems. Livestock urine and feces also require proper management if the livestock population density is high.

Physiology
Main article: Renal physiology
The chemical structure of urea

Most animals have excretory systems for elimination of soluble toxic wastes. In humans, soluble wastes are excreted primarily by the urinary system and, to a lesser extent in terms of urea, removed by perspiration.[1] The urinary system consists of the kidneys, ureters, urinary bladder, and urethra. The system produces urine by a process of filtration, reabsorption, and tubular secretion. The kidneys extract the soluble wastes from the bloodstream, as well as excess water, sugars, and a variety of other compounds. The resulting urine contains high concentrations of urea and other substances, including toxins. Urine flows from the kidneys through the ureter, bladder, and finally the urethra before passing from the body.

Duration

Research looking at the duration of urination in a range of mammal species found that nine larger species urinated for 21 ± 13 seconds irrespective of body size.[2] Smaller species, including rodents and bats, cannot produce steady streams of urine and instead urinate with a series of drops.[2]

Characteristics

Quantity

Average urine production in adult humans is around 1.4 L of urine per person per day with a normal range of 0.6 to 2.6 L per person per day, produced in around 6 to 8 urinations per day depending on state of hydration, activity level, environmental factors, weight, and the individual's health.[3] Producing too much or too little urine needs medical attention. Polyuria is a condition of excessive production of urine (> 2.5 L/day), oliguria when < 400 mL are produced, and anuria being < 100 mL per day.

Constituents
Further information: Urinalysis
Urine under the microscope

About 91-96% of urine consists of water.[3] The remainder can be broadly characterized into inorganic salts, urea, organic compounds, and organic ammonium salts.[3][4] Urine also contains proteins, hormones, and a wide range of metabolites,[5] varying by what is introduced into the body.

The total solids in urine are on average 59 g per day per person.[5] Urea is the largest constituent of the solids, constituting more than 50% of the total. The daily volume and composition of urine varies per person based on the amount of physical exertion, environmental conditions, as well as water, salt, and protein intakes.[3] In healthy persons, urine contains very little protein and an excess is suggestive of illness, as with sugar.[5] Organic matter, in healthy persons, also is reported to at most 1.7 times more matter than minerals.[4] However, any more than that is suggestive of illness.[4]

Typical design values for the concentrations of constituents in fresh urine, based on data in Sweden and Switzerland[6]: 12 [7]
ParameterValue
pH6.2
Total nitrogen8830 mg/L
Ammonium/ammonia-N460 mg/L
Nitrate and nitrite0.06 mg/L
Chemical oxygen demand6000 mg/L
Total phosphorus800 – 2000 mg/L
Potassium2740 mg/L
Sulphate1500 mg/L
Sodium3450 mg/L
Magnesium120 mg/L
Chloride4970 mg/L
Calcium230 mg/L

However, it is important to note that lesser amounts and concentrations of other compounds and ions are often present in urination of humans.[5]

Color
See also: Abnormal urine color
Medical experts have long connected urine colour with certain medical conditions. A medieval chart showing the medical implications of different urine color

Urine varies in appearance, depending principally upon a body's level of hydration, interactions with drugs, compounds and pigments or dyes found in food, or diseases.[5] Normally, urine is a transparent solution ranging from colorless to amber, but is usually a pale yellow.[5] Usually urination color comes primarily from the presence of urobilin.[8] Urobilin is a final waste product resulting from the breakdown of heme from hemoglobin during the destruction of aging blood cells.

Colorless urine indicates over-hydration. Colorless urine in drug tests can suggest an attempt to avoid detection of illicit drugs in the bloodstream through over-hydration.

  • Dark yellow urine is often indicative of dehydration.
  • Yellowing may be caused by removal of excess riboflavin from the bloodstream.[9]
  • Certain medications such as rifampin and phenazopyridine can cause orange urine.
  • Bloody urine is termed hematuria, a symptom of a wide variety of medical conditions.
  • Dark orange to brown urine can be a symptom of jaundice, rhabdomyolysis, or Gilbert's syndrome.
  • Black or dark-colored urine is referred to as melanuria and may be caused by a melanoma or non-melanin acute intermittent porphyria.
  • Pinkish urine can result from the consumption of beets (beeturia)[5]
  • Greenish urine can result from the consumption of asparagus or foods, beverages with green pigments, or from a urinary tract infection.[5]
  • Reddish or brown urine may be caused by porphyria (not to be confused with the harmless,[5] temporary pink or reddish tint caused by beeturia).
  • Blue urine can be caused by the ingestion of methylene blue (e.g., in medications) or foods or beverages with blue dyes.
  • Blue urine stains can be caused by blue diaper syndrome.
  • Purple urine may be due to purple urine bag syndrome.
  • Dark urine due to low fluid intake.
  • Dark red urine due to blood (hematuria).
  • Dark red urine due to choluria.
  • Pinkish urine due to consumption of beetroots.
  • Green urine during long term infusion of the sedative propofol.

Odor

Sometime after leaving the body, urine may acquire a strong "fish-like" odor because of contamination with bacteria that break down urea into ammonia. This odor is not present in fresh urine of healthy individuals; its presence may be a sign of a urinary tract infection.

The odor of normal human urine can reflect what has been consumed or specific diseases.[5] For example, an individual with diabetes mellitus may present a sweetened urine odor. This can be due to kidney diseases as well, such as kidney stones. Additionally, the presence of amino acids in urine (diagnosed as maple syrup urine disease) can cause it to smell of maple syrup.[10]

Eating asparagus can cause a strong odor reminiscent of the vegetable caused by the body's breakdown of asparagusic acid.[11] Likewise consumption of saffron, alcohol, coffee, tuna fish, and onion can result in telltale scents.[12] Particularly spicy foods can have a similar effect, as their compounds pass through the kidneys without being fully broken down before exiting the body.[13][14]

pH

The pH normally is within the range of 5.5 to 7 with an average of 6.2.[3] In persons with hyperuricosuria, acidic urine can contribute to the formation of stones of uric acid in the kidneys, ureters, or bladder.[15] Urine pH can be monitored by a physician or at home.[16]

A diet which is high in protein from meat and dairy, as well as alcohol consumption can reduce urine pH, whilst potassium and organic acids, such as from diets high in fruit and vegetables, can increase the pH and make it more alkaline.[3]

Cranberries, popularly thought to decrease the pH of urine, have actually been shown not to acidify urine.[17] Drugs that can decrease urine pH include ammonium chloride, chlorothiazide diuretics, and methenamine mandelate.[18][19]

Density

Human urine has a specific gravity of 1.003–1.035.[3]

Bacteria and pathogens

Urine is not sterile, not even in the bladder.[20][21] In the urethra, epithelial cells lining the urethra are colonized by facultatively anaerobic Gram-negative rod and cocci bacteria.[22] One study conducted found total of 116 bacterial isolates were found in 77 healthy humans (ages 5–11) and 39 cows, a considerable amount being pathogens.[23] Pathogens identified and their percentages were:

Bacterial isolates in human urine and cows' [23]
Humans aged 5–11 Bacterial Percentage in Humans Bacterial Percentage in Cows
Bacillus 10.4% 5.1%
Staphylococcus 2.6% 2.6%
Citrobacter 3.9% 12.8%
Klebsiella 7.8% 12.8%
Escherichia coli 36.4% 23.1%
Proteus 18.2% 23.1%
Pseudomonas 9.1% 2.6%
Salmonella 3.9% 5.1%
Shigella 7.8% 12.8%

The study also states:

Multiple antibiotic resistance (MAR) rates recorded in children urinal bacterial species were 37.5-100% (Gram-positive) and 12.5-100% (Gram-negative), while MAR among the cow urinal bacteria was 12.5-75.0% (Gram-positive) and 25.0-100% (Gram-negative).

— Microbial evaluation and public health implications of urine as alternative therapy in clinical pediatric cases: health implication of urine therapy

Examination for medical purposes
A Doctor Examining Urine. Trophime Bigot.

Many physicians in ancient history resorted to the inspection and examination of the urine of their patients. Hermogenes wrote about the color and other attributes of urine as indicators of certain diseases. Abdul Malik Ibn Habib of Andalusia d.862 AD, mentions numerous reports of urine examination throughout the Umayyad empire.[24] Diabetes mellitus got its name because the urine is plentiful and sweet.[25] The name uroscopy refers to any visual examination of the urine,[26] including microscopy, although it often refers to the aforementioned prescientific or Proto-scientific forms of urine examination. Clinical urine tests today duly note the color, turbidity, and odor of urine but also include urinalysis, which chemically analyzes the urine and quantifies its constituents. A culture of the urine is performed when a urinary tract infection is suspected, as bacteriuria without symptoms doesn't require treatment.[27] A microscopic examination of the urine may be helpful to identify organic or inorganic substrates and help in the diagnosis.

The color and volume of urine can be reliable indicators of hydration level. Clear and copious urine is generally a sign of adequate hydration. Dark urine is a sign of dehydration. The exception occurs when diuretics are consumed, in which case urine can be clear and copious and the person still be dehydrated.

Uses
Urine of pregnant women in the first trimester is collected by a company which purifies the fertility hormone hCG from it (Ede, the Netherlands)

Source of medications

Urine contains proteins and other substances that are useful for medical therapy and are ingredients in many prescription drugs (e.g., Ureacin, Urecholine, Urowave). Urine from postmenopausal women is rich in gonadotropins that can yield follicle stimulating hormone and luteinizing hormone for fertility therapy.[28] One such commercial product is Pergonal.[29]

Urine from pregnant women contains enough human chorionic gonadotropins for commercial extraction and purification to produce hCG medication. Pregnant mare urine is the source of estrogens, namely Premarin.[28] Urine also contains antibodies, which can be used in diagnostic antibody tests for a range of pathogens, including HIV-1.[30]

Urine after four months of storage, ready to be used in gardening activities (note the colour and turbidity change compared to fresh human urine).
Fresh human urine after excretion

Urine can also be used to produce urokinase, which is used clinically as a thrombolytic agent.

Fertilizer
This section is an excerpt from Reuse of human excreta § Urine.[edit]

Urine contains large quantities of nitrogen (mostly as urea), as well as reasonable quantities of dissolved potassium.[31] The nutrient concentrations in urine vary with diet.[32] In particular, the nitrogen content in urine is related to quantity of protein in the diet: A high protein diet results in high urea levels in urine. The nitrogen content in urine is proportional to the total food protein in the person's diet, and the phosphorus content is proportional to the sum of total food protein and vegetal food protein.[33]: 5  Urine's eight main ionic species (> 0.1 meq L−1) are cations Na, K, NH4, Ca and the anions, Cl, SO4, PO4 and HCO3.[34] Urine typically contains 70% of the nitrogen and more than half the potassium found in sewage, while making up less than 1% of the overall volume.[31]

Typical design values for nutrients excreted with urine are: 4 kg nitrogen per person per year, 0.36 kg phosphorus per person per year and 1.0 kg potassium per person per year (these values were published as "proposed Swedish default values" in 2004).[33]: 5  The amount of urine produced by an adult is around 0.8 to 1.5 L per day.[35] Based on the quantity of 1.5 L urine per day (or 550 L per year), the concentration values of macronutrients as follows: 7.3 g/L N; .67 g/L P; 1.8 g/L K.[33]: 5 [36]: 11  These are design values but the actual values vary with diet.[31][lower-alpha 1] Urine's nutrient content, when expressed with the international fertilizer convention of N:P2O5:K2O, is approximately 7:1.5:2.2.[36][lower-alpha 2] Since urine is rather diluted as a fertilizer compared to dry manufactured nitrogen fertilizers such as di-ammonium-phosphate, the relative transport costs for urine are high as a lot of water needs to be transported.[36]

Applying urine as fertilizer has been called "closing the cycle of agricultural nutrient flows" or ecological sanitation or ecosan. Urine fertilizer is usually applied diluted with water because undiluted urine can chemically burn the leaves or roots of some plants, causing plant injury,[38] particularly if the soil moisture content is low. The dilution also helps to reduce odor development following application. When diluted with water (at a 1:5 ratio for container-grown annual crops with fresh growing medium each season or a 1:8 ratio for more general use), it can be applied directly to soil as a fertilizer.[39][40] The fertilization effect of urine has been found to be comparable to that of commercial nitrogen fertilizers.[41][42] Urine may contain pharmaceutical residues (environmental persistent pharmaceutical pollutants).[43] Concentrations of heavy metals such as lead, mercury, and cadmium, commonly found in sewage sludge, are much lower in urine.[44]

The general limitations to using urine as fertilizer depend mainly on the potential for buildup of excess nitrogen (due to the high ratio of that macronutrient),[39] and inorganic salts such as sodium chloride, which are also part of the wastes excreted by the renal system. Over-fertilization with urine or other nitrogen fertilizers can result in too much ammonia for plants to absorb, acidic conditions, or other phytotoxicity.[43] Important parameters to consider while fertilizing with urine include salinity tolerance of the plant, soil composition, addition of other fertilizing compounds, and quantity of rainfall or other irrigation.[32] It was reported in 1995 that urine nitrogen gaseous losses were relatively high and plant uptake lower than with labelled ammonium nitrate. In contrast, phosphorus was utilized at a higher rate than soluble phosphate.[34] Urine can also be used safely as a source of nitrogen in carbon-rich compost.[40]

Cleaning

Given that urea in urine breaks down into ammonia, urine has been used for cleaning. In pre-industrial times, urine was used – in the form of lant or aged urine – as a cleaning fluid.[45] Urine was also used for whitening teeth in Ancient Rome.[46]

Gunpowder

Urine was used before the development of a chemical industry in the manufacture of gunpowder. Urine, a nitrogen source, was used to moisten straw or other organic material, which was kept moist and allowed to rot for several months to over a year. The resulting salts were washed from the heap with water, which was evaporated to allow collection of crude saltpeter crystals, that were usually refined before being used in making gunpowder.[47]

Survival uses
See also: Urophagia

Urophagia is the consumption of urine. Urine was used in several ancient cultures for various health, healing, and cosmetic purposes; urine drinking is still practiced today. In extreme cases, people may drink urine if no other fluids are available, although numerous credible sources (including the US Army Field Manual) advise against using it. Urine is either consumed as a remedy to heal yourself or topically for external health. (Full article...)

The US Army Field Manual advises against drinking urine for survival. These guides explain that drinking urine tends to worsen rather than relieve dehydration due to the salts in it, and that urine should not be consumed in a survival situation, even when there is no other fluid available. In hot weather survival situations, where other sources of water are not available, soaking cloth (a shirt for example) in urine and putting it on the head can help cool the body.[48]

During World War I, Germans experimented with numerous poisonous gases as weapons. After the first German chlorine gas attacks, Allied troops were supplied with masks of cotton pads that had been soaked in urine. It was believed that the ammonia in the pad neutralized the chlorine. These pads were held over the face until the soldiers could escape from the poisonous fumes.

Urban legend states that urine works well against jellyfish stings.[49] This scenario has appeared many times in popular culture including in the Friends episode "The One With the Jellyfish", an early episode of Survivor, as well as the films The Real Cancun (2003), The Heartbreak Kid (2007) and The Paperboy (2012). However, at best it is ineffective, and in some cases this treatment may make the injury worse.[50][51][52]

Textiles

Urine has often been used as a mordant to help prepare textiles, especially wool, for dyeing. In the Scottish Highlands and Hebrides, the process of "waulking" (fulling) woven wool is preceded by soaking in urine, preferably infantile.[53]

Animal repellent

The urine of predator species is often used as a repellent against their prey species.[54] Urine plays a role in interspecific communication, since it contains semiochemicals that can act as kairomones.[55]

History
Medieval Welsh text from the Red Book of Hergest on uroscopy, called Ansoddau’r Trwnc (the Qualities of Urine). Opening lines (translated):
Since it is through the qualities of the urine that a person's faults and his dangers and his diseases and his illness can be identified...
Image of two facing pages of the illuminated manuscript of "Isagoge", fols. 42b and 43a. On the top of the left hand page is an illuminated letter "D" - initial of "De urinarum differencia negocium" (The matter of the differences of urines). Inside the letter is a picture of a master on bench pointing at a raised flask while lecturing on the "Book on urines" of Theophilus. The right hand page is only shown in part. On its very bottom is an illuminated letter "U" - initial of "Urina ergo est colamentum sanguinis" (Urine is the filtrate of the blood). Inside the letter is a picture of a master holding up a flask while explaining the diagnostic significance of urine to a student or a patient. HMD Collection, MS E 78.

The fermentation of urine by bacteria produces a solution of ammonia; hence fermented urine was used in Classical Antiquity to wash cloth and clothing, to remove hair from hides in preparation for tanning, to serve as a mordant in dying cloth, and to remove rust from iron.[56] Ancient Romans used fermented human urine (in the form of lant) to cleanse grease stains from clothing.[57] The emperor Nero instituted a tax (Latin: vectigal urinae) on the urine industry, continued by his successor, Vespasian. The Latin saying Pecunia non olet (money doesn't smell) is attributed to Vespasian – said to have been his reply to a complaint from his son about the unpleasant nature of the tax. Vespasian's name is still attached to public urinals in France (vespasiennes), Italy (vespasiani), and Romania (vespasiene).

Alchemists spent much time trying to extract gold from urine, which led to discoveries such as white phosphorus by German alchemist Hennig Brand when distilling fermented urine in 1669. In 1773 the French chemist Hilaire Rouelle discovered the organic compound urea by boiling urine dry.

Language

The English word urine (/ˈjuːrɪn/, /ˈjɜːrɪn/) comes from the Latin urina (-ae, f.), which is cognate with ancient words in various Indo-European languages that concern water, liquid, diving, rain, and urination (for example Sanskrit varṣati meaning "it rains" or vār meaning "water" and Greek ourein meaning "to urinate").[58] The onomatopoetic term piss predates the word urine however is now considered vulgar.[59][60] Urinate was at first used mostly in medical contexts. Piss is also used in such colloquialisms as to piss off,[59] piss poor, and the slang expression pissing down to mean heavy rain. Euphemisms and expressions used between parents and children (such as wee, pee, and many others) have long existed.

Lant is a word for aged urine, originating from the Old English word hland referring to urine in general.

See also

Notes
  2. For the amount of other elements in urine, see Rose 2015[31] and Rich Earth 2021.[37]

References
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    • Smith, William, A Dictionary of Greek and Roman Antiquities (London, England: John Murray, 1875), article: "Fullo" (i.e., fullers or launderers), pp. 551–553. Archived 2021-07-05 at the Wayback Machine
    • Rousset, Henri (31 March 1917) "The laundries of the Ancients," Archived 2021-07-05 at the Wayback Machine Scientific American Supplement, 83 (2152) : 197.
    • Bond, Sarah E., Trade and Taboo: Disreputable Professions in the Roman Mediterranean (Ann Arbor, Michigan: University of Michigan Press, 2016), p. 112. Archived 2021-07-05 at the Wayback Machine
    • Binz, Arthur (1936) "Altes und Neues über die technische Verwendung des Harnes" (Ancient and modern [information] about the technological use of urine), Zeitschrift für Angewandte Chemie, 49 (23) : 355–360. [in German]
    • Witty, Michael (December 2016) "Ancient Roman urine chemistry," Acta Archaeologica, 87 (1) : 179–191. Witty speculates that the Romans obtained ammonia in concentrated form by adding wood ash (impure potassium carbonate) to urine that had been fermented for several hours. Struvite (magnesium ammonium phosphate) is thereby precipitated, and the yield of struvite can be increased by then treating the solution with bittern, a magnesium-rich solution that is a byproduct of making salt from sea water. Roasting struvite releases ammonia vapors.
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