Nedosiran
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Trade names | Rivfloza |
Other names | DCR-PHXC |
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Routes of administration | Subcutaneous |
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Nedosiran, sold under the brand name Rivfloza, is a medication used for the treatment of primary hyperoxaluria.[1] It is an LDHA-directed small interfering RNA developed by Dicerna Pharmaceuticals.[1][2]
Nedosiran was approved for medical use in the United States in September 2023.[1][3]
Medical uses
Nedosiran is indicated to lower urinary oxalate levels in people with primary hyperoxaluria type 1.[1]
References
- 1 2 3 4 5 "Rivfloza (nedosiran) injection, for subcutaneous use" (PDF). Archived (PDF) from the original on 1 October 2023. Retrieved 1 October 2023.
- ↑ "Nedosiran". Dicerna Pharmaceuticals. 17 August 2021. Archived from the original on 26 July 2023. Retrieved 1 October 2023.
- ↑ "Rivfloza: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 2 October 2023. Retrieved 1 October 2023.
Further reading
- Forbes TA, Brown BD, Lai C (June 2022). "Therapeutic RNA interference: A novel approach to the treatment of primary hyperoxaluria". British Journal of Clinical Pharmacology. 88 (6): 2525–2538. doi:10.1111/bcp.14925. PMC 9291495. PMID 34022071.
- Liu A, Zhao J, Shah M, Migliorati JM, Tawfik SM, Bahal R, et al. (November 2022). "Nedosiran, a Candidate siRNA Drug for the Treatment of Primary Hyperoxaluria: Design, Development, and Clinical Studies". ACS Pharmacology & Translational Science. 5 (11): 1007–1016. doi:10.1021/acsptsci.2c00110. PMC 9667536. PMID 36407951.
External links
- Clinical trial number NCT03847909 for "A Study to Evaluate DCR-PHXC in Children and Adults With Primary Hyperoxaluria Type 1 and Primary Hyperoxaluria Type 2 (PHYOX2)" at ClinicalTrials.gov
- Clinical trial number NCT04042402 for "Long Term Extension Study in Patients With Primary Hyperoxaluria (PHYOX3)" at ClinicalTrials.gov
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