Type I cytokine receptor

Type I cytokine receptor, cytokine-binding domain
Identifiers
SymbolTypeI_recpt_CBD
PfamPF09240
Pfam clanCL0159
InterProIPR015321
SCOP21n26 / SCOPe / SUPFAM
Membranome2

Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.

The common cytokine-binding domain is related to the Fibronectin type III domain.

Signal transduction chains

The signal transducing chains are often shared between different receptors within this receptor family.[1]

  • The IL-2 receptor common gamma chain (also known as CD132) is shared between:
  • The common beta chain (CD131 or CDw131) is shared between the following type I cytokine receptors:
  • The gp130 receptor (Glycoprotein 130) (also known as gp130, IL6ST, IL6-beta or CD130) is shared between:
    • IL-6 receptor
    • IL-11 receptor
    • IL-12 receptor
    • IL-27 receptor
    • Leukemia inhibitory factor receptor
    • Oncostatin M receptor

Examples

Type I cytokine receptors include interleukin receptors, colony stimulating factor receptors and other cytokine receptors

Interleukin receptors

  • Interleukin-1 receptor
  • Interleukin-2 receptor
  • Interleukin-3 receptor
  • Interleukin-4 receptor
  • Interleukin-5 receptor
  • Interleukin-6 receptor
  • Interleukin-7 receptor
  • Interleukin-9 receptor
  • Interleukin-11 receptor
  • Interleukin-12 receptor
  • Interleukin-13 receptor
  • Interleukin-15 receptor
  • Interleukin-18 receptor
  • Interleukin-21 receptor
  • Interleukin-23 receptor
  • Interleukin-27 receptor

Colony stimulating factor receptors

  • Erythropoietin receptor
  • GM-CSF receptor
  • G-CSF receptor
  • Thrombopoietin receptor

Hormone receptor/neuropeptide receptor

  • Growth hormone receptor
  • Prolactin receptor
  • Leptin receptor[5]

Other

  • Oncostatin M receptor
  • Leukemia inhibitory factor receptor

References

  1. Lichtman, Andrew H.; Abbas, Abul K. (2003). Cellular and molecular immunology (5th ed.). Philadelphia: Saunders. ISBN 0-7216-0008-5.
  2. He YW, Adkins B, Furse RK, Malek TR (1995). "Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor". J. Immunol. 154 (4): 1596–605. PMID 7530740.
  3. Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster K, Sugamura K (2001). "Cutting edge: the common γ-chain is an indispensable subunit of the IL21 receptor complex". J. Immunol. 167 (1): 1–5. doi:10.4049/jimmunol.167.1.1. PMID 11418623.
  4. Stomski FC, Woodcock JM, Zacharakis B, Bagley CJ, Sun Q, Lopez AF (1998). "Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors". J. Biol. Chem. 273 (2): 1192–9. doi:10.1074/jbc.273.2.1192. PMID 9422786.
  5. Cirillo, Donatella; Rachiglio, Anna Maria; la Montagna, Raffaele; Giordano, Antonio; Normanno, Nicola (1 November 2008). "Leptin signaling in breast cancer: An overview". Journal of Cellular Biochemistry. 105 (4): 956–964. doi:10.1002/jcb.21911. PMID 18821585.
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