Terizidone

Terizidone
Names
Other names4-[({4-[N-(3-oxo-1,2-oxazolidin-4-yl)carboximidoyl]phenyl}methylidene)amino]-1,2-oxazolidin-3-one
IUPAC name
  • 4,4'-{1,4-Phenylenebis[(E)methylylidene
    (E)azanylylidene]}bis(1,2-oxazolidin-3-one)
Clinical data
Main usesTuberculosis[1]
Side effectsSeizures, slurred speech, trouble sleeping, confusion, depression[1]
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Pregnancy
category
  • C
External links
AHFS/Drugs.comInternational Drug Names
Chemical and physical data
FormulaC14H14N4O4
Molar mass302.290 g·mol−1
3D model (JSmol)
SMILES
  • O=C3NOCC3/N=C/c2ccc(/C=N/C1C(=O)NOC1)cc2
InChI
  • InChI=1S/C14H14N4O4/c19-13-11(7-21-17-13)15-5-9-1-2-10(4-3-9)6-16-12-8-22-18-14(12)20/h1-6,11-12H,7-8H2,(H,17,19)(H,18,20)/b15-5+,16-6+ checkY
  • Key:ODKYYBOHSVLGNU-IAGONARPSA-N checkY

Terizidone (Trd) is an antibiotic used to treat tuberculosis.[1] Specifically it is used in multi-drug-resistant tuberculosis (MDR-TB) when other agents are not suitable.[1] It is used together with other tuberculosis medication and vitamin B6.[2] It is generally take by mouth for about 2 years.[2]

Side effects may include seizures, slurred speech, trouble sleeping, confusion, and depression.[1] Side effects are believed to be less than the similar medication cycloserine.[1] It should not be used in those with significant kidney problems.[2] It works by stoping bacterial growth after being broken down into cycloserine.[1][3]

The medication may be available from the Stop TB Partnership.[4] It is not available in the United States.[1] It is on the World Health Organization's List of Essential Medicines as an alternative to cycloserine.[5] As of 2015, 50 tablets of 250 mg costs about 80 USD.[4]

References

  1. 1 2 3 4 5 6 7 8 Ramanathan, Meenakshi R. (2019). "Chapter 28 - Drugs in tuberculosis and leprosy". Side Effects of Drugs Annual. Elsevire. pp. 321–338. Archived from the original on 8 May 2023. Retrieved 12 September 2023.
  2. 1 2 3 "TERIZIDON, 250 mg, capsules, hard" (PDF). Archived (PDF) from the original on 13 September 2023. Retrieved 12 September 2023.
  3. ↑ Abraham, Donald J. (2021). Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set. John Wiley & Sons. ISBN 9781119530305. Archived from the original on 2023-09-13. Retrieved 2023-09-12.
  4. 1 2 The Selection and Use of Essential Medicines: Report of the WHO Expert Committee, 2015. WHO. 2015. p. 34. ISBN 9789241209946. Archived from the original on 13 September 2023. Retrieved 12 September 2023.
  5. ↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
Identifiers:
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