Social anxiety disorder

Not to be confused with Seasonal affective disorder.
Social anxiety disorder
Other names: Social phobia[1]
Facial expression of someone with anxiety
SpecialtyPsychiatry
SymptomsExcessive fear or anxiety in social situations due to the possibility of being judged[2][1]
ComplicationsDepression, substance misuse, suicide[2]
Usual onset8 to 15 years old[1]
DurationLong term[1]
TypesPerformance only[1]
Risk factorsGenetic and environmental factors[1]
Differential diagnosisShyness, agoraphobia, panic disorder, selective mutism, autism spectrum disorder[1]
TreatmentCognitive behavioral therapy, antidepressants, benzodiazapines, beta blockers[2]
Frequency7% per year (USA)[1][3]

Social anxiety disorder (SAD), also known as social phobia, is characterized by excessive fear or anxiety in social situations due to the possibility of being negatively judged by others.[2][1] Other symptoms may include speaking quietly and a low degree of eye contact.[2] Symptoms are to a degree that they impair functioning or significant distress occurs.[1] Complications may include depression, substance misuse, and thoughts of suicide.[2]

The cause involves a combination of genetic and environmental factors.[1] Those with affected family members are 2 to 6 times more likely to be affected.[1] Parenting that is overly controlling may be a risk.[2] It is a type of anxiety disorder.[1] Diagnosis requires ruling out other possible mental or physical disorders and for problems to persist for at least six month.[1] It is categorized as "performance only" if it only occurs during such events.[1]

Initial treatment is generally cognitive behavioral therapy (CBT), which may be done individually or in a group setting.[4] In those who decline CBT, medications in the SSRI class may be used.[4] Other medications may include beta blockers and benzodiazepines.[2] Without treatment, it may result in a decreased quality of life.[2]

About 7% of people are affected in a given year in the United States.[1][3] It is less common in other areas of the world, with rates of 2.3% in Europe.[1] Women are more commonly affected than men.[1] The typical age of onset is 8 to 15 years old.[1] The condition was first distinguished from agoraphobia in 1966.[2]

Signs and symptoms

Cognitive aspects

In cognitive models of social anxiety disorder, those with social phobias experience dread over how they will present to others. They may feel overly self-conscious, pay high self-attention after the activity, or have high performance standards for themselves. According to the social psychology theory of self-presentation, a sufferer attempts to create a well-mannered impression towards others but believe they are unable to do so. Many times, prior to the potentially anxiety-provoking social situation, sufferers may deliberately review what could go wrong and how to deal with each unexpected case. After the event, they may have the perception that they performed unsatisfactorily. Consequently, they will perceive anything that may have possibly been abnormal as embarrassing. These thoughts may extend for weeks or longer. Cognitive distortions are a hallmark and are learned about in CBT (cognitive-behavioral therapy). Thoughts are often self-defeating and inaccurate. Those with social phobia tend to interpret neutral or ambiguous conversations with a negative outlook and many studies suggest that socially anxious individuals remember more negative memories than those less distressed.[5]

An example of an instance may be that of an employee presenting to their co-workers. During the presentation, the person may stutter a word, upon which they may worry that other people significantly noticed and think that their perceptions of them as a presenter have been tarnished. This cognitive thought propels further anxiety which compounds with further stuttering, sweating, and, potentially, a panic attack.

Behavioural aspects

Social anxiety disorder is a persistent fear of one or more situations in which the person is exposed to possible scrutiny by others and fears that he or she may do something or act in a way that will be humiliating or embarrassing. It exceeds normal "shyness" as it leads to excessive social avoidance and substantial social or occupational impairment. Feared activities may include almost any type of social interaction, especially small groups, dating, parties, talking to strangers, restaurants, interviews, etc.

Those who suffer from social anxiety disorder fear being judged by others in society. In particular, individuals with social anxiety are nervous in the presence of people with authority and feel uncomfortable during physical examinations.[6] People who suffer from this disorder may behave a certain way or say something and then feel embarrassed or humiliated after. As a result, they often choose to isolate themselves from society to avoid such situations. They may also feel uncomfortable meeting people they do not know and act distant when they are with large groups of people. In some cases, they may show evidence of this disorder by avoiding eye contact, or blushing when someone is talking to them.[6][7]

According to psychologist B. F. Skinner, phobias are controlled by escape and avoidance behaviors. For instance, a student may leave the room when talking in front of the class (escape) and refrain from doing verbal presentations because of the previously encountered anxiety attack (avoid). Major avoidance behaviors could include an almost pathological or compulsive lying behavior in order to preserve self-image and avoid judgement in front of others. Minor avoidance behaviors are exposed when a person avoids eye contact and crosses his/her arms to avoid recognizable shaking.[5] A fight-or-flight response is then triggered in such events.

Physiological aspects

Physiological effects, similar to those in other anxiety disorders, are present in social phobias.[8] In adults, it may be tears as well as excessive sweating, nausea, difficulty breathing, shaking, and palpitations as a result of the fight-or-flight response. The walk disturbance (where a person is so worried about how they walk that they may lose balance) may appear, especially when passing a group of people. Blushing is commonly exhibited by individuals suffering from social phobia.[5] These visible symptoms further reinforce the anxiety in the presence of others. A 2006 study found that the area of the brain called the amygdala, part of the limbic system, is hyperactive when patients are shown threatening faces or confronted with frightening situations. They found that patients with more severe social phobia showed a correlation with the increased response in the amygdala.[9]

Social aspects

People with SAD avoid situations that most people consider "normal". They may have a hard time understanding how others can handle these situations so easily. People with SAD avoid all or most social situations and hide from others, which can affect their personal relationships. Social phobia can completely remove people from social situations due to the irrational fear of these situations. People with SAD may be addicted to social media networks, have sleep deprivation, and feel good when they avoid human interactions.[10] SAD can also lead to low self-esteem, negative thoughts, major depressive disorder, sensitivity to criticism, and poor social skills that don't improve.[11] People with SAD experience anxiety in a variety of social situations, from important, meaningful encounters, to everyday trivial ones. These people may feel more nervous in job interviews, dates, interactions with authority, or at work.[12]

Comorbidity

SAD shows a high degree of co-occurrence with other psychiatric disorders. In fact, a population-based study found that 66% of those with SAD had one or more additional mental health disorders.[13] SAD often occurs alongside low self-esteem and most commonly clinical depression, perhaps due to a lack of personal relationships and long periods of isolation related to social avoidance.[14] Clinical depression is 1.49 to 3.5 times more likely to occur in those with SAD.[14][15][16] Research also indicates that the presence of certain social fears (e.g., avoidance of participating in small groups, avoidance of going to a party) are more likely to trigger comorbid depressive symptoms than other social fears, and thus deserve a very careful audit during clinical assessment among patients with SAD.[17]

Anxiety disorders other than SAD are also very common in patients with SAD, in particular generalized anxiety disorder.[18][19] Avoidant personality disorder is likewise highly correlated with SAD, with comorbidity rates ranging from 25% to 89%.[14][20][21]

To try to reduce their anxiety and alleviate depression, people with social phobia may use alcohol or other drugs, which can lead to substance abuse. It is estimated that one-fifth of patients with social anxiety disorder also suffer from alcohol dependence.[22] However, some research suggests SAD is unrelated to, or even protective against alcohol-related problems.[23][24] Those who suffer from both alcoholism and social anxiety disorder are more likely to avoid group-based treatments and to relapse compared to people who do not have this combination.[25]

Causes

Research into the causes of social anxiety and social phobia is wide-ranging, encompassing multiple perspectives from neuroscience to sociology. Scientists have yet to pinpoint the exact causes. Studies suggest that genetics can play a part in combination with environmental factors. Social phobia is not caused by other mental disorders or substance abuse.[26] Generally, social anxiety begins at a specific point in an individual's life. This will develop over time as the person struggles to recover. Eventually, mild social awkwardness can develop into symptoms of social anxiety or phobia. Passive social media usage may cause social anxiety in some people.[27]

Genetics

It has been shown that there is a two to a threefold greater risk of having social phobia if a first-degree relative also has the disorder. This could be due to genetics and/or due to children acquiring social fears and avoidance through processes of observational learning or parental psychosocial education. Studies of identical twins brought up (via adoption) in different families have indicated that, if one twin developed social anxiety disorder, then the other was between 30 percent and 50 percent more likely than average to also develop the disorder.[28] To some extent, this "heritability" may not be specific – for example, studies have found that if a parent has any kind of anxiety disorder or clinical depression, then a child is somewhat more likely to develop an anxiety disorder or social phobia.[29] Studies suggest that parents of those with social anxiety disorder tend to be more socially isolated themselves (Bruch and Heimberg, 1994; Caster et al., 1999), and shyness in adoptive parents is significantly correlated with shyness in adopted children (Daniels and Plomin, 1985).

Growing up with overprotective and hypercritical parents has also been associated with social anxiety disorder.[6][30] Adolescents who were rated as having an insecure (anxious-ambivalent) attachment with their mother as infants were twice as likely to develop anxiety disorders by late adolescence, including social phobia.[31]

A related line of research has investigated 'behavioural inhibition' in infants – early signs of an inhibited and introspective or fearful nature. Studies have shown that around 10–15 percent of individuals show this early temperament, which appears to be partly due to genetics. Some continue to show this trait into adolescence and adulthood and appear to be more likely to develop social anxiety disorder.[32]

Social experiences

A previous negative social experience can be a trigger to social phobia,[33][34] perhaps particularly for individuals high in "interpersonal sensitivity". For around half of those diagnosed with social anxiety disorder, a specific traumatic or humiliating social event appears to be associated with the onset or worsening of the disorder;[35] this kind of event appears to be particularly related to specific social phobia, for example, regarding public speaking (Stemberg et al., 1995). As well as direct experiences, observing or hearing about the socially negative experiences of others (e.g. a faux pas committed by someone), or verbal warnings of social problems and dangers, may also make the development of a social anxiety disorder more likely.[36] Social anxiety disorder may be caused by the longer-term effects of not fitting in, or being bullied, rejected or ignored (Beidel and Turner, 1998). Shy adolescents or avoidant adults have emphasized unpleasant experiences with peers[37] or childhood bullying or harassment (Gilmartin, 1987). In one study, popularity was found to be negatively correlated with social anxiety, and children who were neglected by their peers reported higher social anxiety and fear of negative evaluation than other categories of children.[38] Socially phobic children appear less likely to receive positive reactions from peers,[39] and anxious or inhibited children may isolate themselves.[40]

Cultural influences

Cultural factors that have been related to social anxiety disorder include a society's attitude towards shyness and avoidance, affecting the ability to form relationships or access employment or education, and shame.[41] One study found that the effects of parenting are different depending on the culture: American children appear more likely to develop social anxiety disorder if their parents emphasize the importance of others' opinions and use shame as a disciplinary strategy (Leung et al., 1994), but this association was not found for Chinese/Chinese-American children. In China, research has indicated that shy-inhibited children are more accepted than their peers and more likely to be considered for leadership and considered competent, in contrast to the findings in Western countries.[42] Purely demographic variables may also play a role.

Problems in developing social skills, or 'social fluency', may be a cause of some social anxiety disorder, through either inability or lack of confidence to interact socially and gain positive reactions and acceptance from others. The studies have been mixed, however, with some studies not finding significant problems in social skills[43] while others have.[44] What does seem clear is that the socially anxious perceive their own social skills to be low.[45] It may be that the increasing need for sophisticated social skills in forming relationships or careers, and an emphasis on assertiveness and competitiveness, is making social anxiety problems more common, at least among the 'middle classes'.[46] An interpersonal or media emphasis on 'normal' or 'attractive' personal characteristics has also been argued to fuel perfectionism and feelings of inferiority or insecurity regarding negative evaluation from others. The need for social acceptance or social standing has been elaborated in other lines of research relating to social anxiety.[47]

Substance-induced

While alcohol initially relieves social phobia, excessive alcohol misuse can worsen social phobia symptoms and cause panic disorder to develop or worsen during alcohol intoxication and especially during alcohol withdrawal syndrome. This effect is not unique to alcohol but can also occur with long-term use of drugs that have a similar mechanism of action to alcohol such as the benzodiazepines which are sometimes prescribed as tranquillisers.[48] Benzodiazepines possess anti-anxiety properties and can be useful for the short-term treatment of severe anxiety. Like the anticonvulsants, they tend to be mild and well tolerated, although there is a risk of habit-forming. Benzodiazepines are usually administered orally for the treatment of anxiety; however, occasionally lorazepam or diazepam may be given intravenously for the treatment of panic attacks.[49]

The World Council of Anxiety does not recommend benzodiazepines for the long-term treatment of anxiety due to a range of problems associated with long-term use including tolerance, psychomotor impairment, cognitive and memory impairments, physical dependence and a benzodiazepine withdrawal syndrome upon discontinuation of benzodiazepines.[50] Despite increasing focus on the use of antidepressants and other agents for the treatment of anxiety, benzodiazepines have remained a mainstay of anxiolytic pharmacotherapy due to their robust efficacy, rapid onset of therapeutic effect, and generally favorable side effect profile.[51] Treatment patterns for psychotropic drugs appear to have remained stable over the past decade, with benzodiazepines being the most commonly used medication for panic disorder.[52]

Many people who are addicted to alcohol or prescribed benzodiazepines when it is explained to them they have a choice between ongoing ill mental health or quitting and recovering from their symptoms decide on quitting alcohol or their benzodiazepines.[53] Symptoms may temporarily worsen however, during alcohol withdrawal or benzodiazepine withdrawal.[53]

Psychological factors

Research has indicated the role of 'core' or 'unconditional' negative beliefs (e.g. "I am inept") and 'conditional' beliefs nearer to the surface (e.g. "If I show myself, I will be rejected"). They are thought to develop based on personality and adverse experiences and to be activated when the person feels under threat.[54] Recent research has also highlighted that conditional beliefs may also be at play (e.g., "If people see I'm anxious, they'll think that I'm weak").[55]

A secondary factor is self-concealment which involves concealing the expression of one's anxiety or its underlying beliefs.[56] One line of work has focused more specifically on the key role of self-presentational concerns.[57][58] The resulting anxiety states are seen as interfering with social performance and the ability to concentrate on interaction, which in turn creates more social problems, which strengthens the negative schema. Also highlighted has been a high focus on and worry about anxiety symptoms themselves and how they might appear to others.[59] A similar model[60] emphasizes the development of a distorted mental representation of the self and overestimates of the likelihood and consequences of negative evaluation, and of the performance standards that others have. Such cognitive-behavioral models consider the role of negatively biased memories of the past and the processes of rumination after an event, and fearful anticipation before it.

Studies have also highlighted the role of subtle avoidance and defensive factors, and shown how attempts to avoid feared negative evaluations or use of 'safety behaviors' (Clark & Wells, 1995) can make social interaction more difficult and the anxiety worse in the long run.[55] This work has been influential in the development of Cognitive Behavioral Therapy for social anxiety disorder, which has been shown to have efficacy.

Mechanisms

There are many studies investigating neural bases of social anxiety disorder.[61][62] Although the exact neural mechanisms have not been found yet, there is evidence relating social anxiety disorder to imbalance in some neurochemicals and hyperactivity in some brain areas.

Neurotransmitters

Sociability is closely tied to dopaminergic neurotransmission.[63] In a 2011 study, a direct relation between social status of volunteers and binding affinity of dopamine D2/3 receptors in the striatum was found.[64] Other research shows that the binding affinity of dopamine D2 receptors in the striatum of social anxiety sufferers is lower than in controls.[65] Some other research shows an abnormality in dopamine transporter density in the striatum of social anxiety sufferers.[66][67] However, some researchers have been unable to replicate previous findings of evidence of dopamine abnormality in social anxiety disorder.[68] Studies have shown high prevalence of social anxiety in Parkinson's disease and schizophrenia. In a recent study, social phobia was diagnosed in 50% of Parkinson's disease patients.[69] Other researchers have found social phobia symptoms in patients treated with dopamine antagonists like haloperidol, emphasizing the role of dopamine neurotransmission in social anxiety disorder.[70]

Some evidence points to the possibility that social anxiety disorder involves reduced serotonin receptor binding.[71] A recent study reports increased serotonin transporter binding in psychotropic medication-naive patients with generalized social anxiety disorder.[66] Although there is little evidence of abnormality in serotonin neurotransmission, the limited efficacy of medications which affect serotonin levels may indicate the role of this pathway. Paroxetine, sertraline and fluvoxamine are three SSRIs that have been approved by the FDA to treat social anxiety disorder. Some researchers believe that SSRIs decrease the activity of the amygdala.[61] There is also increasing focus on other candidate transmitters, e.g. norepinephrine and glutamate, which may be over-active in social anxiety disorder, and the inhibitory transmitter GABA, which may be under-active in the thalamus.[61][72]

Brain areas

The amygdala is part of the limbic system which is related to fear cognition and emotional learning. Individuals with social anxiety disorder have been found to have a hypersensitive amygdala; for example in relation to social threat cues (e.g. perceived negative evaluation by another person), angry or hostile faces, and while waiting to give a speech.[73] Recent research has also indicated that another area of the brain, the anterior cingulate cortex, which was already known to be involved in the experience of physical pain, also appears to be involved in the experience of 'social pain',[74] for example perceiving group exclusion.[75] Recent research also highlighted the potent role of the prefrontal cortex, especially its dorsolateral part, in the maintenance of cognitive biases involved in SAD.[76] A 2007 meta-analysis also found that individuals with social anxiety had hyperactivation in the amygdala and insula areas which are frequently associated with fear and negative emotional processing.[77]

Diagnosis

ICD-10 defines social phobia as a fear of scrutiny by other people leading to avoidance of social situations. The anxiety symptoms may present as a complaint of blushing, hand tremor, nausea or urgency of micturition. Symptoms may progress to panic attacks.[78]

Standardized rating scales such as the Social Phobia Inventory, the SPAI-B, Liebowitz Social Anxiety Scale, and the Social Interaction Anxiety Scale can be used to screen for social anxiety disorder and measure the severity of anxiety.[79][80][81][82][83]

DSM-V

DSM-5 defines Social Anxiety Disorder as a marked, or intense, fear or anxiety of social situations in which the individual may be scrutinized by others.[84]

Differential diagnosis

The DSM-IV criteria stated that an individual cannot receive a diagnosis of social anxiety disorder if their symptoms are better accounted for by one of the autism spectrum disorders such as autism and Asperger syndrome.[85]

Because of its close relationship and overlapping symptoms, treating people with social phobia may help understand the underlying connections to other mental disorders. Social anxiety disorder is often linked to bipolar disorder and attention deficit hyperactivity disorder (ADHD) and some believe that they share an underlying cyclothymic-anxious-sensitive disposition.[86][87] The co-occurrence of ADHD and social phobia is very high, especially when SCT symptoms are present.[88]

Prevention

Prevention of anxiety disorders is one focus of research.[89][90] Use of CBT and related techniques may decrease the number of children with social anxiety disorder following completion of prevention programs.[91]

Treatment

Counselling

The first-line treatment for social anxiety disorder is cognitive behavioral therapy (CBT) with medications such as selective serotonin reuptake inhibitors (SSRIs) used only in those who are not interested in therapy.[92]: 191 [4] Self-help based on principles of CBT is a second-line treatment.[92]: 191 [93][94]

There is some emerging evidence for the use of acceptance and commitment therapy (ACT) in the treatment of social anxiety disorder. ACT is considered an offshoot of traditional CBT and emphasizes accepting unpleasant symptoms rather than fighting against them, as well as psychological flexibility – the ability to adapt to changing situational demands, to shift one's perspective, and to balance competing desires.[95] ACT may be useful as a second line treatment for this disorder in situations where CBT is ineffective or refused.[96]

Some studies have suggested social skills training (SST) can help with social anxiety.[97][98] Examples of social skills focused on during SST for social anxiety disorder include: initiating conversations, establishing friendships, interacting with members of the preferred sex, constructing a speech and assertiveness skills.[99] However, it is not clear whether specific social skills techniques and training are required, rather than just support with general social functioning and exposure to social situations.[100]

Given the evidence that social anxiety disorder may predict subsequent development of other psychiatric disorders such as depression, early diagnosis and treatment is important.[15][16] Social anxiety disorder remains under-recognized in primary care practice, with patients often presenting for treatment only after the onset of complications such as clinical depression or substance abuse disorders.[101][102][103]

Medications

SSRIs

Selective serotonin reuptake inhibitors (SSRIs), a class of antidepressants, are the first choice of medication for generalized social phobia but a second line treatment.[92]: 191  Compared to older forms of medication, there is less risk of tolerability and drug dependency associated with SSRIs.[104]

Paroxetine and paroxetine CR, Sertraline, Escitalopram, Venlafaxine XR and Fluvoxamine CR (luvox CR) are all approved for SAD and are all effective for it especially paroxetine.[105] All SSRIs are somewhat effective for social anxiety except fluoxetine which was equivalent to placebo in all clinical trials except one.[106] Paroxetine was able to change personality and significantly increase extraversion.[107][108]

In a 1995 double-blind, placebo-controlled trial, the SSRI paroxetine was shown to result in clinically meaningful improvement in 55% of patients with generalized social anxiety disorder, compared with 23.9% of those taking placebo.[109] An October 2004 study yielded similar results. Patients were treated with either fluoxetine, psychotherapy, or a placebo. The first four sets saw improvement in 50.8 to 54.2 percent of the patients. Of those assigned to receive only a placebo, 31.7% achieved a rating of 1 or 2 on the Clinical Global Impression-Improvement scale. Those who sought both therapy and medication did not see a boost in improvement.[110] In double-blind, placebo-controlled trials other SSRIs like fluvoxamine, escitalopram and sertraline showed reduction of social anxiety symptoms, including anxiety, sensitivity to rejection and hostility.[111]

Citalopram also appears to be effective.[112]

General side-effects are common during the first weeks while the body adjusts to the drug. Symptoms may include headaches, nausea, insomnia and changes in sexual behavior. Treatment safety during pregnancy has not been established.[113] In late 2004 much media attention was given to a proposed link between SSRI use and suicidality [a term that encompasses suicidal ideation and attempts at suicide as well as suicide]. For this reason, [although evidential causality between SSRI use and actual suicide has not been demonstrated] the use of SSRIs in pediatric cases of depression is now recognized by the Food and Drug Administration as warranting a cautionary statement to the parents of children who may be prescribed SSRIs by a family doctor.[114] Recent studies have shown no increase in rates of suicide.[115] These tests, however, represent those diagnosed with depression, not necessarily with social anxiety disorder.

In addition, studies show that more socially phobic patients treated with anti-depressant medication develop hypomania than non-phobic controls. The hypomania can be seen as the medication creating a new problem.[116][117]

Others

Other prescription drugs are also used, if other methods are not effective. Before the introduction of SSRIs, monoamine oxidase inhibitors (MAOIs) such as phenelzine were frequently used in the treatment of social anxiety.[118] Evidence continues to indicate that MAOIs are effective in the treatment and management of social anxiety disorder and they are still used, but generally only as a last resort medication, owing to concerns about dietary restrictions, possible adverse drug interactions and a recommendation of multiple doses per day.[119] A newer type of this medication, reversible inhibitors of monoamine oxidase subtype A (RIMAs) such as the drug moclobemide, bind reversibly to the MAO-A enzyme, greatly reducing the risk of hypertensive crisis with dietary tyramine intake.[120]

Benzodiazepines are an alternative to SSRIs. These drugs recommended usage is for short-term relief, meaning a limited time frame of over a year, of severe, disabling anxiety.[121] Although benzodiazepines are still sometimes prescribed for long-term everyday use in some countries, there is concern over the development of drug tolerance, dependency and misuse. It has been recommended that benzodiazepines be considered only for individuals who fail to respond to other medications.[122] Benzodiazepines augment the action of GABA, the major inhibitory neurotransmitter in the brain; effects usually begin to appear within minutes or hours. In most patients, tolerance rapidly develops to the sedative effects of benzodiazepines, but not to the anxiolytic effects. Long-term use of benzodiazepine may result in physical dependence, and abrupt discontinuation of the drug should be avoided due to high potential for withdrawal symptoms (including tremor, insomnia, and in rare cases, seizures). A gradual tapering of the dose of clonazepam (a decrease of 0.25 mg every 2 weeks), however, has been shown to be well tolerated by patients with social anxiety disorder. Benzodiazepines are not recommended as monotherapy for patients who have major depression in addition to social anxiety disorder and should be avoided in patients with a history of substance abuse.[6]

Certain anticonvulsant drugs such as gabapentin are effective in social anxiety disorder and may be a possible treatment alternative to benzodiazepines.[123][124]

Serotonin-norepinephrine reuptake inhibitors (SNRIs) such as venlafaxine[125][126][127] have shown similar effectiveness to the SSRIs. In Japan, Milnacipran is used in the treatment of Taijin kyofusho, a Japanese variant of social anxiety disorder.[128] The atypical antidepressants mirtazapine and bupropion have been studied for the treatment of social anxiety disorder, and rendered mixed results.[129][130][131]

Some people with a form of social phobia called performance phobia have been helped by beta-blockers, which are more commonly used to control high blood pressure. Taken in low doses, they control the physical manifestation of anxiety and can be taken before a public performance.

A novel treatment approach has recently been developed as a result of translational research. It has been shown that a combination of acute dosing of d-cycloserine (DCS) with exposure therapy facilitates the effects of exposure therapy of social phobia.[132] DCS is an old antibiotic medication used for treating tuberculosis and does not have any anxiolytic properties per se. However, it acts as an agonist at the glutamatergic N-methyl-D-aspartate (NMDA) receptor site, which is important for learning and memory.[133]

Kava-kava has also attracted attention as a possible treatment,[134] although safety concerns exist.[135][136]

Epidemiology

Country Prevalence
United States 2–7%[137]
England 0.4% (children)[138]
Scotland 1.8% (children)[138]
Wales 0.6% (children)[138]
Australia 1–2.7%[139]
Brazil 4.7–7.9%[140]
India 12.8% (adolescents)[141]
Iran 0.8%[142]
Israel 4.5%[143]
Nigeria 9.4% (university)[144]
Sweden 15.6%[145]
Turkey 9.6% (university)[146]
Poland 7–9% (2002)[147]
Taiwan 7% children (2002~08)[148]

Social anxiety disorder is known to appear at an early age in most cases. Fifty percent of those who develop this disorder have developed it by the age of 11, and 80% have developed it by age 20.[149] This early age of onset may lead to people with social anxiety disorder being particularly vulnerable to depressive illnesses, drug abuse and other psychological conflicts.[150]

When prevalence estimates were based on the examination of psychiatric clinic samples, social anxiety disorder was thought to be a relatively rare disorder. The opposite was found to be true; social anxiety was common, but many were afraid to seek psychiatric help, leading to an underrecognition of the problem.[5]

The National Comorbidity Survey of over 8,000 American correspondents in 1994 revealed 12-month and lifetime prevalence rates of 7.9 percent and 13.3 percent, respectively; this makes it the third most prevalent psychiatric disorder after depression and alcohol dependence, and the most common of the anxiety disorders.[151] According to US epidemiological data from the National Institute of Mental Health, social phobia affects 15 million adult Americans in any given year.[152] Estimates vary within 2 percent and 7 percent of the U.S. adult population.[153]

The mean onset of social phobia is 10 to 13 years.[154] Onset after age 25 is rare and is typically preceded by panic disorder or major depression.[155] Social anxiety disorder occurs more often in females than males.[156] The prevalence of social phobia appears to be increasing among white, married, and well-educated individuals. As a group, those with generalized social phobia are less likely to graduate from high school and are more likely to rely on government financial assistance or have poverty-level salaries.[157] Surveys carried out in 2002 show the youth of England, Scotland, and Wales have a prevalence rate of 0.4 percent, 1.8 percent, and 0.6 percent, respectively.[158] In Canada, the prevalence of self-reported social anxiety for Nova Scotians older than 14 years was 4.2 percent in June 2004 with women (4.6 percent) reporting more than men (3.8 percent).[159] In Australia, social phobia is the 8th and 5th leading disease or illness for males and females between 15 and 24 years of age as of 2003.[160] Because of the difficulty in separating social phobia from poor social skills or shyness, some studies have a large range of prevalence.[161] The table also shows higher prevalence in Sweden.

History

Literary descriptions of shyness can be traced back to the days of Hippocrates around 400 B.C. Hippocrates described someone who "through bashfulness, suspicion, and timorousness, will not be seen abroad; loves darkness as life and cannot endure the light or to sit in lightsome places; his hat still in his eyes, he will neither see, nor be seen by his good will. He dare not come in company for fear he should be misused, disgraced, overshoot himself in gesture or speeches, or be sick; he thinks every man observes him."[162]

The first mention of the psychiatric term "social phobia" (phobie des situations sociales) was made in the early 1900s.[163] Psychologists used the term "social neurosis" to describe extremely shy patients in the 1930s. After extensive work by Joseph Wolpe on systematic desensitization, research on phobias and their treatment grew. The idea that social phobia was a separate entity from other phobias came from the British psychiatrist Isaac Marks in the 1960s. This was accepted by the American Psychiatric Association and was first officially included in the third edition of the Diagnostic and Statistical Manual of Mental Disorders. The definition of the phobia was revised in 1989 to allow comorbidity with avoidant personality disorder and introduced generalized social phobia.[5] Social phobia had been largely ignored prior to 1985.[164]

After a call to action by psychiatrist Michael Liebowitz and clinical psychologist Richard Heimberg, there was an increase in attention to and research on the disorder. The DSM-IV gave social phobia the alternative name "social anxiety disorder". Research on the psychology and sociology of everyday social anxiety continued. Cognitive Behavioural models and therapies were developed for social anxiety disorder. In the 1990s, paroxetine became the first prescription drug in the U.S. approved to treat social anxiety disorder, with others following.

Terminology

It has also been referred to as anthropophobia,[165][166] meaning "fear of humans", from Greek: άνθρωπος, ánthropos, "human" and φόβος, phóbos, "fear". Other names have included interpersonal relation phobia.[165] A specific Japanese cultural form is known as taijin kyofusho.[128]

See also

References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 Diagnostic and Statistical Manual of Mental Disorders (Fifth ed.). American Psychiatric Association. 2013. pp. 202-208. doi:10.1176/appi.books.9780890425596.156852. ISBN 978-0-89042-555-8. {{cite book}}: Cite has empty unknown parameter: |1= (help)
  2. 1 2 3 4 5 6 7 8 9 10 Rose, GM; Tadi, P (January 2020). "Social Anxiety Disorder". PMID 32310350. {{cite journal}}: Cite journal requires |journal= (help)
  3. 1 2 "NIMH » Social Anxiety Disorder". www.nimh.nih.gov. Archived from the original on 22 January 2018. Retrieved 11 January 2021.
  4. 1 2 3 Pilling, S; Mayo-Wilson, E; Mavranezouli, I; Kew, K; Taylor, C; Clark, DM; Guideline Development, Group (May 22, 2013). "Recognition, assessment and treatment of social anxiety disorder: summary of NICE guidance" (PDF). BMJ (Clinical Research Ed.). 346: f2541. doi:10.1136/bmj.f2541. PMID 23697669. S2CID 13776769. Archived (PDF) from the original on February 24, 2021. Retrieved January 3, 2021.
  5. 1 2 3 4 5 Furmark, Thomas. Social Phobia – From Epidemiology to Brain Function Archived 2009-03-27 at the Wayback Machine. Retrieved February 21, 2006.
  6. 1 2 3 4 Schneier, Franklin (7 September 2006). "Social Anxiety Disorder". The New England Journal of Medicine. 355 (10): 1029–1036. doi:10.1056/nejmcp060145. PMID 16957148.
  7. ↑ Stein, Murray. "Murray". council of University libraries. {{cite web}}: Missing or empty |url= (help)
  8. ↑ eNotes. Social phobia – Causes Archived 2006-02-09 at the Wayback Machine. Retrieved February 22, 2006.
  9. ↑ Studying Brain Activity Could Aid Diagnosis Of Social Phobia Archived 2017-08-25 at the Wayback Machine. Monash University. January 19, 2006.
  10. ↑ Dobrean, Anca; Păsărelu, Costina-Ruxandra (2016-12-07). "Impact of Social Media on Social Anxiety: A Systematic Review". New Developments in Anxiety Disorders. doi:10.5772/65188. ISBN 978-953-51-2791-8. Archived from the original on 2021-01-26. Retrieved 2021-01-03.
  11. ↑ "How does social anxiety disorder affect my life?". WebMD. Archived from the original on 2020-09-19. Retrieved 2020-09-30.
  12. ↑ M. Kowalski, R. Leary, Mark and Robin (1995). Social Anxiety. London and New York: The Guilford Press.
  13. ↑ Acarturk, C.; De Graaf, R.; Van Straten, A.; Have, M. T.; Cuijpers, P. (2008). "Social phobia and number of social fears, and their association with comorbidity, health-related quality of life and help seeking" (PDF). Social Psychiatry and Psychiatric Epidemiology. 43 (4): 273–9. doi:10.1007/s00127-008-0309-1. PMID 18219433. S2CID 8450876. Archived (PDF) from the original on 2021-02-25. Retrieved 2021-01-03.
  14. 1 2 3 "Comorbidity". The Wiley Blackwell Handbook of Social Anxiety Disorder. 2014. pp. 208–210. doi:10.1002/9781118653920.fmatter. ISBN 9781118653920.
  15. 1 2 Beesdo, K.; Bittner, A.; Pine, D. S.; Stein, M. B.; Höfler, M.; Lieb, R.; Wittchen, H. U. (2007). "Incidence of Social Anxiety Disorder and the Consistent Risk for Secondary Depression in the First Three Decades of Life". Archives of General Psychiatry. 64 (8): 903–912. doi:10.1001/archpsyc.64.8.903. PMID 17679635.
  16. 1 2 Stein, M. B.; Fuetsch, M.; Müller, N.; Höfler, M.; Lieb, R.; Wittchen, H. U. (2001). "Social Anxiety Disorder and the Risk of Depression: A Prospective Community Study of Adolescents and Young Adults". Archives of General Psychiatry. 58 (3): 251–256. doi:10.1001/archpsyc.58.3.251. PMID 11231832.
  17. ↑ Heeren A, Jones PJ, McNally RJ (2018). "Mapping network connectivity among symptoms of social anxiety and comorbid depression in people with social anxiety disorder". Journal of Affective Disorders. 228: 75–82. doi:10.1016/j.jad.2017.12.003. PMID 29232567. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  18. ↑ Chartier, M. J.; Walker, J. R.; Stein, M. B. (2003). "Considering comorbidity in social phobia". Social Psychiatry and Psychiatric Epidemiology. 38 (12): 728–34. doi:10.1007/s00127-003-0720-6. PMID 14689178. S2CID 43116158.
  19. ↑ Sanderson, W. C.; Dinardo, P. A.; Rapee, R. M.; Barlow, D. H. (1990). "Syndrome comorbidity in patients diagnosed with a DSM-III--R anxiety disorder". Journal of Abnormal Psychology. 99 (3): 308–12. doi:10.1037/0021-843X.99.3.308. PMID 2212281.
  20. ↑ Chambless, D. L.; Fydrich, T.; Rodebaugh, T. L. (2008). "Generalized social phobia and avoidant personality disorder: Meaningful distinction or useless duplication?". Depression and Anxiety. 25 (1): 8–19. doi:10.1002/da.20266. PMID 17161000. S2CID 493410.
  21. ↑ Schneier, F. R.; Spitzer, R. L.; Gibbon, M.; Fyer, A. J.; Liebowitz, M. R. (1991). "The relationship of social phobia subtypes and avoidant personality disorder". Comprehensive Psychiatry. 32 (6): 496–502. doi:10.1016/0010-440X(91)90028-B. PMID 1778076.
  22. ↑ Buckner, J. D.; Schmidt, N. B.; Lang, A. R.; Small, J. W.; Schlauch, R. C.; Lewinsohn, P. M. (2008). "Specificity of social anxiety disorder as a risk factor for alcohol and cannabis dependence". Journal of Psychiatric Research. 42 (3): 230–9. doi:10.1016/j.jpsychires.2007.01.002. PMC 2254175. PMID 17320907.
  23. ↑ Morris, E. P.; Stewart, S. H.; Ham, L. S. (2005). "The relationship between social anxiety disorder and alcohol use disorders: A critical review". Clinical Psychology Review. 25 (6): 734–60. doi:10.1016/j.cpr.2005.05.004. PMID 16042994.
  24. ↑ Alfano, Candice A.; Beidel, Deborah C. (2011). "Alcohol and Drug Use in Socially Anxious Young Adults". Social anxiety in adolescents and young adults: Translating developmental science into practice. pp. 108–111. doi:10.1037/12315-000. ISBN 978-1-4338-0948-4.
  25. ↑ Kushner, M. G.; Abrams, K.; Thuras, P.; Hanson, K. L.; Brekke, M.; Sletten, S. (2005). "Follow-up Study of Anxiety Disorder and Alcohol Dependence in Comorbid Alcoholism Treatment Patients". Alcoholism: Clinical & Experimental Research. 29 (8): 1432–1443. doi:10.1097/01.alc.0000175072.17623.f8. PMID 16131851. S2CID 26834258. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  26. ↑ "Social anxiety disorder." CareNotes. Truven Health Analytics Inc., 2012. Health Reference Center Academic. Web. 15 Nov. 2012.
  27. ↑ Erliksson, Olivia J. (26 July 2020). "Measuring associations between social anxiety and use of different types of social media using the Swedish Social Anxiety Scale for Social Media Users: A psychometric evaluation and cross-sectional study". Scandinavian Journal of Psychology. 61 (6): 819–826. doi:10.1111/sjop.12673. PMID 32713014. Archived from the original on 3 May 2021. Retrieved 3 January 2021.
  28. ↑ Kendler K, Karkowski L, Prescott C (1999). "Fears and phobias: reliability and heritability". Psychol Med. 29 (3): 539–53. doi:10.1017/S0033291799008429. PMID 10405076.
  29. ↑ Merikangas, Avenevoli S., Dierker L., Grillon C. (1999). "Vulnerability factors among children at risk for anxiety disorders". Biol Psychiatry. 46 (11): 1523–1535. doi:10.1016/S0006-3223(99)00172-9. PMID 10599480. S2CID 24355342.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  30. ↑ Rapee, R. M. (2011). "Family Factors in the Development and Management of Anxiety Disorders". Clinical Child and Family Psychology Review. 15 (1): 69–80. doi:10.1007/s10567-011-0106-3. PMID 22116624. S2CID 20797633.
  31. ↑ Warren S, Huston L, Egeland B, Sroufe L (1997). "Child and adolescent anxiety disorders and early attachment". J Am Acad Child Adolesc Psychiatry. 36 (5): 637–644. doi:10.1097/00004583-199705000-00014. PMID 9136498. S2CID 22927346. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  32. ↑ Schwartz C, Snidman N, Kagan J (1999). "Adolescent social anxiety as an outcome of inhibited temperament in childhood". J Am Acad Child Adolesc Psychiatry. 38 (8): 1008–1015. doi:10.1097/00004583-199908000-00017. PMID 10434493. S2CID 23213088. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  33. ↑ National Center for Health and Wellness.Causes of Social Anxiety Disorder Archived 2005-12-01 at the Wayback Machine. Retrieved February 24, 2006.
  34. ↑ Athealth.com.Social phobia Archived 2014-03-22 at the Wayback Machine. 1999. Retrieved February 24, 2006.
  35. ↑ Mineka S, Zinbarg R (1995) Conditioning and ethological models of social phobia. In: Heimberg R, Liebowitz M, Hope D, Schneier F, editors. Social Phobia: Diagnosis, Assessment, and Treatment. New York: The Guilford Press, 134–162
  36. ↑ Beidel, D.C., & Turner, S.M. (1998). Shy children, phobic adults: The nature and treatment of social phobia. American Psychological Association Books.
  37. ↑ Ishiyama F (1984). "Shyness: Anxious social sensitivity and self-isolating tendency". Adolescence. 19 (76): 903–911. PMID 6516936.
  38. ↑ La Greca A, Dandes S, Wick P, Shaw K, Stone W (1988). "Development of the social anxiety scale for children: Reliability and concurrent validity". Journal of Clinical Child Psychology. 17: 84–91. doi:10.1207/s15374424jccp1701_11.
  39. ↑ Spence SH, Donovan C, Brechman-Toussaint M (May 1999). "Social skills, social outcomes, and cognitive features of childhood social phobia". J Abnorm Psychol. 108 (2): 211–21. doi:10.1037/0021-843X.108.2.211. PMID 10369031. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  40. ↑ Rubin KH, Mills RS (December 1988). "The many faces of social isolation in childhood". J Consult Clin Psychol. 56 (6): 916–24. doi:10.1037/0022-006X.56.6.916. PMID 3204203. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  41. ↑ Okano K (1994). "Shame and social phobia: a transcultural viewpoint". Bull Menninger Clin. 58 (3): 323–38. PMID 7920372.
  42. ↑ Xinyin C, Rubin KH, Boshu L (1995). "Social and school adjustment of shy and aggressive children in China". Development and Psychopathology. 7 (2): 337–349. doi:10.1017/s0954579400006544.
  43. ↑ Rapee RM, Lim L (November 1992). "Discrepancy between self- and observer ratings of performance in social phobics". J Abnorm Psychol. 101 (4): 728–31. doi:10.1037/0021-843X.101.4.728. PMID 1430614. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  44. ↑ Stopa L, Clark D (1993). "Cognitive processes in social phobia". Behav Res Ther. 31 (3): 255–67. doi:10.1016/0005-7967(93)90024-O. PMID 8476400.
  45. ↑ Segrin, Chris; Kinney, Terry (1995). "Social skills deficits among the socially anxious: Rejection from others and loneliness". Motivation and Emotion. 19 (1): 1–24. doi:10.1007/BF02260670. S2CID 144897963.
  46. ↑ Heimberg, R.G; Stein, M.B; Hiripi, E; Kessler, R.C (2000). "Trends in the prevalence of social phobia in the United States: A synthetic cohort analysis of changes over four decades". European Psychiatry. 15 (1): 29–37. doi:10.1016/S0924-9338(00)00213-3. PMID 10713800.
  47. ↑ Baumeister R, Leary M (1995). "The need to belong: desire for interpersonal attachments as a fundamental human motivation". Psychol Bull. 117 (3): 497–529. doi:10.1037/0033-2909.117.3.497. PMID 7777651. S2CID 13559932. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  48. ↑ Terra MB, Figueira I, Barros HM (August 2004). "Impact of alcohol intoxication and withdrawal syndrome on social phobia and panic disorder in alcoholic inpatients". Rev Hosp Clin Fac Med Sao Paulo. 59 (4): 187–92. doi:10.1590/S0041-87812004000400006. PMID 15361983.
  49. ↑ BNF; British Medical Journal (2008). "Anxiolytics". UK: British National Formulary. Archived from the original on 29 August 2021. Retrieved 17 December 2008.
  50. ↑ Allgulander C, Bandelow B, Hollander E, et al. (August 2003). "WCA recommendations for the long-term treatment of generalized anxiety disorder". CNS Spectr. 8 (8 Suppl 1): 53–61. doi:10.1017/S1092852900006945. PMID 14767398.
  51. ↑ Stevens JC, Pollack MH (2005). "Benzodiazepines in clinical practice: consideration of their long-term use and alternative agents". J Clin Psychiatry. 66 Suppl 2: 21–7. PMID 15762816. Archived from the original on 2013-04-19. Retrieved 2021-01-03.
  52. ↑ Bruce SE, Vasile RG, Goisman RM, Salzman C, Spencer M, Machan JT, Keller MB (August 2003). "Are benzodiazepines still the medication of choice for patients with panic disorder with or without agoraphobia?". Am J Psychiatry. 160 (8): 1432–8. doi:10.1176/appi.ajp.160.8.1432. PMID 12900305.
  53. 1 2 Cohen SI (February 1995). "Alcohol and benzodiazepines generate anxiety, panic and phobias". J R Soc Med. 88 (2): 73–7. PMC 1295099. PMID 7769598.
  54. ↑ Beck AT, Emery G, Greenberg RL (1985) Anxiety Disorders and Phobias: A Cognitive Perspective. New York: Basic Books.
  55. 1 2 Heeren A, Bernstein EE, McNally RJ (2020). "Bridging maladaptive social self-beliefs and social anxiety: a network perspective". Journal of Anxiety Disorders. 74: 102267. doi:10.1016/j.janxdis.2020.102267. PMID 32599433. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  56. ↑ "What is the core fear in social phobia | Request PDF". ResearchGate. Archived from the original on 2021-08-29. Retrieved 2020-01-26.
  57. ↑ Leary, M.R., & Kowalski, R.M. (1995) Social Anxiety. London: Guildford Press
  58. ↑ Leary M.R.; Kowalski R.M; Campbell C.D. (1988). "Self-presentational concerns and social anxiety: the role of generalized impression expectancies". Journal of Research in Personality. 22 (3): 308–321. doi:10.1016/0092-6566(88)90032-3.
  59. ↑ Clark, D. M., & Wells, A. (1995). A cognitive model of social phobia. In. R. G. Heimberg, M. R. Liebowitz, D. A. Hope, & F. R. Schneier (Eds.), Social phobia: Diagnosis, assessment, and treatment (pg 41–68). Guilford Press: New York.
  60. ↑ Rapee, Ronald M; Heimberg, Richard G (1997). "A cognitive-behavioral model of anxiety in social phobia". Behaviour Research and Therapy. 35 (8): 741–56. doi:10.1016/S0005-7967(97)00022-3. PMID 9256517.
  61. 1 2 3 M. S. Marcin; C. B. Nemeroff (2003). "The neurobiology of social anxiety disorder:the relevance of fear and anxiety". Acta Psychiatr Scand. 108 (417): 51–64. doi:10.1034/j.1600-0447.108.s417.4.x. PMID 12950436. S2CID 23732609.
  62. ↑ Sanjay J. Mathew; Jeremy D. Coplan; Jack M. Gorman (2001). "Neurobiological Mechanisms of Social Anxiety Disorder". Am J Psychiatry. 158 (10): 1558–1567. doi:10.1176/appi.ajp.158.10.1558. PMID 11578981. S2CID 11073595. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  63. ↑ Rammsayer T. H. (1998). "Extraversion and dopamine: Individual differences in response to changes in dopaminergic activity as a possible biological basis of extraversion". European Psychologist. 3 (1): 37–50. doi:10.1027/1016-9040.3.1.37.
  64. ↑ Diana Martinez; Daria Orlowska; Rajesh Narendran; Mark Slifstein; Fei Liu; Dileep Kumar; Allegra Broft; Ronald Van Heertum & Herbert D. Kleber (2010). "D2/3 receptor availability in the striatum and social status in human volunteers". Biol Psychiatry. 67 (3): 275–278. doi:10.1016/j.biopsych.2009.07.037. PMC 2812584. PMID 19811777.
  65. ↑ Franklin R. Schneier, M.D., Michael R. Liebowitz, M.D., Anissa Abi-Dargham, M.D., Yolanda Zea-Ponce, Shu-Hsing Lin, and Marc Laruelle, M.D. (2000). "Low Dopamine D2 Receptor Binding Potential in Social Phobia". Am J Psychiatry. 157 (3): 457–459. doi:10.1176/appi.ajp.157.3.457. PMID 10698826.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  66. 1 2 van der Wee; et al. (May 2008). "Increased Serotonin and Dopamine Transporter Binding in Psychotropic Medication–Naïve Patients with Generalized Social Anxiety Disorder Shown by 123I-ß-(4-Iodophenyl)-Tropane SPECT". The Journal of Nuclear Medicine. 49 (5): 757–63. doi:10.2967/jnumed.107.045518. PMID 18413401.
  67. ↑ Jari Tiihonen, M.D., Jyrki Kuikka, Kim Bergström, Ulla Lepola, M.D., Hannu Koponen, M.D., and Esa Leinonen, M.D. (1997). "Dopamine Reuptake Site Densities in Patients With Social Phobia". Am J Psychiatry. 154 (2): 239–242. doi:10.1176/ajp.154.2.239. PMID 9016274.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  68. ↑ Franklin R. Schneier, M.D., Anissa Abi-Dargham, M.D., Diana Martinez, M.D., Mark Slifstein, Dah-Ren Hwang, Michael R. Liebowitz, M.D., and Marc Laruelle, M.D. (2009). "Dopamine Transporters, D2 Receptors, and Dopamine Release in Generalized Social Anxiety Disorder". Depression and Anxiety. 26 (5): 411–418. doi:10.1002/da.20543. PMC 2679094. PMID 19180583.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  69. ↑ Kummer A, Cardoso F, Teixeira AL (2008). "Frequency of social phobia and psychometric properties of the Liebowitz social anxiety scale in Parkinson's disease". Mov. Disord. 23 (12): 1739–1743. doi:10.1002/mds.22221. PMID 18661550. S2CID 23392542.
  70. ↑ Mikkelsen EJ, Detlor J, Cohen DJ (1981). "School avoidance and social phobia triggered by haloperidol in patients with Tourette's disorder". Am J Psychiatry. 138 (12): 1572–1576. doi:10.1176/ajp.138.12.1572. PMID 6946714.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  71. ↑ Lanzenberger, R. R.; Mitterhauser, M.; Spindelegger, C.; Wadsak, W.; Klein, N.; Mien, L. K.; Holik, A.; Attarbaschi, T.; Mossaheb, N.; Sacher, J.; Geiss-Granadia, T.; Kletter, K.; Kasper, S.; Tauscher, J. (2007). "Reduced Serotonin-1A Receptor Binding in Social Anxiety Disorder". Biological Psychiatry. 61 (9): 1081–1089. doi:10.1016/j.biopsych.2006.05.022. PMID 16979141. S2CID 2076639. Archived from the original on 2021-01-28. Retrieved 2021-01-03.
  72. ↑ Pollack, M. H.; Jensen, J. E.; Simon, N. M.; Kaufman, R. E.; Renshaw, P. F. (2008). "High-field MRS study of GABA, glutamate and glutamine in social anxiety disorder: Response to treatment with levetiracetam". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32 (3): 739–743. doi:10.1016/j.pnpbp.2007.11.023. PMID 18206286. S2CID 1066103.
  73. ↑ Davidson, Richard J; Marshall, John R; Tomarken, Andrew J; Henriques, Jeffrey B (2000). "While a phobic waits: Regional brain electrical and autonomic activity in social phobics during anticipation of public speaking". Biological Psychiatry. 47 (2): 85–95. doi:10.1016/S0006-3223(99)00222-X. PMID 10664824. S2CID 20886832.
  74. ↑ Eisenberger NI, Lieberman MD, Williams KD (October 2003). "Does rejection hurt? An FMRI study of social exclusion". Science. 302 (5643): 290–2. Bibcode:2003Sci...302..290E. doi:10.1126/science.1089134. PMID 14551436. S2CID 21253445. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  75. ↑ Heeren A, Dricot L, Billieux J, Philippot P, Grynberg D, de Timary P, Maurage, P (2017). "Correlates of Social Exclusion in Social Anxiety Disorder: An fMRI study". Scientific Reports. 7 (1): 260. Bibcode:2017NatSR...7..260H. doi:10.1038/s41598-017-00310-9. PMC 5428215. PMID 28325901. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  76. ↑ Heeren A, Billieux J, Philippot P, De Raedt R, Baeken C, de Timary P, Maurage P, Vanderhasselt MA (2017). "Impact of transcranial direct current stimulation on attentional bias for threat: a proof-of-concept study among individuals with social anxiety disorder". Social Cognitive and Affective Neuroscience. 12 (2): 251–260. doi:10.1093/scan/nsw119. PMC 5390730. PMID 27531388. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  77. ↑ Etkin, Amit; Wager, Tor D. (2007-10-01). "Functional Neuroimaging of Anxiety: A Meta-Analysis of Emotional Processing in PTSD, Social Anxiety Disorder, and Specific Phobia". The American Journal of Psychiatry. 164 (10): 1476–1488. doi:10.1176/appi.ajp.2007.07030504. ISSN 0002-953X. PMC 3318959. PMID 17898336.
  78. ↑ Social Phobia (F40.1) in ICD-10: Diagnostic Criteria Archived 2016-06-18 at the Wayback Machine and Clinical descriptions and guidelines. Archived 2014-03-23 at the Wayback Machine
  79. ↑ Connor K.M.; Jonathan R.T.; et al. (2000). "Psychometric properties of the Social Phobia Inventory (SPIN): New self-rating scale". The British Journal of Psychiatry. 176 (4): 379–386. doi:10.1192/bjp.176.4.379. PMID 10827888.
  80. ↑ Anthony MM.; Coons MJ.; et al. (Aug 2006). "Psychometric properties of the social phobia inventory: further evaluation". Behav. Res. Ther. 44 (8): 1177–85. doi:10.1016/j.brat.2005.08.013. PMID 16257387.
  81. ↑ Liebowitz MR (1987). "Social Phobia". Anxiety. Mod Probl Pharmacopsychiatry. Modern Trends in Pharmacopsychiatry. Vol. 22. pp. 141–173. doi:10.1159/000414022. ISBN 978-3-8055-4488-7. PMID 2885745.
  82. ↑ García-López, L. J; Hidalgo, M. D.; Beidel, D. C.; Olivares, J.; Turner, S. M. (2008). "Brief form of the Social Phobia and Anxiety Inventory (SPAI-B) for adolescents". European Journal of Psychological Assessment. 24 (3): 150–156. doi:10.1027/1015-5759.24.3.150. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  83. ↑ Mattick, R. P.; Clarke, J. C. (1998-04-01). "Development and validation of measures of social phobia scrutiny fear and social interaction anxiety". Behaviour Research and Therapy. 36 (4): 455–470. doi:10.1016/s0005-7967(97)10031-6. ISSN 0005-7967. PMID 9670605.
  84. ↑ Diagnostic and statistical manual of mental disorders (DSM-5). Arlington: American Psychiatric Publishing. 2013. p. 202. ISBN 978-0-89042-555-8.
  85. ↑ Gagan Joshi • Carter Petty • Janet Wozniak • Aude Henin • Ronna Fried • Maribel Galdo • Meghan Kotarski • Sarah Walls • Joseph Biederman (2010). "The Heavy Burden of Psychiatric Comorbidity in Youth with Autism Spectrum Disorders: A Large Comparative Study of a Psychiatrically Referred Population". J Autism Dev Disord. 40 (11): 1361–1370. doi:10.1007/s10803-010-0996-9. PMID 20309621. S2CID 27441566.
  86. ↑ Pini S, Maser JD, Dell'Osso L, et al. (2006). "Social anxiety disorder comorbidity in patients with bipolar disorder: a clinical replication". J Anxiety Disord. 20 (8): 1148–57. doi:10.1016/j.janxdis.2006.03.006. PMID 16630705.
  87. ↑ Perugi G, Akiskal HS (December 2002). "The soft bipolar spectrum redefined: focus on the cyclothymic, anxious-sensitive, impulse-dyscontrol, and binge-eating connection in bipolar II and related conditions". Psychiatr. Clin. North Am. 25 (4): 713–37. doi:10.1016/S0193-953X(02)00023-0. PMID 12462857.
  88. ↑ David, B (2006). "ADHD With Comorbid Anxiety: A Review of the Current Literature". Journal of Attention Disorders. 10 (2): 141–149. doi:10.1177/1087054706286698. PMID 17085624. S2CID 22999439.
  89. ↑ Bienvenu, O. Joseph; Ginsburg, Golda S. (1 January 2007). "Prevention of anxiety disorders". International Review of Psychiatry. 19 (6): 647–654. doi:10.1080/09540260701797837. PMID 18092242. S2CID 95140.
  90. ↑ Lau, Elizabeth X.; Rapee, Ronald M. (12 April 2011). "Prevention of Anxiety Disorders". Current Psychiatry Reports. 13 (4): 258–266. doi:10.1007/s11920-011-0199-x. PMID 21484451. S2CID 34057141.
  91. ↑ Drake, Kelly L.; Ginsburg, Golda S. (13 January 2012). "Family Factors in the Development, Treatment, and Prevention of Childhood Anxiety Disorders". Clinical Child and Family Psychology Review. 15 (2): 144–162. doi:10.1007/s10567-011-0109-0. PMID 22241071. S2CID 33706230.
  92. 1 2 3 National Institute for Health and Clinical Excellence: Guidance. Social Anxiety Disorder: Recognition, Assessment and Treatment Archived 2021-08-29 at the Wayback Machine. Leicester (UK): British Psychological Society; 2013. PMID 25577940
  93. ↑ Andersson, G.; Carlbring, P.; Holmström, A.; Sparthan, E.; Furmark, T.; Nilsson-Ihrfelt, E.; Buhrman, M.; Ekselius, L. (2006). "Internet-based self-help with therapist feedback and in vivo group exposure for social phobia: A randomized controlled trial". Journal of Consulting and Clinical Psychology. 74 (4): 677–686. doi:10.1037/0022-006X.74.4.677. PMID 16881775.
  94. ↑ Lewis, C; Pearce, J; Bisson, JI (January 2012). "Efficacy, cost-effectiveness and acceptability of self-help interventions for anxiety disorders: systematic review". The British Journal of Psychiatry. 200 (1): 15–21. doi:10.1192/bjp.bp.110.084756. PMID 22215865. Archived from the original on 2013-10-14. Retrieved 2021-01-03.
  95. ↑ Kashdan, T. B.; Rottenberg, J. (2010). "Psychological flexibility as a fundamental aspect of health". Clinical Psychology Review. 30 (7): 865–878. doi:10.1016/j.cpr.2010.03.001. PMC 2998793. PMID 21151705.
  96. ↑ Bluett, EJ; et al. (Aug 2014). "Acceptance and commitment therapy for anxiety and OCD spectrum disorders: an empirical review". J Anxiety Disord. 28 (6): 612–24. doi:10.1016/j.janxdis.2014.06.008. PMID 25041735.
  97. ↑ Beidel, D. C.; Turner, S. M.; Sallee, F. R.; Ammerman, R. T.; Crosby, L. A.; Pathak, S. (2007). "SET-C Versus Fluoxetine in the Treatment of Childhood Social Phobia". Journal of the American Academy of Child & Adolescent Psychiatry. 46 (12): 1622–1632. doi:10.1097/chi.0b013e318154bb57. PMID 18030084.
  98. ↑ Bögels, S. M.; Voncken, M. (2008). "Social Skills Training Versus Cognitive Therapy for Social Anxiety Disorder Characterized by Fear of Blushing, Trembling, or Sweating". International Journal of Cognitive Therapy. 1 (2): 138–150. doi:10.1521/ijct.2008.1.2.138.
  99. ↑ Beidel, D. C.; Turner, S. M. (2007). Shy children, phobic adults: Nature and treatment of social anxiety disorders (2nd ed.). doi:10.1037/11533-000. ISBN 978-1-59147-452-4. S2CID 142348624. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  100. ↑ Stravynski & Amado, 2001
  101. ↑ Weiller, E.; Bisserbe, J. C.; Boyer, P.; Lepine, J. P.; Lecrubier, Y. (1996). "Social phobia in general health care: An unrecognised undertreated disabling disorder". The British Journal of Psychiatry. 168 (2): 169–174. doi:10.1192/bjp.168.2.169. PMID 8837906.
  102. ↑ Rosenthal, J.; Jacobs, L.; Marcus, M.; Katzman, M. A. (2007). "Beyond shy: When to suspect social anxiety disorder". The Journal of Family Practice. 56 (5): 369–374. PMID 17475167.
  103. ↑ Katzelnick, D. J.; Greist, J. H. (2001). "Social anxiety disorder: An unrecognized problem in primary care". The Journal of Clinical Psychiatry. 62 Suppl 1: 11–15, discussion 15–6. PMID 11206029.
  104. ↑ Stuart Montgomery; Hans Den Boer, eds. (2001). SSRIs in Depression and Anxiety. John Wiley and Sons. pp. 109–111. ISBN 978-0-470-84136-5.
  105. ↑ Liebowitz, Michael R.; Schneier, Franklin R.; Bragdon, Laura B.; Blanco, Carlos (2013-02-01). "The evidence-based pharmacotherapy of social anxiety disorder". International Journal of Neuropsychopharmacology. 16 (1): 235–249. doi:10.1017/S1461145712000119. ISSN 1461-1457. PMID 22436306.
  106. ↑ Publishing, Harvard Health. "Treating social anxiety disorder". Harvard Health. Archived from the original on 2020-09-23. Retrieved 2019-03-03.
  107. ↑ Kramer, Peter D.; Kramer, Peter D. "Antidepressants don't just treat depression–they can make us more sociable, too". Quartz. Archived from the original on 2019-03-06. Retrieved 2019-03-03.
  108. ↑ Hendrick, Bill. "Antidepressant Paxil Also May Affect Personality Traits". WebMD. Archived from the original on 2019-03-06. Retrieved 2019-03-03.
  109. ↑ Stein MB, Liebowitz MR, Lydiard RB, Pitts CD, Bushnell W, Gergel I (August 1998). "Paroxetine treatment of generalized social phobia (social anxiety disorder): a randomized controlled trial". JAMA. 280 (8): 708–13. doi:10.1001/jama.280.8.708. PMID 9728642.
  110. ↑ Davidson JR, Foa EB, Huppert JD, et al. (October 2004). "Fluoxetine, comprehensive cognitive behavioral therapy, and placebo in generalized social phobia". Arch. Gen. Psychiatry. 61 (10): 1005–13. doi:10.1001/archpsyc.61.10.1005. PMID 15466674.
  111. ↑ Blanco, Carlos; Bragdon, Laura B.; Schneier, Franklin R.; Liebowitz, Michael R. (2012-03-21). "The evidence-based pharmacotherapy of social anxiety disorder". The International Journal of Neuropsychopharmacology. 16 (1): 235–249. doi:10.1017/s1461145712000119. ISSN 1461-1457. PMID 22436306.
  112. ↑ Varia, Indu M.; Cloutier, Charles A.; Doraiswamy, P. Murali (January 2002). "Treatment of social anxiety disorder with citalopram". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 26 (1): 205–208. doi:10.1016/s0278-5846(01)00236-6. ISSN 0278-5846. PMID 11853114. S2CID 39547725.
  113. ↑ Social Phobia at eMedicine
  114. ↑ Federal Drug and Administration. Class Suicidality Labeling Language for Antidepressants Archived 2007-09-29 at the Wayback Machine. 2004. Retrieved February 24, 2006.
  115. ↑ Group Health Cooperative. Study refutes link between suicide risk, antidepressants Archived 2016-07-22 at the Wayback Machine January 1, 2006. Retrieved February 24, 2006.
  116. ↑ "Bipolars and social phobia". Biopsychiatry.com. Archived from the original on 2010-04-02. Retrieved 2010-04-14.
  117. ↑ Valença AM, Nardi AE, Nascimento I, et al. (May 2005). "Do social anxiety disorder patients belong to a bipolar spectrum subgroup?". J Affect Disord. 86 (1): 11–8. doi:10.1016/j.jad.2004.12.007. PMID 15820266.
  118. ↑ Blanco, C.; Bragdon, L. B.; Schneier, F. R.; Liebowitz, M. R. (2012). "The evidence-based pharmacotherapy of social anxiety disorder". The International Journal of Neuropsychopharmacology. 16 (1): 235–249. doi:10.1017/S1461145712000119. PMID 22436306.
  119. ↑ Menkes, D.; Bosanac, P.; Castle, D. (August 2016). "MAOIs - does the evidence warrant their resurrection?". Australas Psychiatry. 24 (4): 371–3. doi:10.1177/1039856216634824. PMID 26917855. S2CID 46826223.
  120. ↑ Davidson JR (2006). "Pharmacotherapy of social anxiety disorder: what does the evidence tell us?". J Clin Psychiatry. 67 Suppl 12: 20–6. doi:10.1016/j.genhosppsych.2005.07.002. PMID 17092192.
  121. ↑ Westenberg, HG. (Jul 1999). "Facing the challenge of social anxiety disorder". Eur Neuropsychopharmacol. 9 Suppl 3: S93–9. doi:10.1016/S0924-977X(99)00029-2. PMID 10523064. S2CID 26599290.
  122. ↑ Aouizerate, B.; Martin-Guehl, C.; Tignol, J. (2004). "[Neurobiology and pharmacotherapy of social phobia]". Encephale. 30 (4): 301–13. doi:10.1016/S0013-7006(04)95442-5. PMID 15538306.
  123. ↑ Mula M, Pini S, Cassano GB (June 2007). "The role of anticonvulsant drugs in anxiety disorders: a critical review of the evidence". J Clin Psychopharmacol. 27 (3): 263–72. doi:10.1097/jcp.0b013e318059361a. PMID 17502773. S2CID 38188832.
  124. ↑ Alan F. Schatzberg; Jonathan O. Cole; Charles DeBattista (2010). Manual of Clinical Psychopharmacology. American Psychiatric Pub. pp. 344–345. ISBN 978-1-58562-377-8. Archived from the original on 2016-04-25. Retrieved 2021-01-03.
  125. ↑ Liebowitz, M. R.; Gelenberg, A. J.; Munjack, D. (2005). "Venlafaxine Extended Release vs Placebo and Paroxetine in Social Anxiety Disorder". Archives of General Psychiatry. 62 (2): 190–198. doi:10.1001/archpsyc.62.2.190. PMID 15699296.
  126. ↑ Stein, M. B.; Pollack, M. H.; Bystritsky, A.; Kelsey, J. E.; Mangano, R. M. (2004). "Efficacy of low and higher dose extended-release venlafaxine in generalized social anxiety disorder: A 6-month randomized controlled trial". Psychopharmacology. 177 (3): 280–288. doi:10.1007/s00213-004-1957-9. PMID 15258718. S2CID 24842052.
  127. ↑ Rickels, K.; Mangano, R.; Khan, A. (2004). "A double-blind, placebo-controlled study of a flexible dose of venlafaxine ER in adult outpatients with generalized social anxiety disorder". Journal of Clinical Psychopharmacology. 24 (5): 488–496. doi:10.1097/01.jcp.0000138764.31106.60. PMID 15349004. S2CID 43524511.
  128. 1 2 Mario Maj et al., Personality Disorders, WPA series, evidence and experience in psychiatry 8, Hoboken, New Jersey: Wiley, 2005, ISBN 978-0-470-09036-7, p. 282 Archived 2021-03-23 at the Wayback Machine
  129. ↑ Muehlbacher M, Nickel MK, Nickel C, et al. (2005). "Mirtazapine reduces social anxiety and improves quality of life in women with social phobia". J Clin Psychopharmacol. 25 (6): 580–583. doi:10.1097/01.jcp.0000186871.04984.8d. PMID 16282842. S2CID 25093002.
  130. ↑ Schutters, S. I.; Van Megen, H. J.; Van Veen, J. F.; Denys, D. A.; Westenberg, H. G. (2010). "Mirtazapine in generalized social anxiety disorder: A randomized, double-blind, placebo-controlled study". International Clinical Psychopharmacology. 25 (5): 302–304. doi:10.1097/YIC.0b013e32833a4d71. PMID 20715300. S2CID 11103740.
  131. ↑ Emmanuel NP, Brawman-Mintzer O, Morton WA, Book SW, Johnson MR, Lorberbaum JP, Ballenger JC, Lydiard RB (2000). "Bupropion-SR in treatment of social phobia". Depression and Anxiety. 12 (2): 111–3. doi:10.1002/1520-6394(2000)12:2<111::AID-DA9>3.0.CO;2-3. PMID 11091936.
  132. ↑ Hofmann SG, Meuret AE, Smits JA, et al. (March 2006). "Augmentation of exposure therapy with D-cycloserine for social anxiety disorder". Arch. Gen. Psychiatry. 63 (3): 298–304. doi:10.1001/archpsyc.63.3.298. PMID 16520435.
  133. ↑ Hofmann SG, Pollack MH, Otto MW (2006). "Augmentation Treatment of Psychotherapy for Anxiety Disorders with D-Cycloserine". CNS Drug Rev. 12 (3–4): 208–17. doi:10.1111/j.1527-3458.2006.00208.x. PMC 2151200. PMID 17227287.
  134. ↑ Pittler MH, Ernst E (2003). Pittler MH (ed.). "Kava extract for treating anxiety". Cochrane Database of Systematic Reviews (1): CD003383. doi:10.1002/14651858.CD003383. PMC 6999799. PMID 12535473.
  135. ↑ Lim ST, Dragull K, Tang CS, Bittenbender HC, Efird JT, Nerurkar PV (May 2007). "Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats". Toxicol. Sci. 97 (1): 214–21. doi:10.1093/toxsci/kfm035. PMID 17329236.
  136. ↑ Sorrentino L, Capasso A, Schmidt M (September 2006). "Safety of ethanolic kava extract: Results of a study of chronic toxicity in rats". Phytomedicine. 13 (8): 542–9. doi:10.1016/j.phymed.2006.01.006. PMID 16904878.
  137. ↑ "Adults and Mental Health" (PDF). Archived (PDF) from the original on 2010-05-27. Retrieved 2010-04-14.
  138. 1 2 3 "The mental health of young people looked after by local authorities in Scotland" (PDF). Archived (PDF) from the original on 2004-07-22. Retrieved 2010-04-14.
  139. ↑ Andrews, G.; Issakidis, C.; Slade, T.; Lampe, L. (2003-05-13). "Social phobia in the Australian National Survey of Mental Health and Well-Being (NSMHWB)". Psychological Medicine. 33 (4): 637–646. doi:10.1017/S0033291703007621. PMID 12785465.
  140. ↑ Rocha FL, Vorcaro CM, Uchoa E, Lima-Costa MF (September 2005). "Comparing the prevalence rates of social phobia in a community according to ICD-10 and DSM-III-R". Rev Bras Psiquiatr. 27 (3): 222–4. doi:10.1590/S1516-44462005000400011. PMID 16224610.
  141. ↑ Khyati Mehtalia1, G.K. Vankar MF (September 2004). "Social Anxiety in Adolescents". Indian J Psychiatry. 46 (3): 221–227. PMC 2951647. PMID 21224903.
  142. ↑ Mohammadi MR; Ghanizadeh A; Mohammadi M; Mesgarpour B. MF (2006). "Prevalence of social phobia and its comorbidity with psychiatric disorders in Iran". Depress Anxiety. 23 (7): 405–411. doi:10.1002/da.20129. PMID 16817174. S2CID 33235784.
  143. ↑ Iulian Iancua; Jennifer Levinc; Haggai Hermeshd; Pinhas Dannonb; Amir Porehc; Yoram Ben-Yehudaa; Zeev Kaplana; Sofi Maromd; Moshe Kotler MF (September 2006). "Social phobia symptoms: prevalence, sociodemographic correlates, and overlap with specific phobia symptoms". Comprehensive Psychiatry. 47 (5): 399–405. doi:10.1016/j.comppsych.2006.01.008. PMID 16905404.
  144. ↑ Bella TT; Omigbodun O. MF (Jun 2009). "Social phobia in Nigerian university students: prevalence, correlates and co-morbidity". Soc Psychiatry Psychiatr Epidemiol. 44 (6): 458–63. doi:10.1007/s00127-008-0457-3. PMID 18979054. S2CID 11246633.
  145. ↑ Tillfors M; Furmark T. MF (January 2007). "Social phobia in Swedish university students: prevalence, subgroups and avoidant behavior". Soc Psychiatry Psychiatr Epidemiol. 42 (1): 79–86. doi:10.1007/s00127-006-0143-2. PMID 17160591. S2CID 26870508.
  146. ↑ Izgiç F; Akyüz G; Doğan O; Kuğu N. MF (September 2004). "Social phobia among university students and its relation to self-esteem and body image". Can J Psychiatry. 49 (9): 630–634. doi:10.1177/070674370404900910. PMID 15503736.
  147. ↑ Rabe-Jabłońska J (2002). "Fobia społeczna. Rozpowszechnienie, kryteria rozpoznawania, podtypy, przebieg, współchorobowość, leczenie". Psychiatria W Praktyce Ogólnolekarskiej. (in polski). 2 (3): 161–166. Archived from the original on 2015-12-22.
  148. ↑ 蘭, 李. (2010). "男女學生四至十一年級之社交焦慮發展軌跡研究" [A study of the developmental trajectory of social anxiety among boys and girls from 4th grade to 11th grade]. 臺灣公共衛生雜誌 (in 中文). 29 (5): 465–76. Archived from the original on 2021-03-22. Retrieved 2021-01-03.
  149. ↑ Stein, Murray B; Stein, Dan J (2008). "Social anxiety disorder". The Lancet. 371 (9618): 1115–1125. doi:10.1016/s0140-6736(08)60488-2. ISSN 0140-6736. PMID 18374843. S2CID 29814976. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  150. ↑ Stein, MB; Stein, DJ (Mar 2008). "Social anxiety disorder". Lancet. 371 (9618): 1115–25. doi:10.1016/S0140-6736(08)60488-2. PMID 18374843. S2CID 29814976.
  151. ↑ Social Anxiety Disorder: A Common, Underrecognized Mental Disorder Archived 2015-09-24 at the Wayback Machine. American Family Physician. Nov 15, 1999.
  152. ↑ "Anxiety Disorders". National Institute of Mental Health. Archived from the original on 19 April 2015. Retrieved 16 April 2015.
  153. ↑ Surgeon General and Mental Health Archived 2021-08-29 at the Wayback Machine 1999. Retrieved February 22, 2006.
  154. ↑ Nelson E. C.; Grant J. D.; Bucholz K. K.; Glowinski A.; Madden P. A. F.; Reich W.; et al. (2000). "Social phobia in a population-based female adolescent twin sample: Co-morbidity and associated suicide-related symptoms". Psychological Medicine. 30 (4): 797–804. doi:10.1017/S0033291799002275. PMID 11037087.
  155. ↑ Rapee R. M.; Spence S. H. (2004). "The etiology of social phobia: empirical evidence and an initial model". Clin Psychol Rev. 24 (7): 737–767. doi:10.1016/j.cpr.2004.06.004. PMID 15501555.
  156. ↑ Xu, Y.; Schneier, F.; Heimberg, R. G.; Princisvalle, K.; Liebowitz, M. R.; Wang, S.; Blanco, C. (2012). "Gender differences in social anxiety disorder: Results from the national epidemiologic sample on alcohol and related conditions". Journal of Anxiety Disorders. 26 (1): 12–19. doi:10.1016/j.janxdis.2011.08.006. PMID 21903358.
  157. ↑ Nordenberg, Tamar. FDA Consumer. U.S. Food and Drug Administration.Social Phobia's Traumas and Treatments Archived 2009-04-29 at the Wayback Machine. November–December 1999. Retrieved February 23, 2006.
  158. ↑ National Statistics. The mental health of young people looked after by local authorities in Scotland Archived 2004-07-22 at the UK Government Web Archive. 2002–2003. Retrieved February 23, 2006.
  159. ↑ Nova Scotia Department of Health.Social Anxiety in Nova Scotia Archived 2006-03-25 at the Wayback Machine. June 2004. Retrieved February 23, 2006.
  160. ↑ Senate Select Committee on Mental Health.Mental Health Archived 2006-03-25 at the Wayback Machine. 2003. Retrieved February 23, 2006.
  161. ↑ Furmark, T; Tillfors, M; Everz, P.-O; Marteinsdottir, I; Gefvert, O; Fredrikson, M (1999). "Social phobia in the general population: Prevalence and sociodemographic profile". Social Psychiatry and Psychiatric Epidemiology. 34 (8): 416–24. doi:10.1007/s001270050163. PMID 10501711. S2CID 12591450.
  162. ↑ Burton, Robert (1881). The anatomy of melancholy. Chatto & Windus. p. 253. ISBN 978-84-206-6026-4. Archived from the original on 2021-08-29. Retrieved 2021-01-03.
  163. ↑ Haustgen, T. (2004). "À propos du centenaire de la psychasthénie (1903) Les troubles obsessionnels-compulsifs dans la psychiatrie française: revue historique". Annales Médico-Psychologiques. 162 (6): 427–440. doi:10.1016/j.amp.2003.09.012.
  164. ↑ Liebowitz, M. R.; Gorman, J. M.; Fyer, A. J.; Klein, D. F. (1985). "Social phobia. Review of a neglected anxiety disorder". Archives of General Psychiatry. 42 (7): 729–736. doi:10.1001/archpsyc.1985.01790300097013. PMID 2861796.
  165. 1 2 Wen-Shing Tseng, Handbook of Cultural Psychiatry, San Diego: Academic Press, 2001, ISBN 978-0-12-701632-0, p. 238-239 Archived 2021-03-22 at the Wayback Machine
  166. ↑ Isaac Meyer Marks, Fears, Phobias and Rituals: Panic, Anxiety, and Their Disorders, New York: Oxford University, 1987, ISBN 978-0-19-503927-6, p. 367 Archived 2021-03-22 at the Wayback Machine
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