Eosinophilic granuloma

Humans

Lesion on a nose.

Human eosinophilic granuloma is characterized by abnormal proliferation of Langerhans cells (LCs). LCs are antigen-presenting cells derived from dendritic cells. In humans, eosinophilic granulomas are considered as a benign tumors that occurs mainly in children and adolescents. EG is a quite rare condition, and its incidence is higher in white than in black population, also slightly more affecting males than females. EG develops in 4-5 children (aged under 15) per million/year and in 1 or 2 adults per million/year.[1]

The etiology of EG is not fully understood yet. However, the onset of abnormal LC proliferation may be triggered by viral stimuli (EBV, Human Herpes virus 6), bacterial toxins or defective regulation of IL-1 and IL-10 production.[2] Another possible explanation may be a defect in Ras/MAPK signaling pathway due to mutation of signaling proteins. Particularly, it was published that about 50% of the EG cases had mutated BRAF V600 E gene[3] and about 21% displayed a mutation in MAP2K1.[4]

Signs and symptoms

Clinically, single or multiple lesions are present mostly on the axial skeleton - on the skull, spine, ribs, pelvis and long bones. Specifically, thoracic spine and frontal bone within the skull are the most affected in children. On the other hand, cervical spine and jaw bone are the major spots of EG lesions in adults. Symptoms of EG include stiffness, local pain, edema of surrounding tissues, posture change, and many others, depending on the affected bone.[1]

Lung EG is even less common. Its prevalence has not been published, however, lung EG was already diagnosed in approximately 5% of all lung biotic samples. Such condition may be asymptomatic, but also a non-productive cough, dyspnea, chest pain, fatigue, and spontaneous pneumothorax can occur.[1] Higher risk of lung EG is being associated with smoking.[5]

Diagnosis

Diagnostic options of EG comprise X-ray, CT and MR. Histopathological examination of the bioptic sample is focused on the presence of mononuclear LCs with prominent nuclear grooves (coffee bean shaped nuclei) with addition of eosinophils. Such examination also utilizes CD1 and CD207 (Langerin) staining.[6] Electron microscopy examination of the sample is based on detection of Birbeck granules, specific "tennis racquet" shaped inclusion within cytoplasm of LCs.[1]

Treatment

Single lesions spontaneously regress often, especially in children, thus are followed up in regular intervals. Patients suffering spinal lesions are immobilized to minimize the pain. More complicated cases with multiple lesions should be treated with corticosteroids, particularly with an intralesional injection of methylprednisolon. Corticosteroids also represent an option for pulmonary EG treatment.[1] Operative treatment includes bone grafting and surgical fixation. In advanced stages of the disease, lung transplantation may be required. High-risk patients with multiple lesions (CNS-risk bones, lungs) may undergo chemotherapy.[7]

Cats and Dogs

Lesion on the upper lip of a cat.

Feline EG

Feline eosinophilic granuloma complex (EGC) is relatively common condition, characterized by number of patterns affecting oral cavity, skin and mucocutaneous junctions of cats. EGC can be triggered by various stimuli, however, the feline allergic disease is the most relevant one. Among the others, insect bites (fleas), fungi infections and viruses (Feline leukemia virus, feline immunodeficiency virus) may be responsible.[8]

Three primary clinical lesions of EGC include indolent (also referred to as eosinophilic or rodent) ulcer, eosinophilic plaque and eosinophilic granuloma.[9]

Signs and symptoms

The lesions mostly appear on the upper lip as ulcers, but they also develop on the gums and palate. Other locations like foot pads are not exceptional and are typical for developing plaques instead of ulcers.[10] Such plaques may be itchy and swelling. In the case of oral ulceration, bleeding, pain and loss of appetite may be present.[11]

Treatment

The treatment of the EGC generally consists of hypoallergenic diet combined with insect bite prevention. Corticosteroids are administrated either orally or by long-acting intralesional injections. Alternatively, cyclosporine provides similar effect.[11]

Canine EG

Canine eosinophilic granuloma (CEG) is extremely rare autoinflammatory state affecting primarily oral cavity and surrounding areas of transition between mucosa and hairy skin. However, there has also been described forms affecting lungs or digits.[12] It may appear independently on the breed or age, although, particular breeds are more prone to the disease, such German shepherds, Labrador retrievers, Huskies and Cavalier King Charles spaniels. The disease also tends to appear mainly in dogs aged under 3 years.[13]

Eosinophilic granuloma lesions in dogs primarily consists of eosinophils with addition of various cell subtypes such macrophages, neutrophils, plasmocytes, lymphocytes, mast cells and many others.[13]

Signs and symptoms

CEG usually manifests as a plaque on the palate, gums, lips or tongue. These are proliferative white or reddish lesions that may be painful and can be the cause of halitosis and hemorrhage that are often present. Loss of appetite is the most obvious symptom indicating the illness. The lesions may spontaneously appear and wane.[14] Biopsy is usually required for conformation of the diagnosis.

Treatment

Although the etiology of the disease is not understood completely, it is believed that the most relevant triggers of the autoimmune reaction are various environmental stimuli, especially food allergens and insect bites. Thus, the treatment usually includes transition to hypoallergenic diet and protection from ectoparasites. Medication includes immunosuppressives (prednisone, azathioprine) either alone, or in combination with antibiotics or other drugs (cytostatics - chlorambucil). Remission of the lesions may occur in some cases, but in the others low doses of life-long immunosuppression may be necessary.[13] Recent publications mention electrochemotherapy as a novel therapeutical method of CEG providing selective disappearance of the granuloma mass.[14]

References

  1. 1 2 3 4 5 Jha, Suman K.; De Jesus, Orlando (2022), "Eosinophilic Granuloma", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 32644464, retrieved 2022-01-31
  2. ↑ Chadha, Manish; Agarwal, Anil; Agarwal, Nidhi; Singh, Manoj Kumar (June 2007). "Solitary eosinophilic granuloma of the radius. An unusual differential diagnosis". Acta Orthopaedica Belgica. 73 (3): 413–417. ISSN 0001-6462. PMID 17715738.
  3. ↑ Badalian-Very, Gayane; Vergilio, Jo-Anne; Degar, Barbara A.; MacConaill, Laura E.; Brandner, Barbara; Calicchio, Monica L.; Kuo, Frank C.; Ligon, Azra H.; Stevenson, Kristen E.; Kehoe, Sarah M.; Garraway, Levi A. (2010-09-16). "Recurrent BRAF mutations in Langerhans cell histiocytosis". Blood. 116 (11): 1919–1923. doi:10.1182/blood-2010-04-279083. ISSN 1528-0020. PMC 3173987. PMID 20519626.
  4. ↑ Tran, Gary; Huynh, Thy N.; Paller, Amy S. (March 2018). "Langerhans cell histiocytosis: A neoplastic disorder driven by Ras-ERK pathway mutations". Journal of the American Academy of Dermatology. 78 (3): 579–590.e4. doi:10.1016/j.jaad.2017.09.022. ISSN 1097-6787. PMID 29107340. S2CID 46767736.
  5. ↑ Ma, Jennifer; Laird, James H.; Chau, Karen W.; Chelius, Monica R.; Lok, Benjamin H.; Yahalom, Joachim (January 2019). "Langerhans cell histiocytosis in adults is associated with a high prevalence of hematologic and solid malignancies". Cancer Medicine. 8 (1): 58–66. doi:10.1002/cam4.1844. ISSN 2045-7634. PMC 6346231. PMID 30597769.
  6. ↑ Kumar, Neeta; Sayed, Shahin; Vinayak, Sudhir (2011-01-20). "Diagnosis of Langerhans cell histiocytosis on fine needle aspiration cytology: a case report and review of the cytology literature". Pathology Research International. 2011: 439518. doi:10.4061/2011/439518. ISSN 2042-003X. PMC 3034992. PMID 21331166.
  7. ↑ Kobayashi, Masayuki; Tojo, Arinobu (December 2018). "Langerhans cell histiocytosis in adults: Advances in pathophysiology and treatment". Cancer Science. 109 (12): 3707–3713. doi:10.1111/cas.13817. ISSN 1349-7006. PMC 6272080. PMID 30281871.
  8. ↑ Muse, Russell; Williamson, Nicola (2008-01-01), Morgan, Rhea V. (ed.), "CHAPTER 91 - Erosive and Ulcerative Diseases of the Skin", Handbook of Small Animal Practice (Fifth Edition), Saint Louis: W.B. Saunders, pp. 885–900, ISBN 978-1-4160-3949-5, retrieved 2022-01-31
  9. ↑ Hopke, Kaitlin P; Sargent, Sandra J (2019-12-16). "Novel presentation of eosinophilic granuloma complex in a cat". JFMS Open Reports. 5 (2): 2055116919891548. doi:10.1177/2055116919891548. ISSN 2055-1169. PMC 6918502. PMID 31897305.
  10. ↑ Hopke, Kaitlin P; Sargent, Sandra J (2019-12-16). "Novel presentation of eosinophilic granuloma complex in a cat". JFMS Open Reports. 5 (2): 2055116919891548. doi:10.1177/2055116919891548. ISSN 2055-1169. PMC 6918502. PMID 31897305.
  11. 1 2 "Feline Eosinophilic Granuloma Complex In Cats | VCA Animal Hospitals". vcahospitals.com. Retrieved 2022-01-31.
  12. ↑ Abbott, Dawn E. E.; Allen, Andrew L. (March 2020). "Canine eosinophilic pulmonary granulomatosis: case report and literature review". Journal of Veterinary Diagnostic Investigation. 32 (2): 329–335. doi:10.1177/1040638720907659. ISSN 1040-6387. PMC 7081515. PMID 32180541.
  13. 1 2 3 Mendelsohn, Danielle; Lewis, John R.; Scott, Kristin Iglesias; Brown, Dorothy C.; Reiter, Alexander M. (March 2019). "Clinicopathological Features, Risk Factors and Predispositions, and Response to Treatment of Eosinophilic Oral Disease in 24 Dogs (2000-2016)". Journal of Veterinary Dentistry. 36 (1): 25–31. doi:10.1177/0898756419834785. ISSN 0898-7564. PMID 31138045. S2CID 169032822.
  14. 1 2 Tellado, Matías Nicolás; Michinski, Sebastián Diego; Olaiz, Nahuel; Maglietti, Felipe; Marshall, Guillermo (2014-10-16). "Canine Oral Eosinophilic Granuloma Treated with Electrochemotherapy". Case Reports in Veterinary Medicine. 2014: e519197. doi:10.1155/2014/519197. ISSN 2090-7001.
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