Guanabenz

Guanabenz
Clinical data
AHFS/Drugs.comConsumer Drug Information
MedlinePlusa686003
ATC code
  • none
Pharmacokinetic data
Protein binding90%
Elimination half-life6 hours
Identifiers
IUPAC name
  • 2-(2,6-dichlorobenzylidene)hydrazinecarboximidamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.023.410 Edit this at Wikidata
Chemical and physical data
FormulaC8H8Cl2N4
Molar mass231.08 g·mol−1
3D model (JSmol)
SMILES
  • Clc1cccc(Cl)c1\C=N\N=C(/N)N
InChI
  • InChI=1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+ checkY
  • Key:WDZVGELJXXEGPV-YIXHJXPBSA-N checkY
  (verify)

Guanabenz (pronounced GWAHN-a-benz, sold under the trade name Wytensin) is an alpha agonist of the alpha-2 adrenergic receptor that is used as an antihypertensive drug. It is used to treat high blood pressure (hypertension).[1][2]

The most common side effects during guanabenz therapy are dizziness, drowsiness, dry mouth, headache and weakness.

Guanabenz can make one drowsy or less alert, therefore driving or operating dangerous machinery is not recommended.

See also

References

  1. ↑ Walker BR, Hare LE, Deitch MW (1982). "Comparative antihypertensive effects of guanabenz and clonidine". The Journal of International Medical Research. 10 (1): 6–14. doi:10.1177/030006058201000102. PMID 7037502. S2CID 2139809.
  2. ↑ Bonham AC, Trapani AJ, Portis LR, Brody MJ (1984). "Studies on the mechanism of the central antihypertensive effect of guanabenz and clonidine". Journal of Hypertension Supplement. 2 (3): S543-6. PMID 6599714.


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