Pemtumomab

Pemtumomab
Monoclonal antibody
Type?
SourceMouse
TargetMUC1
Clinical data
Trade namesTheragyn
Routes of
administration
Intraperitoneal
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
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Pemtumomab (trade name Theragyn) is a mouse monoclonal antibody used to treat cancer. The substance has affinity to various types of cancer, like ovarian cancer and peritoneal cancer, via the polymorphic epithelial mucin (PEM or MUC-1) and delivers the radioisotope Yttrium-90 into the tumour.[1] As of 2009, it is undergoing Phase III clinical trials.[2]

It has been granted orphan drug status in Europe.[3]

References

  1. Oei AL, Moreno M, Verheijen RH, Sweep FC, Thomas CM, Massuger LF, von Mensdorff-Pouilly S (October 2008). "Induction of IgG antibodies to MUC1 and survival in patients with epithelial ovarian cancer". International Journal of Cancer. 123 (8): 1848–53. doi:10.1002/ijc.23725. PMID 18661524. S2CID 2287723.
  2. Clinical trial number NCT00004115 for "Monoclonal Antibody Therapy in Treating Patients With Ovarian Cancer or Primary Peritoneal Cancer in Remission Following Surgery and Chemotherapy" at ClinicalTrials.gov
  3. Antisoma's Lead Product, Pemtumomab Granted European Orphan Drug Status
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