Thecoma

Thecoma
High magnification micrograph of a thecoma. H&E stain.
SpecialtyGynaecology
FrequencyUncommon[1]

Thecoma is a noncancerous ovarian tumor.[1]

It is composed cells resembling theca cells.[1] It is a type of sex cord-stromal tumour.[1]

They are typically estrogen-producing and they occur in older women (mean age 59; 84% after menopause). (They can, however, appear before menopause.[2])

60% of cases present with abnormal uterine bleeding, and 20% have endometrial carcinoma.

Pathologic features

Low magnification micrograph of a thecoma showing compression of the ovarian cortex (right of image). H&E stain.

Grossly, the tumour is solid and yellow.

Grossly and microscopically, it consists of the ovarian cortex.

Microscopically, the tumour cells have abundant lipid-filled cytoplasm.

References

  1. 1 2 3 4 WHO Classification of Tumours Editorial Board, ed. (2020). "1. Tumours of the ovary". Female genital tumours: WHO Classification of Tumours. Vol. 4 (5th ed.). Lyon (France): International Agency for Research on Cancer. p. 94. ISBN 978-92-832-4504-9. Archived from the original on 2022-06-17. Retrieved 2023-07-03.
  2. ↑ Okada I, Nakagawa S, Takemura Y, et al. (October 2004). "Ovarian thecoma associated in the first trimester of pregnancy". J. Obstet. Gynaecol. Res. 30 (5): 368–71. doi:10.1111/j.1447-0756.2004.00212.x. PMID 15327450. S2CID 28580115.
Classification
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