ACTA2

ACTA2 (actin alpha 2) is an actin protein with several aliases including alpha-actin, alpha-actin-2, aortic smooth muscle or alpha smooth muscle actin (α-SMA, SMactin, alpha-SM-actin, ASMA). Actins are a family of globular multi-functional proteins that form microfilaments. ACTA2 is one of 6 different actin isoforms and is involved in the contractile apparatus of smooth muscle. ACTA2 (as with all the actins) is extremely highly conserved and found in nearly all mammals.

ACTA2
Identifiers
AliasesACTA2, AAT6, ACTSA, MYMY5, actin, alpha 2, smooth muscle, aorta, actin alpha 2, smooth muscle
External IDsOMIM: 102620 MGI: 87909 HomoloGene: 133938 GeneCards: ACTA2
Orthologs
SpeciesHumanMouse
Entrez

59

11475

Ensembl

ENSG00000107796

ENSMUSG00000035783

UniProt

P62736

P62737

RefSeq (mRNA)

NM_001141945
NM_001613
NM_001320855

NM_007392

RefSeq (protein)

NP_001135417
NP_001307784
NP_001604

NP_031418

Location (UCSC)Chr 10: 88.94 – 88.99 MbChr 19: 34.22 – 34.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

In humans, ACTA2 is encoded by the ACTA2 gene located on 10q22-q24.[5][6] Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, Moyamoya disease, and multisystemic smooth muscle dysfunction syndrome.[5]

ACTA2 (commonly referred to as alpha-smooth muscle actin or α-SMA) is often used as a marker of myofibroblast formation.[7] Studies have shown that ACTA2 is associated with TGF-β pathway that enhances contractile properties of hepatic stellate cells leading to liver fibrosis and cirrhosis.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000107796 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035783 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ACTA2 actin, alpha 2, smooth muscle, aorta".
  6. Ueyama H, Bruns G, Kanda N (June 1990). "Assignment of the vascular smooth muscle actin gene ACTSA to human chromosome 10". Jinrui Idengaku Zasshi. The Japanese Journal of Human Genetics. 35 (2): 145–50. doi:10.1007/BF01876459. PMID 2398629.
  7. Nagamoto T, Eguchi G, Beebe DC (April 2000). "Alpha-smooth muscle actin expression in cultured lens epithelial cells". Investigative Ophthalmology & Visual Science. 41 (5): 1122–9. PMID 10752950.
  8. Hassan, Sobia; Shah, Hussain; Shawana, Summayya (2020). "Dysregulated epidermal growth factor and tumor growth factor-beta receptor signaling through GFAP-ACTA2 protein interaction in liver fibrosis". Pakistan Journal of Medical Sciences. 36 (4): 782–787. doi:10.12669/pjms.36.4.1845. PMC 7260937. PMID 32494274.

Further reading


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