CEP250

Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene.[5][6][7] This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome.[7] Furthermore, CEP135 is also required for the centriolar localization of CEP250.[8]

CEP250
Identifiers
AliasesCEP250, C-NAP1, CEP2, CNAP1, centrosomal protein 250, CRDHL2
External IDsOMIM: 609689 MGI: 108084 HomoloGene: 38286 GeneCards: CEP250
Orthologs
SpeciesHumanMouse
Entrez

11190

16328

Ensembl

ENSG00000126001

ENSMUSG00000038241

UniProt

Q9BV73

Q60952

RefSeq (mRNA)

NM_001035518
NM_007186
NM_001318219

NM_001129999
NM_001130000
NM_008383
NM_177217

RefSeq (protein)

NP_001305148
NP_009117

NP_001123471
NP_001123472
NP_032409
NP_796191

Location (UCSC)Chr 20: 35.46 – 35.52 MbChr 2: 155.8 – 155.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000126001 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038241 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mack GJ, Rees J, Sandblom O, Balczon R, Fritzler MJ, Rattner JB (Apr 1998). "Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome". Arthritis Rheum. 41 (3): 551–8. doi:10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X. PMID 9506584.
  6. Fry AM, Mayor T, Meraldi P, Stierhof YD, Tanaka K, Nigg EA (Aug 1998). "C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2". J Cell Biol. 141 (7): 1563–74. doi:10.1083/jcb.141.7.1563. PMC 2133000. PMID 9647649.
  7. "Entrez Gene: CEP250 centrosomal protein 250kDa".
  8. Kim K, Lee S, Chang J, Rhee K (December 2008). "A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization". Exp. Cell Res. 314 (20): 3692–700. doi:10.1016/j.yexcr.2008.09.016. PMID 18851962.

Further reading


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