Vitamin E deficiency

Vitamin E deficiency
MRI progressive ataxia due to alpha-tocopherol deficiency

Vitamin E deficiency in humans is a very rare condition, occurring as a consequence of abnormalities in dietary fat absorption or metabolism rather than from a diet low in vitamin E.[1] Collectively the EARs, RDAs, AIs and ULs for vitamin E and other essential nutrients are referred to as Dietary Reference Intakes (DRIs).[1] Vitamin E deficiency can cause nerve problems due to poor conduction of electrical impulses along nerves due to changes in nerve membrane structure and function.

Signs and symptoms

Signs of vitamin E deficiency include the following:

Causes

Vitamin E deficiency is rare. There are no records of it from simple lack of vitamin E in a person's diet, but it can arise from physiological abnormalities.[1] It occurs in the people in the following situations:[2][5]

  • Premature, very low birth weight infants – birth weights less than 1500 grams (3.3 pounds).[6]
  • Rare disorders of fat metabolism – There is a rare genetic condition termed isolated vitamin E deficiency or 'ataxia with isolated with vitamin E deficiency', caused by mutations in the gene for the tocopherol transfer protein.[7] These individuals have an extremely poor capacity to absorb vitamin E and develop neurological complications that are reversed by high doses of vitamin E.
  • Fat malabsorption – Some dietary fat is needed for the absorption of vitamin E from the gastrointestinal tract. Anyone diagnosed with cystic fibrosis, individuals who have had part or all of their stomach removed or who have had a gastric bypass, and individuals with malabsorptive problems such as Crohn's disease, liver disease or exocrine pancreatic insufficiency may not absorb fat (people who cannot absorb fat often pass greasy stools or have chronic diarrhea and bloating). Abetalipoproteinemia is a rare inherited disorder of fat metabolism that results in poor absorption of dietary fat and vitamin E.[8] The vitamin E deficiency associated with this disease causes problems such as poor transmission of nerve impulses and muscle weakness.

Diagnosis

The U.S. Institute of Medicine defines deficiency as a serum concentration of less than 12 μmol/L. The symptoms can be enough for a diagnosis to be formed.[1]

Treatment

Treatment is oral vitamin E supplementation.[3]

See also

References

  1. 1 2 3 4 5 6 Institute of Medicine (2000). "Vitamin E". Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: The National Academies Press. pp. 186–283. Archived from the original on 2018-02-26. Retrieved 2022-02-04.
  2. 1 2 3 4 Brigelius-Flohé R, Traber MG (July 1999). "Vitamin E: function and metabolism". FASEB J. 13 (10): 1145–55. doi:10.1096/fasebj.13.10.1145. PMID 10385606. S2CID 7031925.
  3. 1 2 3 Office of Dietary Supplements. "Vitamin E Professional Fact Sheet". National Institutes of Health. Archived from the original on 5 August 2010. Retrieved 14 August 2010.
  4. 1 2 Kowdley KV, Mason JB, Meydani SN, Cornwall S, Grand RJ (June 1992). "Vitamin E deficiency and impaired cellular immunity related to intestinal fat malabsorption". Gastroenterology. 102 (6): 2139–42. doi:10.1016/0016-5085(92)90344-x. PMID 1587435.
  5. Traber MG, Sies H (1996). "Vitamin E in humans: demand and delivery". Annu. Rev. Nutr. 16: 321–47. doi:10.1146/annurev.nu.16.070196.001541. PMID 8839930.
  6. Brion LP, Bell EF, Raghuveer TS (2003). "Vitamin E supplementation for prevention of morbidity and mortality in preterm infants". Cochrane Database Syst Rev. 2010 (4): CD003665. doi:10.1002/14651858.CD003665. PMID 14583988.
  7. Manor D, Morley S (2007). "The alpha-tocopherol transfer protein". Vitam. Horm. Vitamins & Hormones. 76: 45–65. doi:10.1016/S0083-6729(07)76003-X. ISBN 9780123735928. PMID 17628171.
  8. Muller DP, Lloyd JK, Wolff OH (1983). "Vitamin E and neurological function: abetalipoproteinaemia and other disorders of fat absorption". Ciba Found. Symp. Novartis Foundation Symposia. 101: 106–21. doi:10.1002/9780470720820.ch8. ISBN 9780470720820. PMID 6557902.
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